Is one brachytherapy fraction of 7 Gy similar to more fractions after external beam irradiation in postoperative endometrial carcinoma?
Purpose To determine whether brachytherapy with a single hypofractionated dose of 7 Gy provides the similar vaginal-cuff relapses and safety profile in terms of complications compared to schedules of 2 or 3 fractions of lower doses in patients treated previously with external beam irradiation in pos...
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| Veröffentlicht in: | Clinical & translational oncology 2020-08, Vol.22 (8), p.1295-1302 |
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| creator | Zhang, Y. Ascaso, C. Herreros, A. Sánchez, J. del Pino, M. Torné, A. Li, Y. Sabater, S. Arenas, M. Biete, A. Rovirosa, Á. |
| description | Purpose
To determine whether brachytherapy with a single hypofractionated dose of 7 Gy provides the similar vaginal-cuff relapses and safety profile in terms of complications compared to schedules of 2 or 3 fractions of lower doses in patients treated previously with external beam irradiation in postoperative endometrial carcinoma.
Methods/material
From June 2003 to December 2016, 325 patients were treated with 3 different schedules of high-dose-rate brachytherapy after external beam irradiation for postoperative endometrial carcinoma. The patients were divided into 3 groups: Group-1: 125 patients were treated with 3 fractions of 4–6 Gy per fraction (3 fractions/week) between 2003 and 2008; Group-2: 93 patients were treated with 2 consecutive daily fractions of 5–6 Gy between 2008 and 2011; Group-3: 107 patients received a single fraction of 7 Gy between 2011 and 2016. Bladder and rectum complications were assessed using RTOG scores and with the objective scores of LENT-SOMA for the vagina. Statistics: the chi-square test.
Results
The mean follow-up of Groups 1, 2 and 3 was 95, 67 and 51 months, respectively. Three patients in Group-1, 2 in Group-2, 1 in Group-3 developed vaginal-cuff relapse (
p
= 0.68). No differences were found in late toxicity among the three groups.
Conclusions
One single dose of 7 Gy is safe and effective and may be the best treatment schedule with a similar incidence of vaginal-cuff relapses, complications and patient comfort with less hospital attendance. |
| doi_str_mv | 10.1007/s12094-019-02255-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2330063124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2330063124</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-3e953289a30cf252b419101568d920263925c1ecd2b6c03fe10d2b73080de7ec3</originalsourceid><addsrcrecordid>eNp9kc9O3DAQhy1UxJ-FF-ih8rGXwNiOk_hUVasWkFbqBSRuluNMilESp7a3YnmCPkafpU-GYbd75GLP2N98h_kR8pHBBQOoLyPjoMoCmCqAcymL5wNywiqlCgFSftjVUDb3x-Q0xkfIrxVjR-RYsKaSFZQn5M9NpH5C2gZjHzbpAYOZN7TPXXJ-or6n9b-_Vxsa3egGE2jydPQB90Skpk8YKD7lczIDbdGM1IVgOmfeFG6is4_Jz1md3G-kOHV-xBRcpq0J1k1-NF_OyGFvhojnu3tB7r5_u11eF6sfVzfLr6vCirJOhUAlBW-UEWB7LnlbMsWAyarpFAdeCcWlZWg73lYWRI8MclkLaKDDGq1YkM9b7xz8rzXGpEcXLQ6DmdCvo-ZCAFSC8TKjfIva4GMM2Os5uNGEjWagXxPQ2wR0TkC_JaCf89CnnX_djtjtR_6vPANiC8T8Nf3EoB_9-nV18T3tC0YslMQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2330063124</pqid></control><display><type>article</type><title>Is one brachytherapy fraction of 7 Gy similar to more fractions after external beam irradiation in postoperative endometrial carcinoma?</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Zhang, Y. ; Ascaso, C. ; Herreros, A. ; Sánchez, J. ; del Pino, M. ; Torné, A. ; Li, Y. ; Sabater, S. ; Arenas, M. ; Biete, A. ; Rovirosa, Á.</creator><creatorcontrib>Zhang, Y. ; Ascaso, C. ; Herreros, A. ; Sánchez, J. ; del Pino, M. ; Torné, A. ; Li, Y. ; Sabater, S. ; Arenas, M. ; Biete, A. ; Rovirosa, Á.</creatorcontrib><description>Purpose
To determine whether brachytherapy with a single hypofractionated dose of 7 Gy provides the similar vaginal-cuff relapses and safety profile in terms of complications compared to schedules of 2 or 3 fractions of lower doses in patients treated previously with external beam irradiation in postoperative endometrial carcinoma.
