Relationship between herpesviruses and periodontal disease progression
Aim To investigate the role of Epstein–Barr virus (EBV), cytomegalovirus (CMV), and anaerobic bacteria in the progression of periodontitis. Methods Eighty‐one adults with generalized moderate to severe periodontitis were randomly assigned to: oral hygiene or scaling and root planning ± placebo or po...
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| Veröffentlicht in: | Journal of clinical periodontology 2020-04, Vol.47 (4), p.442-450 |
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| container_title | Journal of clinical periodontology |
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| creator | Emecen‐Huja, Pinar Danaher, Robert J. Dawson, Dolphus R. Wang, Chunmei Kryscio, Richard J. Ebersole, Jeffrey L. Miller, Craig S. |
| description | Aim
To investigate the role of Epstein–Barr virus (EBV), cytomegalovirus (CMV), and anaerobic bacteria in the progression of periodontitis.
Methods
Eighty‐one adults with generalized moderate to severe periodontitis were randomly assigned to: oral hygiene or scaling and root planning ± placebo or polyunsaturated fatty acids fish oil. Subgingival plaque samples collected from three healthy and three disease sites at weeks 0, 16, and 28 and from sites demonstrating disease progression were analysed for EBV, CMV, P. gingivalis (Pg), T. forsythia (Tf), and T. denticola (Td) DNA using quantitative polymerase chain reaction.
Results
Cytomegalovirus was detected in 0.3% (4/1454) sites. EBV was present in 12.2% of healthy sites (89/728) and 27.6% disease sites (201/726; p |
| doi_str_mv | 10.1111/jcpe.13239 |
| format | Article |
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To investigate the role of Epstein–Barr virus (EBV), cytomegalovirus (CMV), and anaerobic bacteria in the progression of periodontitis.
Methods
Eighty‐one adults with generalized moderate to severe periodontitis were randomly assigned to: oral hygiene or scaling and root planning ± placebo or polyunsaturated fatty acids fish oil. Subgingival plaque samples collected from three healthy and three disease sites at weeks 0, 16, and 28 and from sites demonstrating disease progression were analysed for EBV, CMV, P. gingivalis (Pg), T. forsythia (Tf), and T. denticola (Td) DNA using quantitative polymerase chain reaction.
Results
Cytomegalovirus was detected in 0.3% (4/1454) sites. EBV was present in 12.2% of healthy sites (89/728) and 27.6% disease sites (201/726; p < .0001), but was in low copy number. Disease progression occurred in 28.4% of participants (23/81) and developed predominantly at sites identified as diseased (75/78; 96.2%). CMV and EBV were not associated with disease progression (p = .13) regardless of treatment. In contrast, disease sites were associated with higher levels of Pg, Td, Tf, and total bacteria, and sites that exhibited disease progression were associated with an abundance of Td and Tf (p < .04).
Conclusion
Disease progression was associated with Gram‐negative anaerobic bacteria; not EBV or CMV.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.13239</identifier><identifier>PMID: 31860742</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Anaerobic bacteria ; Bacteria ; Copy number ; Cytomegalovirus ; Disease Progression ; Epstein-Barr virus ; Epstein–Barr virus infections ; Fish oils ; Gum disease ; Herpesviridae ; Herpesvirus 4, Human ; Humans ; Oral hygiene ; Periodontal diseases ; Periodontitis ; Polymerase chain reaction ; Polyunsaturated fatty acids</subject><ispartof>Journal of clinical periodontology, 2020-04, Vol.47 (4), p.442-450</ispartof><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4489-549035e9a777750d574455fb253e7f9194292d579963ad213380b1e4b1261f0d3</citedby><cites>FETCH-LOGICAL-c4489-549035e9a777750d574455fb253e7f9194292d579963ad213380b1e4b1261f0d3</cites><orcidid>0000-0002-7657-4604 ; 0000-0002-9743-6585</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpe.13239$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpe.13239$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,777,781,882,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31860742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Emecen‐Huja, Pinar</creatorcontrib><creatorcontrib>Danaher, Robert J.</creatorcontrib><creatorcontrib>Dawson, Dolphus R.</creatorcontrib><creatorcontrib>Wang, Chunmei</creatorcontrib><creatorcontrib>Kryscio, Richard J.</creatorcontrib><creatorcontrib>Ebersole, Jeffrey L.</creatorcontrib><creatorcontrib>Miller, Craig S.</creatorcontrib><title>Relationship between herpesviruses and periodontal disease progression</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Aim
To investigate the role of Epstein–Barr virus (EBV), cytomegalovirus (CMV), and anaerobic bacteria in the progression of periodontitis.
