Unilateral primary aldosteronism as an independent risk factor for vertebral fracture
Context Primary aldosteronism (PA) is known to increase vertebral fracture (VF), although the detailed mechanism remains to be elucidated. We hypothesized that the PA subtype is associated with VF. Objective To evaluate whether unilateral PA is associated with the prevalence of VF. Design This was a...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2020-03, Vol.92 (3), p.206-213 |
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| creator | Yokomoto‐Umakoshi, Maki Sakamoto, Ryuichi Umakoshi, Hironobu Matsuda, Yayoi Nagata, Hiromi Fukumoto, Tazuru Ogata, Masatoshi Ogawa, Yoshihiro |
| description | Context
Primary aldosteronism (PA) is known to increase vertebral fracture (VF), although the detailed mechanism remains to be elucidated. We hypothesized that the PA subtype is associated with VF.
Objective
To evaluate whether unilateral PA is associated with the prevalence of VF.
Design
This was a retrospective cross‐sectional study in a single referral centre.
Patients
We identified 210 hypertensive patients whose clinical data were available for case‐detection results. One hundred and fifty‐two patients were diagnosed with PA using captopril challenge tests.
Measurements
We measured the prevalence of VF, according to PA subtype.
Results
One hundred thirteen patients with PA were subtype classified by adrenal vein sampling. Of these, 37 patients had unilateral PA, 76 patients had bilateral PA, 58 patients had non‐PA; 39 patients with PA were not subtype‐classified. Patients with PA had a higher prevalence of VF (29%, 44/152) than those with non‐PA (12%, 7/58; P = .011). Moreover, unilateral PA had a higher prevalence of VF (46%, 17/37) than bilateral PA (20%, 15/76; P = .021). There was no significant difference in the prevalence of VF between bilateral PA and non‐PA. Unilateral PA was an independent risk factor for VF after adjusting for age and sex (OR: 3.16, 95% confidence interval: 1.12‐8.92; P = .017). Among patients with unilateral PA, serum cortisol concentrations after 1‐mg dexamethasone suppression test were higher in those with VF (1.32 ± 0.67 g/dL) than those without (0.96 ± 0.33 g/dL; P = .048).
Conclusions
Unilateral PA is an independent risk factor for VF. |
| doi_str_mv | 10.1111/cen.14145 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2330061418</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2330061418</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4195-934ed17f7ab82bc2ed7e83492dbed4f8d4ee4cb6a50f58a2ee6df1718215613b3</originalsourceid><addsrcrecordid>eNp1kE1LwzAYgIMobk4P_gEpeNFDt3w3PcqYHzD04s4lbd5AZ5fOpFX2783s9CAYSAIvDw8vD0KXBE9JPLMK3JRwwsURGhMmRUqpFMdojBnGKZaSj9BZCGuMsVA4O0UjRpRUOcvHaLVydaM78LpJtr7eaL9LdGPaEEetq8Mm0SHRLqmdgS3Ex3WJr8NbYnXVtT6x8X6A76DcG6yP097DOTqxuglwcfgnaHW_eJ0_psuXh6f53TKtOMlFmjMOhmQ206WiZUXBZKAYz6kpwXCrDAfgVSm1wFYoTQGksSQjihIhCSvZBN0M3q1v33sIXbGpQwVNox20fSgoiwVkTKMiev0HXbe9d3G7SAnGqWRyT90OVOXbEDzY4hClILjYty5i6-K7dWSvDsa-3ID5JX_iRmA2AJ91A7v_TcV88TwovwB4N4jd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2353426368</pqid></control><display><type>article</type><title>Unilateral primary aldosteronism as an independent risk factor for vertebral fracture</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Yokomoto‐Umakoshi, Maki ; Sakamoto, Ryuichi ; Umakoshi, Hironobu ; Matsuda, Yayoi ; Nagata, Hiromi ; Fukumoto, Tazuru ; Ogata, Masatoshi ; Ogawa, Yoshihiro</creator><creatorcontrib>Yokomoto‐Umakoshi, Maki ; Sakamoto, Ryuichi ; Umakoshi, Hironobu ; Matsuda, Yayoi ; Nagata, Hiromi ; Fukumoto, Tazuru ; Ogata, Masatoshi ; Ogawa, Yoshihiro ; Q-AND-A study group ; the Q‐AND‐A study group</creatorcontrib><description>Context
Primary aldosteronism (PA) is known to increase vertebral fracture (VF), although the detailed mechanism remains to be elucidated. We hypothesized that the PA subtype is associated with VF.
