A retrospective study of bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: is it useful to repeat bone scintigraphy for disease assessment?
Objectives To investigate the value of repeated bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome and to characterize the changing pattern of osteoarticular lesions revealed by bone scintigraphy. Method Twenty-four patients w...
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| Veröffentlicht in: | Clinical rheumatology 2020-04, Vol.39 (4), p.1305-1314 |
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| creator | Li, Chen Wang, Lun Wu, Nan Cao, Yihan Sun, Xiaochuan Zhang, Wen Jing, Hongli |
| description | Objectives
To investigate the value of repeated bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome and to characterize the changing pattern of osteoarticular lesions revealed by bone scintigraphy.
Method
Twenty-four patients with SAPHO syndrome who had repetitively undergone bone scintigraphy and tests of inflammatory markers (erythrocyte sedimentation rate (ESR) and/or C-reactive protein (CRP)) were included in this retrospective study. The change in accumulation number was recorded as the difference in the number of accumulation sites between consecutive bone scintigraphy. The visual analog scale (VAS) for pain and medications prescribed were also reviewed. The relationships of the change in accumulation number with medication prescribed and change in ESR or CRP were analyzed.
Results
Twenty-four and 23 patients had follow-up tests of ESR and CRP, from which 30 and 28 follow-up data were obtained, containing the corresponding changes in ESR and CRP, respectively. A decrease in total accumulation number observed by bone scintigraphy was rarely observed, while decreases in ESR, CRP, and VAS were predominant. The accumulation number had significantly increased over time (follow-up with ESR: r = 0.389,
p
= 0.034; follow-up with CRP: r = 0.438,
p
= 0.020), in accordance with an “imprinting” pattern, while the inflammatory markers and VAS for pain predominantly decreased. There was no significant association between the change in accumulation number (local/total) and the change in ESR or CRP values (
p
> 0.05) or medications used for SAPHO (
p
> 0.05).
Conclusions
This retrospective cohort study of 24 SAPHO patients demonstrated an “imprinting” pattern on bone scintigraphy, without a correlation to the decrease in inflammatory markers, patient disease assessment, or treatment type. Thus, repeated bone scintigraphy did not contribute an additional clinical value for the follow-up of patients with SAPHO.
Key Points
•
In a cohort of 24 SAPHO patients, repeated bone scintigraphy revealed a continuous increase in tracer accumulation number, indicating an “imprinting” pattern.
•
The change in tracer accumulation number, defined as the difference in the number of accumulation sites between consecutive bone scintigraphy measurements, was inconsistent with the change in ESR, CRP, or VAS for pain.
•
The medications prescribed for SAPHO did not seem to contribute to a decrease in accumulation n |
| doi_str_mv | 10.1007/s10067-019-04864-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2329739920</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2329739920</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-4630bb687239a5aec122a5ec41e94ecece786848afdce68d935534550a11ff673</originalsourceid><addsrcrecordid>eNp9kV9r1jAUxoMo7nX6BbyQgDderJo0TZN4M8aYf2DgjV6XvO3p3ow2qTnpRvcl_UpL7VQQkUDCk_zOcw55CHnJ2VvOmHqHea9VwbgpWKXrqrh7RHa8ElVhTGUekx1TihWCG31EniFeM8ZKbfhTciS4llqIekd-nNEIKQacoE3uBiimuVto6Ok--Kxa55O7inY6LNR5mg5A-zAM4baYp5WabHLgE9Jblw4UFx9uXHJ4Qm3r4YROc_YbAq43h2WC3ChtyvqOZgErvdZ1MYzwnmbhEp0R-nmgKeThJrDpH8P0IdLOIVgEahEBccxznD4nT3o7ILx4OI_Jtw8XX88_FZdfPn4-P7ssWqFkKqpasP2-1qoUxkoLLS9LK6GtOJgK2ryUrnWlbd-1UOvOCClFJSWznPd9rcQxebP5TjF8nwFTMzpsYRishzBjU4rSKGFMyTL6-i_0OszR5-kypZWURjGZqXKj2vxHGKFvpuhGG5eGs2aNu9nibnLczc-4m7tc9OrBet6P0P0u-ZVvBsQGYH7yVxD_9P6P7T0EFbvc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2387559705</pqid></control><display><type>article</type><title>A retrospective study of bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: is it useful to repeat bone scintigraphy for disease assessment?</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Li, Chen ; Wang, Lun ; Wu, Nan ; Cao, Yihan ; Sun, Xiaochuan ; Zhang, Wen ; Jing, Hongli</creator><creatorcontrib>Li, Chen ; Wang, Lun ; Wu, Nan ; Cao, Yihan ; Sun, Xiaochuan ; Zhang, Wen ; Jing, Hongli</creatorcontrib><description>Objectives
To investigate the value of repeated bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome and to characterize the changing pattern of osteoarticular lesions revealed by bone scintigraphy.
