Variable Thresholds of Vitamin D Plasma Levels to Suppress PTH: the Effect of Weight and Bariatric Surgery
Background Serum 25-hydroxyvitamin D [25(OH)D] and parathormone (PTH) have an inverse relation. The 25(OH)D threshold required to maximally suppress PTH has been used as a marker of optimal vitamin D status. Obesity is associated with lower serum levels of 25(OH)D and higher levels of PTH; however,...
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| Veröffentlicht in: | Obesity surgery 2020-04, Vol.30 (4), p.1551-1559 |
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| creator | Salazar, Daniela Alves Ferreira, Maria João Silva Neves, João Sérgio Pedro, Jorge Manuel Pires Guerreiro, Vanessa Alexandra e Silva Viana, Sara Mendonça, Fernando Silva, Maria Manuel Belo, Sandra Patrícia Sande, Ana Varela Freitas, Paula Carvalho, David Maurício |
| description | Background
Serum 25-hydroxyvitamin D [25(OH)D] and parathormone (PTH) have an inverse relation. The 25(OH)D threshold required to maximally suppress PTH has been used as a marker of optimal vitamin D status. Obesity is associated with lower serum levels of 25(OH)D and higher levels of PTH; however, the relation between these hormones in this setting is not well established. We aimed to assess the influence of excessive weight and weight loss after bariatric surgery on the relation between serum 25(OH)D and PTH.
Methods
Anthropometric and analytical parameters of phospho-calcium metabolism from 290 patients undergoing bariatric surgery were analyzed. The association between 25(OH)D and PTH before and 1 year after surgery was evaluated through Student’s
t
test and simple and multivariable linear regression.
Results
At baseline, there was an inverse association between 25(OH)D and PTH plasma levels (
β
= − 0.571;
p
= 0.001). The threshold for a significant increase of PTH at baseline was a 25(OH)D level of |
| doi_str_mv | 10.1007/s11695-019-04351-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2329739867</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2379354481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-8409a37d264ecfc129f692a5e404c0c0d11aa685cab25c2e932732f1bc067dc73</originalsourceid><addsrcrecordid>eNp9kctLAzEQxoMoWqv_gAcJePGymsfuJvGm9VGhYMGqx5BmZ9st-6jJrlD_elPrAzx4Gob5fd8M8yF0RMkZJUSce0pTlUSEqojEPKHR-xbqUUFkaJncRj2iUhJJxfge2vd-QQijKWO7aI9TmUiuWA8tno0rzLQEPJk78POmzDxucvxctKYqanyNx6XxlcEjeIPS47bBj91yGVCPx5PhBW7ngG_yHGy7lr1AMZu32NQZvlobt66wQeBm4FYHaCc3pYfDr9pHT7c3k8EwGj3c3Q8uR5HlImkjGRNluMhYGoPNLWUqTxUzCcQktsSSjFJjUplYM2WJZaA4E5zldGpJKjIreB-dbnyXrnntwLe6KryFsjQ1NJ3XjDMluJLpGj35gy6aztXhukAJxZM4ljRQbENZ13jvINdLV1TGrTQlep2E3iShQxL6Mwn9HkTHX9bdtILsR_L9-gDwDeDDqA4P-t39j-0HgeiTHQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2379354481</pqid></control><display><type>article</type><title>Variable Thresholds of Vitamin D Plasma Levels to Suppress PTH: the Effect of Weight and Bariatric Surgery</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Salazar, Daniela Alves ; Ferreira, Maria João Silva ; Neves, João Sérgio ; Pedro, Jorge Manuel Pires ; Guerreiro, Vanessa Alexandra ; e Silva Viana, Sara ; Mendonça, Fernando ; Silva, Maria Manuel ; Belo, Sandra Patrícia ; Sande, Ana Varela ; Freitas, Paula ; Carvalho, David Maurício</creator><creatorcontrib>Salazar, Daniela Alves ; Ferreira, Maria João Silva ; Neves, João Sérgio ; Pedro, Jorge Manuel Pires ; Guerreiro, Vanessa Alexandra ; e Silva Viana, Sara ; Mendonça, Fernando ; Silva, Maria Manuel ; Belo, Sandra Patrícia ; Sande, Ana Varela ; Freitas, Paula ; Carvalho, David Maurício</creatorcontrib><description>Background
Serum 25-hydroxyvitamin D [25(OH)D] and parathormone (PTH) have an inverse relation. The 25(OH)D threshold required to maximally suppress PTH has been used as a marker of optimal vitamin D status. Obesity is associated with lower serum levels of 25(OH)D and higher levels of PTH; however, the relation between these hormones in this setting is not well established. We aimed to assess the influence of excessive weight and weight loss after bariatric surgery on the relation between serum 25(OH)D and PTH.
