Breast cancer cells promote CD169+ macrophage-associated immunosuppression through JAK2-mediated PD-L1 upregulation on macrophages

[Display omitted] •Depletion of CD169+ macrophages suppresses breast tumor growth and lung metastasis.•Depletion of CD169+ macrophages potentiates anti-tumor T cells.•Breast cancer cells coculture enhances the expression of PD-L1 on CD169+ macrophages.•JAK2 regulates PD-L1 expression in macrophages...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International immunopharmacology 2020-01, Vol.78, p.106012-106012, Article 106012
Hauptverfasser:	Jing, Weiqiang, Guo, Xing, Wang, Ganyu, Bi, Yuxuan, Han, Lihui, Zhu, Qingfen, Qiu, Chunhong, Tanaka, Masato, Zhao, Yunxue
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Bone loss Bone marrow Breast cancer CD169+ macrophages CD8 antigen CD8+ T cells Depletion Erythropoiesis Immunosuppression Immunosurveillance JAK2 Janus kinase 2 L1 protein Lymphocytes Lymphocytes T Macrophages Metastases PD-L1 PD-L1 protein Protein folding Proteins Signal transduction Signaling Spleen Splenomegaly Stat3 protein Triple-negative breast cancer Tumor cells Tumors Up-regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!