Method
Twenty-four patients with SAPHO syndrome who had repetitively undergone bone scintigraphy and tests of inflammatory markers (erythrocyte sedimentation rate (ESR) and/or C-reactive protein (CRP)) were included in this retrospective study. The change in accumulation number was recorded as the difference in the number of accumulation sites between consecutive bone scintigraphy. The visual analog scale (VAS) for pain and medications prescribed were also reviewed. The relationships of the change in accumulation number with medication prescribed and change in ESR or CRP were analyzed.
Results
Twenty-four and 23 patients had follow-up tests of ESR and CRP, from which 30 and 28 follow-up data were obtained, containing the corresponding changes in ESR and CRP, respectively. A decrease in total accumulation number observed by bone scintigraphy was rarely observed, while decreases in ESR, CRP, and VAS were predominant. The accumulation number had significantly increased over time (follow-up with ESR: r = 0.389,
p
= 0.034; follow-up with CRP: r = 0.438,
p
= 0.020), in accordance with an “imprinting” pattern, while the inflammatory markers and VAS for pain predominantly decreased. There was no significant association between the change in accumulation number (local/total) and the change in ESR or CRP values (
p
> 0.05) or medications used for SAPHO (
p
> 0.05).
Conclusions
This retrospective cohort study of 24 SAPHO patients demonstrated an “imprinting” pattern on bone scintigraphy, without a correlation to the decrease in inflammatory markers, patient disease assessment, or treatment type. Thus, repeated bone scintigraphy did not contribute an additional clinical value for the follow-up of patients with SAPHO.
Key Points
•
In a cohort of 24 SAPHO patients, repeated bone scintigraphy revealed a continuous increase in tracer accumulation number, indicating an “imprinting” pattern.
•
The change in tracer accumulation number, defined as the difference in the number of accumulation sites between consecutive bone scintigraphy measurements, was inconsistent with the change in ESR, CRP, or VAS for pain.
•
The medications prescribed for SAPHO did not seem to contribute to a decrease in accumulation number.
•
Repeated bone scintigraphy did not seem to be useful for the assessment of disease activity in patients with SAPHO.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-019-04864-z</identifier><identifier>PMID: 31858336</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Acne ; Acquired Hyperostosis Syndrome - diagnostic imaging ; Acquired Hyperostosis Syndrome - metabolism ; Adult ; Biomarkers - metabolism ; Blood Sedimentation ; Bone and Bones - diagnostic imaging ; C-reactive protein ; C-Reactive Protein - metabolism ; Erythrocyte sedimentation rate ; Female ; Follow-Up Studies ; Humans ; Inflammation - metabolism ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Osteitis ; Pain ; Patients ; Pustulosis ; Radionuclide Imaging ; Retrospective Studies ; Rheumatology ; Scintigraphy ; Synovitis</subject><ispartof>Clinical rheumatology, 2020-04, Vol.39 (4), p.1305-1314</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2019</rights><rights>International League of Associations for Rheumatology (ILAR) 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4630bb687239a5aec122a5ec41e94ecece786848afdce68d935534550a11ff673</citedby><cites>FETCH-LOGICAL-c375t-4630bb687239a5aec122a5ec41e94ecece786848afdce68d935534550a11ff673</cites><orcidid>0000-0002-6309-7431</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-019-04864-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-019-04864-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31858336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Chen</creatorcontrib><creatorcontrib>Wang, Lun</creatorcontrib><creatorcontrib>Wu, Nan</creatorcontrib><creatorcontrib>Cao, Yihan</creatorcontrib><creatorcontrib>Sun, Xiaochuan</creatorcontrib><creatorcontrib>Zhang, Wen</creatorcontrib><creatorcontrib>Jing, Hongli</creatorcontrib><title>A retrospective study of bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: is it useful to repeat bone scintigraphy for disease assessment?</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Objectives
To investigate the value of repeated bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome and to characterize the changing pattern of osteoarticular lesions revealed by bone scintigraphy.
Method
Twenty-four patients with SAPHO syndrome who had repetitively undergone bone scintigraphy and tests of inflammatory markers (erythrocyte sedimentation rate (ESR) and/or C-reactive protein (CRP)) were included in this retrospective study. The change in accumulation number was recorded as the difference in the number of accumulation sites between consecutive bone scintigraphy. The visual analog scale (VAS) for pain and medications prescribed were also reviewed. The relationships of the change in accumulation number with medication prescribed and change in ESR or CRP were analyzed.