Methods
Anthropometric and analytical parameters of phospho-calcium metabolism from 290 patients undergoing bariatric surgery were analyzed. The association between 25(OH)D and PTH before and 1 year after surgery was evaluated through Student’s
t
test and simple and multivariable linear regression.
Results
At baseline, there was an inverse association between 25(OH)D and PTH plasma levels (
β
= − 0.571;
p
= 0.001). The threshold for a significant increase of PTH at baseline was a 25(OH)D level of < 10 ng/mL (
p
< 0.001). At 1 year after surgery (
n
= 194), the association between the two variables was weaker (
β
= − 0.291;
p
= 0.014). The 25(OH)D threshold for a significant increase in serum PTH levels was lower in patients who maintained obesity (
n
= 77) [25(OH)D 5 vs 10 ng/mL].
Conclusions
PTH suppression threshold observed in patients with morbid obesity before and after bariatric surgery is lower than that described for the general population, suggesting that the 25(OH)D plasma levels may not be representative of the body’s vitamin D reserves. Other studies are required to demonstrate which optimal vitamin D levels need to be aimed for in obesity, in order to improve obese patients’ bone health.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-019-04351-z</identifier><identifier>PMID: 31858392</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bariatric Surgery ; Gastrointestinal surgery ; Humans ; Medicine ; Medicine & Public Health ; Obesity ; Obesity, Morbid - surgery ; Original Contributions ; Parathyroid Hormone ; Plasma ; Surgery ; Vitamin D ; Vitamin D Deficiency ; Weight control</subject><ispartof>Obesity surgery, 2020-04, Vol.30 (4), p.1551-1559</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Obesity Surgery is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-8409a37d264ecfc129f692a5e404c0c0d11aa685cab25c2e932732f1bc067dc73</citedby><cites>FETCH-LOGICAL-c375t-8409a37d264ecfc129f692a5e404c0c0d11aa685cab25c2e932732f1bc067dc73</cites><orcidid>0000-0002-1037-9689</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-019-04351-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-019-04351-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31858392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salazar, Daniela Alves</creatorcontrib><creatorcontrib>Ferreira, Maria João Silva</creatorcontrib><creatorcontrib>Neves, João Sérgio</creatorcontrib><creatorcontrib>Pedro, Jorge Manuel Pires</creatorcontrib><creatorcontrib>Guerreiro, Vanessa Alexandra</creatorcontrib><creatorcontrib>e Silva Viana, Sara</creatorcontrib><creatorcontrib>Mendonça, Fernando</creatorcontrib><creatorcontrib>Silva, Maria Manuel</creatorcontrib><creatorcontrib>Belo, Sandra Patrícia</creatorcontrib><creatorcontrib>Sande, Ana Varela</creatorcontrib><creatorcontrib>Freitas, Paula</creatorcontrib><creatorcontrib>Carvalho, David Maurício</creatorcontrib><title>Variable Thresholds of Vitamin D Plasma Levels to Suppress PTH: the Effect of Weight and Bariatric Surgery</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
Serum 25-hydroxyvitamin D [25(OH)D] and parathormone (PTH) have an inverse relation. The 25(OH)D threshold required to maximally suppress PTH has been used as a marker of optimal vitamin D status. Obesity is associated with lower serum levels of 25(OH)D and higher levels of PTH; however, the relation between these hormones in this setting is not well established. We aimed to assess the influence of excessive weight and weight loss after bariatric surgery on the relation between serum 25(OH)D and PTH.