Objective
To evaluate whether unilateral PA is associated with the prevalence of VF.
Design
This was a retrospective cross‐sectional study in a single referral centre.
Patients
We identified 210 hypertensive patients whose clinical data were available for case‐detection results. One hundred and fifty‐two patients were diagnosed with PA using captopril challenge tests.
Measurements
We measured the prevalence of VF, according to PA subtype.
Results
One hundred thirteen patients with PA were subtype classified by adrenal vein sampling. Of these, 37 patients had unilateral PA, 76 patients had bilateral PA, 58 patients had non‐PA; 39 patients with PA were not subtype‐classified. Patients with PA had a higher prevalence of VF (29%, 44/152) than those with non‐PA (12%, 7/58; P = .011). Moreover, unilateral PA had a higher prevalence of VF (46%, 17/37) than bilateral PA (20%, 15/76; P = .021). There was no significant difference in the prevalence of VF between bilateral PA and non‐PA. Unilateral PA was an independent risk factor for VF after adjusting for age and sex (OR: 3.16, 95% confidence interval: 1.12‐8.92; P = .017). Among patients with unilateral PA, serum cortisol concentrations after 1‐mg dexamethasone suppression test were higher in those with VF (1.32 ± 0.67 g/dL) than those without (0.96 ± 0.33 g/dL; P = .048).
Conclusions
Unilateral PA is an independent risk factor for VF.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.14145</identifier><identifier>PMID: 31868939</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aldosterone - blood ; Case-Control Studies ; Cortisol ; Cross-Sectional Studies ; Dexamethasone ; Endocrine disorders ; Female ; Humans ; Hyperaldosteronism - complications ; Hyperaldosteronism - epidemiology ; Hypertension - blood ; Hypertension - epidemiology ; Hypertension - etiology ; Japan - epidemiology ; Male ; Middle Aged ; Osteoporosis ; Prevalence ; Retrospective Studies ; Risk Factors ; Spinal Fractures - epidemiology ; Spinal Fractures - etiology ; unilateral primary aldosteronism ; Vertebrae ; vertebral fracture</subject><ispartof>Clinical endocrinology (Oxford), 2020-03, Vol.92 (3), p.206-213</ispartof><rights>2019 John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4195-934ed17f7ab82bc2ed7e83492dbed4f8d4ee4cb6a50f58a2ee6df1718215613b3</citedby><cites>FETCH-LOGICAL-c4195-934ed17f7ab82bc2ed7e83492dbed4f8d4ee4cb6a50f58a2ee6df1718215613b3</cites><orcidid>0000-0003-4293-287X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.14145$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.14145$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31868939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yokomoto‐Umakoshi, Maki</creatorcontrib><creatorcontrib>Sakamoto, Ryuichi</creatorcontrib><creatorcontrib>Umakoshi, Hironobu</creatorcontrib><creatorcontrib>Matsuda, Yayoi</creatorcontrib><creatorcontrib>Nagata, Hiromi</creatorcontrib><creatorcontrib>Fukumoto, Tazuru</creatorcontrib><creatorcontrib>Ogata, Masatoshi</creatorcontrib><creatorcontrib>Ogawa, Yoshihiro</creatorcontrib><creatorcontrib>Q-AND-A study group</creatorcontrib><creatorcontrib>the Q‐AND‐A study group</creatorcontrib><title>Unilateral primary aldosteronism as an independent risk factor for vertebral fracture</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Context
Primary aldosteronism (PA) is known to increase vertebral fracture (VF), although the detailed mechanism remains to be elucidated. We hypothesized that the PA subtype is associated with VF.
Objective
To evaluate whether unilateral PA is associated with the prevalence of VF.
Design
This was a retrospective cross‐sectional study in a single referral centre.