Methods/material
From June 2003 to December 2016, 325 patients were treated with 3 different schedules of high-dose-rate brachytherapy after external beam irradiation for postoperative endometrial carcinoma. The patients were divided into 3 groups: Group-1: 125 patients were treated with 3 fractions of 4–6 Gy per fraction (3 fractions/week) between 2003 and 2008; Group-2: 93 patients were treated with 2 consecutive daily fractions of 5–6 Gy between 2008 and 2011; Group-3: 107 patients received a single fraction of 7 Gy between 2011 and 2016. Bladder and rectum complications were assessed using RTOG scores and with the objective scores of LENT-SOMA for the vagina. Statistics: the chi-square test.
Results
The mean follow-up of Groups 1, 2 and 3 was 95, 67 and 51 months, respectively. Three patients in Group-1, 2 in Group-2, 1 in Group-3 developed vaginal-cuff relapse (
p
= 0.68). No differences were found in late toxicity among the three groups.
Conclusions
One single dose of 7 Gy is safe and effective and may be the best treatment schedule with a similar incidence of vaginal-cuff relapses, complications and patient comfort with less hospital attendance.</description><identifier>ISSN: 1699-048X</identifier><identifier>EISSN: 1699-3055</identifier><identifier>DOI: 10.1007/s12094-019-02255-z</identifier><identifier>PMID: 31865604</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Brachytherapy - methods ; Chi-Square Distribution ; Dose Fractionation, Radiation ; Endometrial Neoplasms - drug therapy ; Endometrial Neoplasms - pathology ; Endometrial Neoplasms - radiotherapy ; Endometrial Neoplasms - surgery ; Female ; Humans ; Medicine ; Medicine & Public Health ; Oncology ; Organs at Risk - radiation effects ; Postoperative Period ; Radiation Dose Hypofractionation ; Rectum - radiation effects ; Research Article ; Urinary Bladder - radiation effects ; Vagina - radiation effects</subject><ispartof>Clinical & translational oncology, 2020-08, Vol.22 (8), p.1295-1302</ispartof><rights>Federación de Sociedades Españolas de Oncología (FESEO) 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-3e953289a30cf252b419101568d920263925c1ecd2b6c03fe10d2b73080de7ec3</citedby><cites>FETCH-LOGICAL-c347t-3e953289a30cf252b419101568d920263925c1ecd2b6c03fe10d2b73080de7ec3</cites><orcidid>0000-0001-9867-481X ; 0000-0002-7965-4757 ; 0000-0002-2379-6174 ; 0000-0003-0111-9540 ; 0000-0002-4895-7616 ; 0000-0003-0815-2570 ; 0000-0003-4700-9507 ; 0000-0001-6049-2025 ; 0000-0002-7832-334X ; 0000-0001-5075-2516</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12094-019-02255-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12094-019-02255-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31865604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Y.</creatorcontrib><creatorcontrib>Ascaso, C.</creatorcontrib><creatorcontrib>Herreros, A.</creatorcontrib><creatorcontrib>Sánchez, J.</creatorcontrib><creatorcontrib>del Pino, M.</creatorcontrib><creatorcontrib>Torné, A.</creatorcontrib><creatorcontrib>Li, Y.</creatorcontrib><creatorcontrib>Sabater, S.</creatorcontrib><creatorcontrib>Arenas, M.</creatorcontrib><creatorcontrib>Biete, A.</creatorcontrib><creatorcontrib>Rovirosa, Á.</creatorcontrib><title>Is one brachytherapy fraction of 7 Gy similar to more fractions after external beam irradiation in postoperative endometrial carcinoma?</title><title>Clinical & translational oncology</title><addtitle>Clin Transl Oncol</addtitle><addtitle>Clin Transl Oncol</addtitle><description>Purpose
To determine whether brachytherapy with a single hypofractionated dose of 7 Gy provides the similar vaginal-cuff relapses and safety profile in terms of complications compared to schedules of 2 or 3 fractions of lower doses in patients treated previously with external beam irradiation in postoperative endometrial carcinoma.
Methods/material
From June 2003 to December 2016, 325 patients were treated with 3 different schedules of high-dose-rate brachytherapy after external beam irradiation for postoperative endometrial carcinoma. The patients were divided into 3 groups: Group-1: 125 patients were treated with 3 fractions of 4–6 Gy per fraction (3 fractions/week) between 2003 and 2008; Group-2: 93 patients were treated with 2 consecutive daily fractions of 5–6 Gy between 2008 and 2011; Group-3: 107 patients received a single fraction of 7 Gy between 2011 and 2016. Bladder and rectum complications were assessed using RTOG scores and with the objective scores of LENT-SOMA for the vagina. Statistics: the chi-square test.
