Treatment strategies for metastatic gastric cancer: chemotherapy, palliative surgery or radiotherapy?
This study explored whether chemotherapy combined with palliative surgery and/or radiotherapy is a possible treatment for metastatic gastric cancer. Patients were divided into groups according to treatments. COX models were used to explore prognostic factors. Kaplan–Meier models and log-rank tests w...
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| Veröffentlicht in: | Future oncology (London, England) England), 2020-02, Vol.16 (5), p.91-102 |
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| container_title | Future oncology (London, England) |
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| creator | Liang, Xiao Zhu, Jiamin Li, Yuanye Xu, Yiren Chen, Kai Lv, Liting Mao, Weidong |
| description | This study explored whether chemotherapy combined with palliative surgery and/or radiotherapy is a possible treatment for metastatic gastric cancer.
Patients were divided into groups according to treatments. COX models were used to explore prognostic factors. Kaplan–Meier models and log-rank tests were used to analyze outcomes. Outcomes were analyzed before and after propensity score matching.
Chemotherapy combined with gastrectomy or metastasectomy prolongs the survival time compared with chemotherapy alone (p < 0.05). Chemotherapy combined with gastrectomy plus metastasectomy and/or radiation therapy also prolongs the survival time (p < 0.05).
Chemotherapy combined with gastrectomy could be a more effective treatment for metastatic gastric cancer. Chemotherapy combined with gastrectomy plus metastasectomy and/or radiation therapy could also be a promising treatment. |
| doi_str_mv | 10.2217/fon-2019-0495 |
| format | Article |
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Patients were divided into groups according to treatments. COX models were used to explore prognostic factors. Kaplan–Meier models and log-rank tests were used to analyze outcomes. Outcomes were analyzed before and after propensity score matching.
Chemotherapy combined with gastrectomy or metastasectomy prolongs the survival time compared with chemotherapy alone (p < 0.05). Chemotherapy combined with gastrectomy plus metastasectomy and/or radiation therapy also prolongs the survival time (p < 0.05).
Chemotherapy combined with gastrectomy could be a more effective treatment for metastatic gastric cancer. Chemotherapy combined with gastrectomy plus metastasectomy and/or radiation therapy could also be a promising treatment.</description><identifier>ISSN: 1479-6694</identifier><identifier>EISSN: 1744-8301</identifier><identifier>DOI: 10.2217/fon-2019-0495</identifier><identifier>PMID: 31868545</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Age ; Cancer therapies ; Chemotherapy ; Gastric cancer ; Histology ; Medical prognosis ; Metastasis ; metastatic gastric cancer ; Multivariate analysis ; Radiation therapy ; SEER ; Surgery ; treatment strategies</subject><ispartof>Future oncology (London, England), 2020-02, Vol.16 (5), p.91-102</ispartof><rights>2019 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Feb 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-be80e540ac05913d9ac605d46cee175a20532d764063f253be1ef534682c009f3</citedby><cites>FETCH-LOGICAL-c371t-be80e540ac05913d9ac605d46cee175a20532d764063f253be1ef534682c009f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31868545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Xiao</creatorcontrib><creatorcontrib>Zhu, Jiamin</creatorcontrib><creatorcontrib>Li, Yuanye</creatorcontrib><creatorcontrib>Xu, Yiren</creatorcontrib><creatorcontrib>Chen, Kai</creatorcontrib><creatorcontrib>Lv, Liting</creatorcontrib><creatorcontrib>Mao, Weidong</creatorcontrib><title>Treatment strategies for metastatic gastric cancer: chemotherapy, palliative surgery or radiotherapy?</title><title>Future oncology (London, England)</title><addtitle>Future Oncol</addtitle><description>This study explored whether chemotherapy combined with palliative surgery and/or radiotherapy is a possible treatment for metastatic gastric cancer.
Patients were divided into groups according to treatments. COX models were used to explore prognostic factors. Kaplan–Meier models and log-rank tests were used to analyze outcomes. Outcomes were analyzed before and after propensity score matching.
Chemotherapy combined with gastrectomy or metastasectomy prolongs the survival time compared with chemotherapy alone (p < 0.05). Chemotherapy combined with gastrectomy plus metastasectomy and/or radiation therapy also prolongs the survival time (p < 0.05).