Results
Twenty-four and 23 patients had follow-up tests of ESR and CRP, from which 30 and 28 follow-up data were obtained, containing the corresponding changes in ESR and CRP, respectively. A decrease in total accumulation number observed by bone scintigraphy was rarely observed, while decreases in ESR, CRP, and VAS were predominant. The accumulation number had significantly increased over time (follow-up with ESR: r = 0.389,
p
= 0.034; follow-up with CRP: r = 0.438,
p
= 0.020), in accordance with an “imprinting” pattern, while the inflammatory markers and VAS for pain predominantly decreased. There was no significant association between the change in accumulation number (local/total) and the change in ESR or CRP values (
p
> 0.05) or medications used for SAPHO (
p
> 0.05).
Conclusions
This retrospective cohort study of 24 SAPHO patients demonstrated an “imprinting” pattern on bone scintigraphy, without a correlation to the decrease in inflammatory markers, patient disease assessment, or treatment type. Thus, repeated bone scintigraphy did not contribute an additional clinical value for the follow-up of patients with SAPHO.
Key Points
•
In a cohort of 24 SAPHO patients, repeated bone scintigraphy revealed a continuous increase in tracer accumulation number, indicating an “imprinting” pattern.
•
The change in tracer accumulation number, defined as the difference in the number of accumulation sites between consecutive bone scintigraphy measurements, was inconsistent with the change in ESR, CRP, or VAS for pain.
•
The medications prescribed for SAPHO did not seem to contribute to a decrease in accumulation number.
•
Repeated bone scintigraphy did not seem to be useful for the assessment of disease activity in patients with SAPHO.</description><subject>Acne</subject><subject>Acquired Hyperostosis Syndrome - diagnostic imaging</subject><subject>Acquired Hyperostosis Syndrome - metabolism</subject><subject>Adult</subject><subject>Biomarkers - metabolism</subject><subject>Blood Sedimentation</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Erythrocyte sedimentation rate</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Inflammation - metabolism</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Osteitis</subject><subject>Pain</subject><subject>Patients</subject><subject>Pustulosis</subject><subject>Radionuclide Imaging</subject><subject>Retrospective Studies</subject><subject>Rheumatology</subject><subject>Scintigraphy</subject><subject>Synovitis</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kV9r1jAUxoMo7nX6BbyQgDderJo0TZN4M8aYf2DgjV6XvO3p3ow2qTnpRvcl_UpL7VQQkUDCk_zOcw55CHnJ2VvOmHqHea9VwbgpWKXrqrh7RHa8ElVhTGUekx1TihWCG31EniFeM8ZKbfhTciS4llqIekd-nNEIKQacoE3uBiimuVto6Ok--Kxa55O7inY6LNR5mg5A-zAM4baYp5WabHLgE9Jblw4UFx9uXHJ4Qm3r4YROc_YbAq43h2WC3ChtyvqOZgErvdZ1MYzwnmbhEp0R-nmgKeThJrDpH8P0IdLOIVgEahEBccxznD4nT3o7ILx4OI_Jtw8XX88_FZdfPn4-P7ssWqFkKqpasP2-1qoUxkoLLS9LK6GtOJgK2ryUrnWlbd-1UOvOCClFJSWznPd9rcQxebP5TjF8nwFTMzpsYRishzBjU4rSKGFMyTL6-i_0OszR5-kypZWURjGZqXKj2vxHGKFvpuhGG5eGs2aNu9nibnLczc-4m7tc9OrBet6P0P0u-ZVvBsQGYH7yVxD_9P6P7T0EFbvc</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Li, Chen</creator><creator>Wang, Lun</creator><creator>Wu, Nan</creator><creator>Cao, Yihan</creator><creator>Sun, Xiaochuan</creator><creator>Zhang, Wen</creator><creator>Jing, Hongli</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6309-7431</orcidid></search><sort><creationdate>20200401</creationdate><title>A retrospective study of bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: is it useful to repeat bone scintigraphy for disease assessment?</title><author>Li, Chen ; Wang, Lun ; Wu, Nan ; Cao, Yihan ; Sun, Xiaochuan ; Zhang, Wen ; Jing, Hongli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4630bb687239a5aec122a5ec41e94ecece786848afdce68d935534550a11ff673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acne</topic><topic>Acquired Hyperostosis Syndrome - diagnostic imaging</topic><topic>Acquired Hyperostosis Syndrome - metabolism</topic><topic>Adult</topic><topic>Biomarkers - metabolism</topic><topic>Blood Sedimentation</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Erythrocyte sedimentation rate</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Inflammation - metabolism</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Osteitis</topic><topic>Pain</topic><topic>Patients</topic><topic>Pustulosis</topic><topic>Radionuclide Imaging</topic><topic>Retrospective Studies</topic><topic>Rheumatology</topic><topic>Scintigraphy</topic><topic>Synovitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Chen</creatorcontrib><creatorcontrib>Wang, Lun</creatorcontrib><creatorcontrib>Wu, Nan</creatorcontrib><creatorcontrib>Cao, Yihan</creatorcontrib><creatorcontrib>Sun, Xiaochuan</creatorcontrib><creatorcontrib>Zhang, Wen</creatorcontrib><creatorcontrib>Jing, Hongli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Chen</au><au>Wang, Lun</au><au>Wu, Nan</au><au>Cao, Yihan</au><au>Sun, Xiaochuan</au><au>Zhang, Wen</au><au>Jing, Hongli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A retrospective study of bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: is it useful to repeat bone scintigraphy for disease assessment?