Results
The mean follow-up of Groups 1, 2 and 3 was 95, 67 and 51 months, respectively. Three patients in Group-1, 2 in Group-2, 1 in Group-3 developed vaginal-cuff relapse (
p
= 0.68). No differences were found in late toxicity among the three groups.
Conclusions
One single dose of 7 Gy is safe and effective and may be the best treatment schedule with a similar incidence of vaginal-cuff relapses, complications and patient comfort with less hospital attendance.</description><subject>Aged</subject><subject>Brachytherapy - methods</subject><subject>Chi-Square Distribution</subject><subject>Dose Fractionation, Radiation</subject><subject>Endometrial Neoplasms - drug therapy</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrial Neoplasms - radiotherapy</subject><subject>Endometrial Neoplasms - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Organs at Risk - radiation effects</subject><subject>Postoperative Period</subject><subject>Radiation Dose Hypofractionation</subject><subject>Rectum - radiation effects</subject><subject>Research Article</subject><subject>Urinary Bladder - radiation effects</subject><subject>Vagina - radiation effects</subject><issn>1699-048X</issn><issn>1699-3055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9O3DAQhy1UxJ-FF-ih8rGXwNiOk_hUVasWkFbqBSRuluNMilESp7a3YnmCPkafpU-GYbd75GLP2N98h_kR8pHBBQOoLyPjoMoCmCqAcymL5wNywiqlCgFSftjVUDb3x-Q0xkfIrxVjR-RYsKaSFZQn5M9NpH5C2gZjHzbpAYOZN7TPXXJ-or6n9b-_Vxsa3egGE2jydPQB90Skpk8YKD7lczIDbdGM1IVgOmfeFG6is4_Jz1md3G-kOHV-xBRcpq0J1k1-NF_OyGFvhojnu3tB7r5_u11eF6sfVzfLr6vCirJOhUAlBW-UEWB7LnlbMsWAyarpFAdeCcWlZWg73lYWRI8MclkLaKDDGq1YkM9b7xz8rzXGpEcXLQ6DmdCvo-ZCAFSC8TKjfIva4GMM2Os5uNGEjWagXxPQ2wR0TkC_JaCf89CnnX_djtjtR_6vPANiC8T8Nf3EoB_9-nV18T3tC0YslMQ</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Zhang, Y.</creator><creator>Ascaso, C.</creator><creator>Herreros, A.</creator><creator>Sánchez, J.</creator><creator>del Pino, M.</creator><creator>Torné, A.</creator><creator>Li, Y.</creator><creator>Sabater, S.</creator><creator>Arenas, M.</creator><creator>Biete, A.</creator><creator>Rovirosa, Á.</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9867-481X</orcidid><orcidid>https://orcid.org/0000-0002-7965-4757</orcidid><orcidid>https://orcid.org/0000-0002-2379-6174</orcidid><orcidid>https://orcid.org/0000-0003-0111-9540</orcidid><orcidid>https://orcid.org/0000-0002-4895-7616</orcidid><orcidid>https://orcid.org/0000-0003-0815-2570</orcidid><orcidid>https://orcid.org/0000-0003-4700-9507</orcidid><orcidid>https://orcid.org/0000-0001-6049-2025</orcidid><orcidid>https://orcid.org/0000-0002-7832-334X</orcidid><orcidid>https://orcid.org/0000-0001-5075-2516</orcidid></search><sort><creationdate>20200801</creationdate><title>Is one brachytherapy fraction of 7 Gy similar to more fractions after external beam irradiation in postoperative endometrial carcinoma?</title><author>Zhang, Y. ; Ascaso, C. ; Herreros, A. ; Sánchez, J. ; del Pino, M. ; Torné, A. ; Li, Y. ; Sabater, S. ; Arenas, M. ; Biete, A. ; Rovirosa, Á.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-3e953289a30cf252b419101568d920263925c1ecd2b6c03fe10d2b73080de7ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Brachytherapy - methods</topic><topic>Chi-Square Distribution</topic><topic>Dose Fractionation, Radiation</topic><topic>Endometrial Neoplasms - drug therapy</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrial Neoplasms - radiotherapy</topic><topic>Endometrial Neoplasms - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Organs at Risk - radiation effects</topic><topic>Postoperative Period</topic><topic>Radiation Dose Hypofractionation</topic><topic>Rectum - radiation effects</topic><topic>Research Article</topic><topic>Urinary Bladder - radiation effects</topic><topic>Vagina - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Y.</creatorcontrib><creatorcontrib>Ascaso, C.</creatorcontrib><creatorcontrib>Herreros, A.</creatorcontrib><creatorcontrib>Sánchez, J.</creatorcontrib><creatorcontrib>del Pino, M.</creatorcontrib><creatorcontrib>Torné, A.</creatorcontrib><creatorcontrib>Li, Y.