Methods
Anthropometric and analytical parameters of phospho-calcium metabolism from 290 patients undergoing bariatric surgery were analyzed. The association between 25(OH)D and PTH before and 1 year after surgery was evaluated through Student’s
t
test and simple and multivariable linear regression.
Results
At baseline, there was an inverse association between 25(OH)D and PTH plasma levels (
β
= − 0.571;
p
= 0.001). The threshold for a significant increase of PTH at baseline was a 25(OH)D level of < 10 ng/mL (
p
< 0.001). At 1 year after surgery (
n
= 194), the association between the two variables was weaker (
β
= − 0.291;
p
= 0.014). The 25(OH)D threshold for a significant increase in serum PTH levels was lower in patients who maintained obesity (
n
= 77) [25(OH)D 5 vs 10 ng/mL].
Conclusions
PTH suppression threshold observed in patients with morbid obesity before and after bariatric surgery is lower than that described for the general population, suggesting that the 25(OH)D plasma levels may not be representative of the body’s vitamin D reserves. Other studies are required to demonstrate which optimal vitamin D levels need to be aimed for in obesity, in order to improve obese patients’ bone health.</description><subject>Bariatric Surgery</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Contributions</subject><subject>Parathyroid Hormone</subject><subject>Plasma</subject><subject>Surgery</subject><subject>Vitamin D</subject><subject>Vitamin D Deficiency</subject><subject>Weight control</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctLAzEQxoMoWqv_gAcJePGymsfuJvGm9VGhYMGqx5BmZ9st-6jJrlD_elPrAzx4Gob5fd8M8yF0RMkZJUSce0pTlUSEqojEPKHR-xbqUUFkaJncRj2iUhJJxfge2vd-QQijKWO7aI9TmUiuWA8tno0rzLQEPJk78POmzDxucvxctKYqanyNx6XxlcEjeIPS47bBj91yGVCPx5PhBW7ngG_yHGy7lr1AMZu32NQZvlobt66wQeBm4FYHaCc3pYfDr9pHT7c3k8EwGj3c3Q8uR5HlImkjGRNluMhYGoPNLWUqTxUzCcQktsSSjFJjUplYM2WJZaA4E5zldGpJKjIreB-dbnyXrnntwLe6KryFsjQ1NJ3XjDMluJLpGj35gy6aztXhukAJxZM4ljRQbENZ13jvINdLV1TGrTQlep2E3iShQxL6Mwn9HkTHX9bdtILsR_L9-gDwDeDDqA4P-t39j-0HgeiTHQ</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Salazar, Daniela Alves</creator><creator>Ferreira, Maria João Silva</creator><creator>Neves, João Sérgio</creator><creator>Pedro, Jorge Manuel Pires</creator><creator>Guerreiro, Vanessa Alexandra</creator><creator>e Silva Viana, Sara</creator><creator>Mendonça, Fernando</creator><creator>Silva, Maria Manuel</creator><creator>Belo, Sandra Patrícia</creator><creator>Sande, Ana Varela</creator><creator>Freitas, Paula</creator><creator>Carvalho, David Maurício</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1037-9689</orcidid></search><sort><creationdate>20200401</creationdate><title>Variable Thresholds of Vitamin D Plasma Levels to Suppress PTH: the Effect of Weight and Bariatric Surgery</title><author>Salazar, Daniela Alves ; Ferreira, Maria João Silva ; Neves, João Sérgio ; Pedro, Jorge Manuel Pires ; Guerreiro, Vanessa Alexandra ; e Silva Viana, Sara ; Mendonça, Fernando ; Silva, Maria Manuel ; Belo, Sandra Patrícia ; Sande, Ana Varela ; Freitas, Paula ; Carvalho, David Maurício</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-8409a37d264ecfc129f692a5e404c0c0d11aa685cab25c2e932732f1bc067dc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bariatric Surgery</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Contributions</topic><topic>Parathyroid Hormone</topic><topic>Plasma</topic><topic>Surgery</topic><topic>Vitamin D</topic><topic>Vitamin D Deficiency</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salazar, Daniela Alves</creatorcontrib><creatorcontrib>Ferreira, Maria João Silva</creatorcontrib><creatorcontrib>Neves, João Sérgio</creatorcontrib><creatorcontrib>Pedro, Jorge