Are HHV-6A and HHV-7 Really More Abundant in Alzheimer’s Disease?

[...]highly significant p values were ascribed to data where differences were not visually appreciable (Figure S1A), and the p values were inconsistent with simple logistic regression. [...]the values represented in Figure 2 are actually t-statistic values instead of the “Signed –log10(p value)” lab...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2019-12, Vol.104 (6), p.1034-1035
Hauptverfasser: Jeong, Hyun-Hwan, Liu, Zhandong
Format: Artikel
Sprache:eng
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Zusammenfassung:[...]highly significant p values were ascribed to data where differences were not visually appreciable (Figure S1A), and the p values were inconsistent with simple logistic regression. [...]the values represented in Figure 2 are actually t-statistic values instead of the “Signed –log10(p value)” labeled in the panels.Lack of Statistical Robustness We next analyzed the raw input dataset provided by the authors at SynapseID: syn12177272 (MSBB_RNA_workspace.RData). [...]the extremely low expression levels of viral RNA and DNA in these brain samples poses a problem of detection limits.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2019.11.009