</creatorcontrib><creatorcontrib>Sabater, S.</creatorcontrib><creatorcontrib>Arenas, M.</creatorcontrib><creatorcontrib>Biete, A.</creatorcontrib><creatorcontrib>Rovirosa, Á.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical & translational oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Y.</au><au>Ascaso, C.</au><au>Herreros, A.</au><au>Sánchez, J.</au><au>del Pino, M.</au><au>Torné, A.</au><au>Li, Y.</au><au>Sabater, S.</au><au>Arenas, M.</au><au>Biete, A.</au><au>Rovirosa, Á.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is one brachytherapy fraction of 7 Gy similar to more fractions after external beam irradiation in postoperative endometrial carcinoma?</atitle><jtitle>Clinical & translational oncology</jtitle><stitle>Clin Transl Oncol</stitle><addtitle>Clin Transl Oncol</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>22</volume><issue>8</issue><spage>1295</spage><epage>1302</epage><pages>1295-1302</pages><issn>1699-048X</issn><eissn>1699-3055</eissn><abstract>Purpose
To determine whether brachytherapy with a single hypofractionated dose of 7 Gy provides the similar vaginal-cuff relapses and safety profile in terms of complications compared to schedules of 2 or 3 fractions of lower doses in patients treated previously with external beam irradiation in postoperative endometrial carcinoma.
Methods/material
From June 2003 to December 2016, 325 patients were treated with 3 different schedules of high-dose-rate brachytherapy after external beam irradiation for postoperative endometrial carcinoma. The patients were divided into 3 groups: Group-1: 125 patients were treated with 3 fractions of 4–6 Gy per fraction (3 fractions/week) between 2003 and 2008; Group-2: 93 patients were treated with 2 consecutive daily fractions of 5–6 Gy between 2008 and 2011; Group-3: 107 patients received a single fraction of 7 Gy between 2011 and 2016. Bladder and rectum complications were assessed using RTOG scores and with the objective scores of LENT-SOMA for the vagina. Statistics: the chi-square test.
Results
The mean follow-up of Groups 1, 2 and 3 was 95, 67 and 51 months, respectively. Three patients in Group-1, 2 in Group-2, 1 in Group-3 developed vaginal-cuff relapse (
p
= 0.68). No differences were found in late toxicity among the three groups.
Conclusions
One single dose of 7 Gy is safe and effective and may be the best treatment schedule with a similar incidence of vaginal-cuff relapses, complications and patient comfort with less hospital attendance.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31865604</pmid><doi>10.1007/s12094-019-02255-z</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9867-481X</orcidid><orcidid>https://orcid.org/0000-0002-7965-4757</orcidid><orcidid>https://orcid.org/0000-0002-2379-6174</orcidid><orcidid>https://orcid.org/0000-0003-0111-9540</orcidid><orcidid>https://orcid.org/0000-0002-4895-7616</orcidid><orcidid>https://orcid.org/0000-0003-0815-2570</orcidid><orcidid>https://orcid.org/0000-0003-4700-9507</orcidid><orcidid>https://orcid.org/0000-0001-6049-2025</orcidid><orcidid>https://orcid.org/0000-0002-7832-334X</orcidid><orcidid>https://orcid.org/0000-0001-5075-2516</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1699-048X |
| ispartof | Clinical & translational oncology, 2020-08, Vol.22 (8), p.1295-1302 |
| issn | 1699-048X 1699-3055 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Brachytherapy - methods Chi-Square Distribution Dose Fractionation, Radiation Endometrial Neoplasms - drug therapy Endometrial Neoplasms - pathology Endometrial Neoplasms - radiotherapy Endometrial Neoplasms - surgery Female Humans Medicine Medicine & Public Health Oncology Organs at Risk - radiation effects Postoperative Period Radiation Dose Hypofractionation Rectum - radiation effects Research Article Urinary Bladder - radiation effects Vagina - radiation effects |
| title | Is one brachytherapy fraction of 7 Gy similar to more fractions after external beam irradiation in postoperative endometrial carcinoma? |
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