MicroRNA-31/184 is involved in transforming growth factor-β-induced apoptosis in A549 human alveolar adenocarcinoma cells

TGF-β-induced alveolar epithelial cells apoptosis were involved in idiopathic pulmonary fibrosis (IPF). This study aimed to explore potential targets and mechanisms of IPF. mRNA and microRNA arrays were used to analyze differentially expressed genes and miRNAs. Several essential targets of TGF-β-SMA...

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Veröffentlicht in:	Life sciences (1973) 2020-02, Vol.242, p.117205-117205, Article 117205
Hauptverfasser:	Wang, Cong-Jie, Li, Bing-Bing, Tan, Yu-Jun, Zhang, Gui-Min, Cheng, Guo-Liang, Ren, Yu-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase A549 Cells - metabolism Adenocarcinoma AKT protein Alveolar epithelial cells Alveoli Apoptosis Apoptosis - drug effects Cbfa-1 protein Dimers Epithelial cells epithelium Fibrosis Fluorescent Antibody Technique gene expression regulation Growth factors Humans Idiopathic pulmonary fibrosis Idiopathic Pulmonary Fibrosis - metabolism Immunoprecipitation Lung diseases Matrilysin Micro RNA microRNA MicroRNAs MicroRNAs - metabolism MicroRNAs - physiology miRNA mRNA NF-kappa B - metabolism Oligonucleotide Array Sequence Analysis Phosphorylation Proto-Oncogene Proteins c-akt - metabolism pulmonary fibrosis Real-Time Polymerase Chain Reaction Ribonucleic acid RNA Signal Transduction Smad2 protein Smad2 Protein - metabolism Smad4 protein TGF-β signaling pathway Transforming Growth Factor beta - pharmacology Transforming growth factor-b Translocation Viability
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