Patients
We identified 210 hypertensive patients whose clinical data were available for case‐detection results. One hundred and fifty‐two patients were diagnosed with PA using captopril challenge tests.
Measurements
We measured the prevalence of VF, according to PA subtype.
Results
One hundred thirteen patients with PA were subtype classified by adrenal vein sampling. Of these, 37 patients had unilateral PA, 76 patients had bilateral PA, 58 patients had non‐PA; 39 patients with PA were not subtype‐classified. Patients with PA had a higher prevalence of VF (29%, 44/152) than those with non‐PA (12%, 7/58; P = .011). Moreover, unilateral PA had a higher prevalence of VF (46%, 17/37) than bilateral PA (20%, 15/76; P = .021). There was no significant difference in the prevalence of VF between bilateral PA and non‐PA. Unilateral PA was an independent risk factor for VF after adjusting for age and sex (OR: 3.16, 95% confidence interval: 1.12‐8.92; P = .017). Among patients with unilateral PA, serum cortisol concentrations after 1‐mg dexamethasone suppression test were higher in those with VF (1.32 ± 0.67 g/dL) than those without (0.96 ± 0.33 g/dL; P = .048).
Conclusions
Unilateral PA is an independent risk factor for VF.</description><subject>Adult</subject><subject>Aged</subject><subject>Aldosterone - blood</subject><subject>Case-Control Studies</subject><subject>Cortisol</subject><subject>Cross-Sectional Studies</subject><subject>Dexamethasone</subject><subject>Endocrine disorders</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperaldosteronism - complications</subject><subject>Hyperaldosteronism - epidemiology</subject><subject>Hypertension - blood</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - etiology</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteoporosis</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Spinal Fractures - epidemiology</subject><subject>Spinal Fractures - etiology</subject><subject>unilateral primary aldosteronism</subject><subject>Vertebrae</subject><subject>vertebral fracture</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LwzAYgIMobk4P_gEpeNFDt3w3PcqYHzD04s4lbd5AZ5fOpFX2783s9CAYSAIvDw8vD0KXBE9JPLMK3JRwwsURGhMmRUqpFMdojBnGKZaSj9BZCGuMsVA4O0UjRpRUOcvHaLVydaM78LpJtr7eaL9LdGPaEEetq8Mm0SHRLqmdgS3Ex3WJr8NbYnXVtT6x8X6A76DcG6yP097DOTqxuglwcfgnaHW_eJ0_psuXh6f53TKtOMlFmjMOhmQ206WiZUXBZKAYz6kpwXCrDAfgVSm1wFYoTQGksSQjihIhCSvZBN0M3q1v33sIXbGpQwVNox20fSgoiwVkTKMiev0HXbe9d3G7SAnGqWRyT90OVOXbEDzY4hClILjYty5i6-K7dWSvDsa-3ID5JX_iRmA2AJ91A7v_TcV88TwovwB4N4jd</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Yokomoto‐Umakoshi, Maki</creator><creator>Sakamoto, Ryuichi</creator><creator>Umakoshi, Hironobu</creator><creator>Matsuda, Yayoi</creator><creator>Nagata, Hiromi</creator><creator>Fukumoto, Tazuru</creator><creator>Ogata, Masatoshi</creator><creator>Ogawa, Yoshihiro</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4293-287X</orcidid></search><sort><creationdate>202003</creationdate><title>Unilateral primary aldosteronism as an independent risk factor for vertebral fracture</title><author>Yokomoto‐Umakoshi, Maki ; Sakamoto, Ryuichi ; Umakoshi, Hironobu ; Matsuda, Yayoi ; Nagata, Hiromi ; Fukumoto, Tazuru ; Ogata, Masatoshi ; Ogawa, Yoshihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4195-934ed17f7ab82bc2ed7e83492dbed4f8d4ee4cb6a50f58a2ee6df1718215613b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aldosterone - blood</topic><topic>Case-Control Studies</topic><topic>Cortisol</topic><topic>Cross-Sectional Studies</topic><topic>Dexamethasone</topic><topic>Endocrine disorders</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperaldosteronism - complications</topic><topic>Hyperaldosteronism - epidemiology</topic><topic>Hypertension - blood</topic><topic>Hypertension - epidemiology</topic><topic>Hypertension - etiology</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osteoporosis</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Spinal