Manuel Pires</creatorcontrib><creatorcontrib>Guerreiro, Vanessa Alexandra</creatorcontrib><creatorcontrib>e Silva Viana, Sara</creatorcontrib><creatorcontrib>Mendonça, Fernando</creatorcontrib><creatorcontrib>Silva, Maria Manuel</creatorcontrib><creatorcontrib>Belo, Sandra Patrícia</creatorcontrib><creatorcontrib>Sande, Ana Varela</creatorcontrib><creatorcontrib>Freitas, Paula</creatorcontrib><creatorcontrib>Carvalho, David Maurício</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salazar, Daniela Alves</au><au>Ferreira, Maria João Silva</au><au>Neves, João Sérgio</au><au>Pedro, Jorge Manuel Pires</au><au>Guerreiro, Vanessa Alexandra</au><au>e Silva Viana, Sara</au><au>Mendonça, Fernando</au><au>Silva, Maria Manuel</au><au>Belo, Sandra Patrícia</au><au>Sande, Ana Varela</au><au>Freitas, Paula</au><au>Carvalho, David Maurício</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variable Thresholds of Vitamin D Plasma Levels to Suppress PTH: the Effect of Weight and Bariatric Surgery</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>30</volume><issue>4</issue><spage>1551</spage><epage>1559</epage><pages>1551-1559</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
Serum 25-hydroxyvitamin D [25(OH)D] and parathormone (PTH) have an inverse relation. The 25(OH)D threshold required to maximally suppress PTH has been used as a marker of optimal vitamin D status. Obesity is associated with lower serum levels of 25(OH)D and higher levels of PTH; however, the relation between these hormones in this setting is not well established. We aimed to assess the influence of excessive weight and weight loss after bariatric surgery on the relation between serum 25(OH)D and PTH.
Methods
Anthropometric and analytical parameters of phospho-calcium metabolism from 290 patients undergoing bariatric surgery were analyzed. The association between 25(OH)D and PTH before and 1 year after surgery was evaluated through Student’s
t
test and simple and multivariable linear regression.
Results
At baseline, there was an inverse association between 25(OH)D and PTH plasma levels (
β
= − 0.571;
p
= 0.001). The threshold for a significant increase of PTH at baseline was a 25(OH)D level of < 10 ng/mL (
p
< 0.001). At 1 year after surgery (
n
= 194), the association between the two variables was weaker (
β
= − 0.291;
p
= 0.014). The 25(OH)D threshold for a significant increase in serum PTH levels was lower in patients who maintained obesity (
n
= 77) [25(OH)D 5 vs 10 ng/mL].
Conclusions
PTH suppression threshold observed in patients with morbid obesity before and after bariatric surgery is lower than that described for the general population, suggesting that the 25(OH)D plasma levels may not be representative of the body’s vitamin D reserves. Other studies are required to demonstrate which optimal vitamin D levels need to be aimed for in obesity, in order to improve obese patients’ bone health.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31858392</pmid><doi>10.1007/s11695-019-04351-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1037-9689</orcidid></addata></record> |
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| ispartof | Obesity surgery, 2020-04, Vol.30 (4), p.1551-1559 |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Bariatric Surgery Gastrointestinal surgery Humans Medicine Medicine & Public Health Obesity Obesity, Morbid - surgery Original Contributions Parathyroid Hormone Plasma Surgery Vitamin D Vitamin D Deficiency Weight control |
| title | Variable Thresholds of Vitamin D Plasma Levels to Suppress PTH: the Effect of Weight and Bariatric Surgery |
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