Novel amide derivatives of 3-phenylglutaric acid as potent soluble epoxide hydrolase inhibitors

Soluble epoxide hydrolase (sEH) enzyme plays an important role in the metabolism of endogenous chemical mediators, epoxyeicosatrienoic acids, which are involved in the regulation of blood pressure and inflammation. According to the pharmacophoric model suggested for sEH inhibitors, some new amide-ba...

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Veröffentlicht in:	Molecular diversity 2021-02, Vol.25 (1), p.45-53
Hauptverfasser:	Rezaee, Elham, Amrolah, Somayeh Minaei, Nazari, Maryam, Tabatabai, Sayyed Abbas
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Biochemistry Biomedical and Life Sciences Blood pressure Enzymes Hydrogen bonds Life Sciences Organic Chemistry Original Article Pharmacy Polymer Sciences
Online-Zugang:	Volltext
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