Fractures - epidemiology</topic><topic>Spinal Fractures - etiology</topic><topic>unilateral primary aldosteronism</topic><topic>Vertebrae</topic><topic>vertebral fracture</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yokomoto‐Umakoshi, Maki</creatorcontrib><creatorcontrib>Sakamoto, Ryuichi</creatorcontrib><creatorcontrib>Umakoshi, Hironobu</creatorcontrib><creatorcontrib>Matsuda, Yayoi</creatorcontrib><creatorcontrib>Nagata, Hiromi</creatorcontrib><creatorcontrib>Fukumoto, Tazuru</creatorcontrib><creatorcontrib>Ogata, Masatoshi</creatorcontrib><creatorcontrib>Ogawa, Yoshihiro</creatorcontrib><creatorcontrib>Q-AND-A study group</creatorcontrib><creatorcontrib>the Q‐AND‐A study group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yokomoto‐Umakoshi, Maki</au><au>Sakamoto, Ryuichi</au><au>Umakoshi, Hironobu</au><au>Matsuda, Yayoi</au><au>Nagata, Hiromi</au><au>Fukumoto, Tazuru</au><au>Ogata, Masatoshi</au><au>Ogawa, Yoshihiro</au><aucorp>Q-AND-A study group</aucorp><aucorp>the Q‐AND‐A study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unilateral primary aldosteronism as an independent risk factor for vertebral fracture</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2020-03</date><risdate>2020</risdate><volume>92</volume><issue>3</issue><spage>206</spage><epage>213</epage><pages>206-213</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Context
Primary aldosteronism (PA) is known to increase vertebral fracture (VF), although the detailed mechanism remains to be elucidated. We hypothesized that the PA subtype is associated with VF.
Objective
To evaluate whether unilateral PA is associated with the prevalence of VF.
Design
This was a retrospective cross‐sectional study in a single referral centre.
Patients
We identified 210 hypertensive patients whose clinical data were available for case‐detection results. One hundred and fifty‐two patients were diagnosed with PA using captopril challenge tests.
Measurements
We measured the prevalence of VF, according to PA subtype.
Results
One hundred thirteen patients with PA were subtype classified by adrenal vein sampling. Of these, 37 patients had unilateral PA, 76 patients had bilateral PA, 58 patients had non‐PA; 39 patients with PA were not subtype‐classified. Patients with PA had a higher prevalence of VF (29%, 44/152) than those with non‐PA (12%, 7/58; P = .011). Moreover, unilateral PA had a higher prevalence of VF (46%, 17/37) than bilateral PA (20%, 15/76; P = .021). There was no significant difference in the prevalence of VF between bilateral PA and non‐PA. Unilateral PA was an independent risk factor for VF after adjusting for age and sex (OR: 3.16, 95% confidence interval: 1.12‐8.92; P = .017). Among patients with unilateral PA, serum cortisol concentrations after 1‐mg dexamethasone suppression test were higher in those with VF (1.32 ± 0.67 g/dL) than those without (0.96 ± 0.33 g/dL; P = .048).
Conclusions
Unilateral PA is an independent risk factor for VF.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31868939</pmid><doi>10.1111/cen.14145</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4293-287X</orcidid></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 2020-03, Vol.92 (3), p.206-213 |
| issn | 0300-0664 1365-2265 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Aged Aldosterone - blood Case-Control Studies Cortisol Cross-Sectional Studies Dexamethasone Endocrine disorders Female Humans Hyperaldosteronism - complications Hyperaldosteronism - epidemiology Hypertension - blood Hypertension - epidemiology Hypertension - etiology Japan - epidemiology Male Middle Aged Osteoporosis Prevalence Retrospective Studies Risk Factors Spinal Fractures - epidemiology Spinal Fractures - etiology unilateral primary aldosteronism Vertebrae vertebral fracture |
| title | Unilateral primary aldosteronism as an independent risk factor for vertebral fracture |
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