One-year changes in brain microstructure differentiate preclinical Huntington's disease stages

•Differences in preHD in one-year MD change in posterior basal ganglia and CC splenium.•Non-monotonic effect driven by MD decrease in FAR group and increase in MID/NEAR.•Only 1 clinical measure shows difference in 1y change between preclinical stages.•Diffusion imaging may detect early signs of infl...

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Veröffentlicht in:	NeuroImage clinical 2020-01, Vol.25, p.102099-102099, Article 102099
Hauptverfasser:	Pflanz, Chris Patrick, Charquero-Ballester, Marina, Majid, D.S. Adnan, Winkler, Anderson M., Vallée, Emmanuel, Aron, Adam R., Jenkinson, Mark, Douaud, Gwenaëlle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Basal ganglia Basal Ganglia - diagnostic imaging Basal Ganglia - pathology Corpus callosum Corpus Callosum - diagnostic imaging Corpus Callosum - pathology Diffusion imaging Diffusion Tensor Imaging - standards Female Humans Huntington Disease - diagnostic imaging Huntington Disease - pathology Life Sciences & Biomedicine Longitudinal Longitudinal Studies Male Microstructure Middle Aged Neuroimaging Neurosciences & Neurology Preclinical Huntington's disease Prodromal Symptoms Regular Science & Technology
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