Next-generation sequencing implicates oncogenic roles for p53 and JAK/STAT signaling in microcystic adnexal carcinomas

Microcystic adnexal carcinoma is a locally aggressive sweat gland carcinoma characterized by its infiltrative growth and histopathologic overlap with benign adnexal tumors, often posing challenges to both diagnosis and management. Understanding the molecular underpinnings of microcystic adnexal carc...

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Veröffentlicht in:	Modern pathology 2020-06, Vol.33 (6), p.1092-1103
Hauptverfasser:	Chan, May P., Plouffe, Komal R., Liu, Chia-Jen, Palanisamy, Nallasivam, Carskadon, Shannon, Zhao, Lili, Nazarian, Rosalynn M., Durham, Alison B., Johnson, Timothy M., Andea, Aleodor A., Patel, Rajiv M., Lowe, Lori, Fullen, Douglas R., Brown, Noah A., Tomlins, Scott A., Udager, Aaron M., Harms, Paul W.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 692/420/755 692/699/67/69 82/51 Adult Aged Aged, 80 and over Biomarkers, Tumor Carcinoma Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Copy number Dermis Diagnosis DNA sequencing Female High-Throughput Nucleotide Sequencing Humans Immunohistochemistry Janus kinase Janus Kinases - metabolism Kinases Laboratory Medicine Male Medicine Medicine & Public Health Middle Aged Mutation Next-generation sequencing Nucleotide sequence p53 Protein Pathology Phosphorylation Signal Transduction - physiology Skin cancer STAT Transcription Factors - metabolism Stat3 protein Sweat gland Sweat Gland Neoplasms - genetics Sweat Gland Neoplasms - metabolism Sweat Gland Neoplasms - pathology Therapeutic targets Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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