</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>39</volume><issue>4</issue><spage>1305</spage><epage>1314</epage><pages>1305-1314</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Objectives
To investigate the value of repeated bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome and to characterize the changing pattern of osteoarticular lesions revealed by bone scintigraphy.
Method
Twenty-four patients with SAPHO syndrome who had repetitively undergone bone scintigraphy and tests of inflammatory markers (erythrocyte sedimentation rate (ESR) and/or C-reactive protein (CRP)) were included in this retrospective study. The change in accumulation number was recorded as the difference in the number of accumulation sites between consecutive bone scintigraphy. The visual analog scale (VAS) for pain and medications prescribed were also reviewed. The relationships of the change in accumulation number with medication prescribed and change in ESR or CRP were analyzed.
Results
Twenty-four and 23 patients had follow-up tests of ESR and CRP, from which 30 and 28 follow-up data were obtained, containing the corresponding changes in ESR and CRP, respectively. A decrease in total accumulation number observed by bone scintigraphy was rarely observed, while decreases in ESR, CRP, and VAS were predominant. The accumulation number had significantly increased over time (follow-up with ESR: r = 0.389,
p
= 0.034; follow-up with CRP: r = 0.438,
p
= 0.020), in accordance with an “imprinting” pattern, while the inflammatory markers and VAS for pain predominantly decreased. There was no significant association between the change in accumulation number (local/total) and the change in ESR or CRP values (
p
> 0.05) or medications used for SAPHO (
p
> 0.05).
Conclusions
This retrospective cohort study of 24 SAPHO patients demonstrated an “imprinting” pattern on bone scintigraphy, without a correlation to the decrease in inflammatory markers, patient disease assessment, or treatment type. Thus, repeated bone scintigraphy did not contribute an additional clinical value for the follow-up of patients with SAPHO.
Key Points
•
In a cohort of 24 SAPHO patients, repeated bone scintigraphy revealed a continuous increase in tracer accumulation number, indicating an “imprinting” pattern.
•
The change in tracer accumulation number, defined as the difference in the number of accumulation sites between consecutive bone scintigraphy measurements, was inconsistent with the change in ESR, CRP, or VAS for pain.
•
The medications prescribed for SAPHO did not seem to contribute to a decrease in accumulation number.
•
Repeated bone scintigraphy did not seem to be useful for the assessment of disease activity in patients with SAPHO.</abstract><cop>London</cop><pub>Springer London</pub><pmid>31858336</pmid><doi>10.1007/s10067-019-04864-z</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6309-7431</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0770-3198 |
| ispartof | Clinical rheumatology, 2020-04, Vol.39 (4), p.1305-1314 |
| issn | 0770-3198 1434-9949 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2329739920 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acne Acquired Hyperostosis Syndrome - diagnostic imaging Acquired Hyperostosis Syndrome - metabolism Adult Biomarkers - metabolism Blood Sedimentation Bone and Bones - diagnostic imaging C-reactive protein C-Reactive Protein - metabolism Erythrocyte sedimentation rate Female Follow-Up Studies Humans Inflammation - metabolism Male Medicine Medicine & Public Health Middle Aged Original Article Osteitis Pain Patients Pustulosis Radionuclide Imaging Retrospective Studies Rheumatology Scintigraphy Synovitis |
| title | A retrospective study of bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: is it useful to repeat bone scintigraphy for disease assessment? |
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