c-Myc directly targets an over-expression of pyruvate carboxylase in highly invasive breast cancer

Here we showed that the c-Myc oncogene is responsible for overexpression of pyruvate carboxylase (PC) in highly invasive MDA-MB-231 cells. Pharmacological inhibition of c-Myc activity with 10074-G5 compound, resulted in a marked reduction of PC mRNA and protein, concomitant with reduced cell growth,...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2020-03, Vol.1866 (3), p.165656-165656, Article 165656
Hauptverfasser:	Lao-On, Udom, Rojvirat, Pinnara, Chansongkrow, Pakkanan, Phannasil, Phatchariya, Siritutsoontorn, Siraprapa, Charoensawan, Varodom, Jitrapakdee, Sarawut
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaplerosis Breast cancer C-Myc Pyruvate carboxylase Transcription
Online-Zugang:	Volltext
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