Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of rapamycin (mTOR) represent two vital intracellular signaling pathways, which are associated with various aspects of cellular functions. These functions play vital roles in quiescence, survival, and growth in normal physiologica...

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Veröffentlicht in:	Seminars in cancer biology 2022-05, Vol.80, p.1-17
Hauptverfasser:	Tewari, Devesh, Patni, Pooja, Bishayee, Anusha, Sah, Archana N., Bishayee, Anupam
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Products - pharmacology Biological Products - therapeutic use Breast cancer Humans Lymphoma mTOR Natural compounds Neoplasms - drug therapy Phosphatidylinositol 3-Kinase - metabolism Phosphatidylinositol 3-Kinase - pharmacology Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors - therapeutic use Phytochemicals PI3K-Akt Polyphenols Prostate cancer Proto-Oncogene Proteins c-akt - metabolism Sarcoma Signal Transduction TOR Serine-Threonine Kinases - metabolism
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