Chemotherapy combined with gastrectomy could be a more effective treatment for metastatic gastric cancer. Chemotherapy combined with gastrectomy plus metastasectomy and/or radiation therapy could also be a promising treatment.</description><subject>Age</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Gastric cancer</subject><subject>Histology</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>metastatic gastric cancer</subject><subject>Multivariate analysis</subject><subject>Radiation therapy</subject><subject>SEER</subject><subject>Surgery</subject><subject>treatment strategies</subject><issn>1479-6694</issn><issn>1744-8301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kElLBDEQRoMo7kev0uDFg62VtTteRMQNBC96Dpl09RjpZUzSwvx7M4x6EDxVFbzvo3iEHFE4Z4xWF-04lAyoLkFouUF2aSVEWXOgm3kXlS6V0mKH7MX4DiAqLmGb7HBaq1oKuUvwJaBNPQ6piCnYhHOPsWjHUPSYbEw2eVfM8xLydHZwGC4L94b9mN4w2MXyrFjYrvOZ-8QiTmGOYVnkeLCN_2GuDshWa7uIh99zn7ze3b7cPJRPz_ePN9dPpeMVTeUMa0ApwDqQmvJGW6dANkI5RFpJy0By1lRKgOItk3yGFFvJhaqZA9At3yen695FGD8mjMn0PjrsOjvgOEXDOIdcLSqV0ZM_6Ps4hSF_Z1jWxHU2pTNVrikXxhgDtmYRfG_D0lAwK_8m-zcr_2blP_PH363TrMfml_4RngG9BtopTQGj85idmvWVE975Af8p_wIGfpUD</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Liang, Xiao</creator><creator>Zhu, Jiamin</creator><creator>Li, Yuanye</creator><creator>Xu, Yiren</creator><creator>Chen, Kai</creator><creator>Lv, Liting</creator><creator>Mao, Weidong</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200201</creationdate><title>Treatment strategies for metastatic gastric cancer: chemotherapy, palliative surgery or radiotherapy?</title><author>Liang, Xiao ; Zhu, Jiamin ; Li, Yuanye ; Xu, Yiren ; Chen, Kai ; Lv, Liting ; Mao, Weidong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-be80e540ac05913d9ac605d46cee175a20532d764063f253be1ef534682c009f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Gastric cancer</topic><topic>Histology</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>metastatic gastric cancer</topic><topic>Multivariate analysis</topic><topic>Radiation therapy</topic><topic>SEER</topic><topic>Surgery</topic><topic>treatment strategies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Xiao</creatorcontrib><creatorcontrib>Zhu, Jiamin</creatorcontrib><creatorcontrib>Li, Yuanye</creatorcontrib><creatorcontrib>Xu, Yiren</creatorcontrib><creatorcontrib>Chen, Kai</creatorcontrib><creatorcontrib>Lv, Liting</creatorcontrib><creatorcontrib>Mao, Weidong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Future oncology (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Xiao</au><au>Zhu, Jiamin</au><au>Li, Yuanye</au><au>Xu, Yiren</au><au>Chen, Kai</au><au>Lv, Liting</au><au>Mao, Weidong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment strategies for metastatic gastric cancer: chemotherapy, palliative surgery or radiotherapy?</atitle><jtitle>Future oncology (London, England)</jtitle><addtitle>Future Oncol</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>16</volume><issue>5</issue><spage>91</spage><epage>102</epage><pages>91-102</pages><issn>1479-6694</issn><eissn>1744-8301</eissn><abstract>This study explored whether chemotherapy combined with palliative surgery and/or radiotherapy is a possible treatment for metastatic gastric cancer.
Patients were divided into groups according to treatments. COX models were used to explore prognostic factors. Kaplan–Meier models and log-rank tests were used to analyze outcomes. Outcomes were analyzed before and after propensity score matching.
Chemotherapy combined with gastrectomy or metastasectomy prolongs the survival time compared with chemotherapy alone (p < 0.05). Chemotherapy combined with gastrectomy plus metastasectomy and/or radiation therapy also prolongs the survival time (p < 0.05).
Chemotherapy combined with gastrectomy could be a more effective treatment for metastatic gastric cancer. Chemotherapy combined with gastrectomy plus metastasectomy and/or radiation therapy could also be a promising treatment.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>31868545</pmid><doi>10.2217/fon-2019-0495</doi><tpages>12</tpages></addata></record> |
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| language | eng |
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| source | PubMed Central |
| subjects | Age Cancer therapies Chemotherapy Gastric cancer Histology Medical prognosis Metastasis metastatic gastric cancer Multivariate analysis Radiation therapy SEER Surgery treatment strategies |
| title | Treatment strategies for metastatic gastric cancer: chemotherapy, palliative surgery or radiotherapy? |
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