Naringenin Enhances the Antitumor Effect of Therapeutic Vaccines by Promoting Antigen Cross-Presentation
Dendritic cells (DCs) can internalize and cross-present exogenous Ags to CD8 T cells for pathogen or tumor cell elimination. Recently, growing evidences suggest the possible immunoregulatory role of flavonoids through modulating the Ag presentation of DCs. In this study, we report that naringenin, a...
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| Veröffentlicht in: | The Journal of immunology (1950) 2020-02, Vol.204 (3), p.622-631 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 204 |
| creator | Wang, Luoyang Zeng, Wenfeng Wang, Luyao Wang, Zihao Yin, Xiaozhe Qin, Yan Zhang, Fayun Zhang, Chunling Liang, Wei |
| description | Dendritic cells (DCs) can internalize and cross-present exogenous Ags to CD8
T cells for pathogen or tumor cell elimination. Recently, growing evidences suggest the possible immunoregulatory role of flavonoids through modulating the Ag presentation of DCs. In this study, we report that naringenin, a grapefruit-derived flavonoid, possesses the ability to increase the Ag cross-presentation in both murine DC line DC2.4 as well as bone marrow-derived DCs, and naringenin-induced moderate intracellular oxidative stress that contributed to the disruption of lysosomal membrane enhanced Ag leakage to cytosol and cross-presentation. Moreover, in a murine colon adenocarcinoma model, naringenin induced more CD103
DCs infiltration into tumor and facilitated the activation of CD8
T cells and strengthened the performance of therapeutic E7 vaccine against TC-1 murine lung cancer. Our investigations may inspire novel thoughts for vaccine design and open a new field of potential applications of flavonoids as immunomodulators to improve host protection against infection and tumor. |
| doi_str_mv | 10.4049/jimmunol.1900278 |
| format | Article |
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T cells for pathogen or tumor cell elimination. Recently, growing evidences suggest the possible immunoregulatory role of flavonoids through modulating the Ag presentation of DCs. In this study, we report that naringenin, a grapefruit-derived flavonoid, possesses the ability to increase the Ag cross-presentation in both murine DC line DC2.4 as well as bone marrow-derived DCs, and naringenin-induced moderate intracellular oxidative stress that contributed to the disruption of lysosomal membrane enhanced Ag leakage to cytosol and cross-presentation. Moreover, in a murine colon adenocarcinoma model, naringenin induced more CD103
DCs infiltration into tumor and facilitated the activation of CD8
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DCs infiltration into tumor and facilitated the activation of CD8
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DCs infiltration into tumor and facilitated the activation of CD8
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| title | Naringenin Enhances the Antitumor Effect of Therapeutic Vaccines by Promoting Antigen Cross-Presentation |
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