Methods
Eighty‐one adults with generalized moderate to severe periodontitis were randomly assigned to: oral hygiene or scaling and root planning ± placebo or polyunsaturated fatty acids fish oil. Subgingival plaque samples collected from three healthy and three disease sites at weeks 0, 16, and 28 and from sites demonstrating disease progression were analysed for EBV, CMV, P. gingivalis (Pg), T. forsythia (Tf), and T. denticola (Td) DNA using quantitative polymerase chain reaction.
Results
Cytomegalovirus was detected in 0.3% (4/1454) sites. EBV was present in 12.2% of healthy sites (89/728) and 27.6% disease sites (201/726; p < .0001), but was in low copy number. Disease progression occurred in 28.4% of participants (23/81) and developed predominantly at sites identified as diseased (75/78; 96.2%). CMV and EBV were not associated with disease progression (p = .13) regardless of treatment. In contrast, disease sites were associated with higher levels of Pg, Td, Tf, and total bacteria, and sites that exhibited disease progression were associated with an abundance of Td and Tf (p < .04).
Conclusion
Disease progression was associated with Gram‐negative anaerobic bacteria; not EBV or CMV.</description><subject>Adult</subject><subject>Anaerobic bacteria</subject><subject>Bacteria</subject><subject>Copy number</subject><subject>Cytomegalovirus</subject><subject>Disease Progression</subject><subject>Epstein-Barr virus</subject><subject>Epstein–Barr virus infections</subject><subject>Fish oils</subject><subject>Gum disease</subject><subject>Herpesviridae</subject><subject>Herpesvirus 4, Human</subject><subject>Humans</subject><subject>Oral hygiene</subject><subject>Periodontal diseases</subject><subject>Periodontitis</subject><subject>Polymerase chain reaction</subject><subject>Polyunsaturated fatty acids</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFK7DAUhoMoOlfd-ABScCMXqjlJ0zQbQQa9KoIiCu5C2p46GTpNTVrFtzfeUVEXnk0g-fLxH35CdoAeQJzDedXjAXDG1QqZQE5pSgXcr5IJ5ZSnuZJqg_wJYU4pSM75OtngUORUZmxCTm-wNYN1XZjZPilxeEbskhn6HsOT9WPAkJiuTnr01tWuG0yb1DagCZj03j14DCH-3iJrjWkDbr-fm-Tu9OR2epZeXv07nx5fplWWFSoVmaJcoDIyjqC1kFkmRFMywVE2ClTGFIu3SuXc1Aw4L2gJmJXAcmhozTfJ0dLbj-UC6wq7wZtW994ujH_Rzlj9_aWzM_3gnrSkKmdSRsH-u8C7xxHDoBc2VNi2pkM3Bs04U5IXACqiez_QuRt9F9eLVAGFiCHzSP1dUpV3IXhsPsMA1W_16Ld69P96Irz7Nf4n-tFHBGAJPNsWX35R6Yvp9clS-gonj5p5</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Emecen‐Huja, Pinar</creator><creator>Danaher, Robert J.</creator><creator>Dawson, Dolphus R.</creator><creator>Wang, Chunmei</creator><creator>Kryscio, Richard J.</creator><creator>Ebersole, Jeffrey L.</creator><creator>Miller, Craig S.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7657-4604</orcidid><orcidid>https://orcid.org/0000-0002-9743-6585</orcidid></search><sort><creationdate>202004</creationdate><title>Relationship between herpesviruses and periodontal disease progression</title><author>Emecen‐Huja, Pinar ; Danaher, Robert J. ; Dawson, Dolphus R. ; Wang, Chunmei ; Kryscio, Richard J. ; Ebersole, Jeffrey L. ; Miller, Craig S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4489-549035e9a777750d574455fb253e7f9194292d579963ad213380b1e4b1261f0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Anaerobic bacteria</topic><topic>Bacteria</topic><topic>Copy number</topic><topic>Cytomegalovirus</topic><topic>Disease Progression</topic><topic>Epstein-Barr virus</topic><topic>Epstein–Barr virus infections</topic><topic>Fish oils</topic><topic>Gum disease</topic><topic>Herpesviridae</topic><topic>Herpesvirus 4, Human</topic><topic>Humans</topic><topic>Oral hygiene</topic><topic>Periodontal diseases</topic><topic>Periodontitis</topic><topic>Polymerase chain reaction</topic><topic>Polyunsaturated fatty acids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Emecen‐Huja, Pinar</creatorcontrib><creatorcontrib>Danaher, Robert J.</creatorcontrib><creatorcontrib>Dawson, Dolphus R.</creatorcontrib><creatorcontrib>Wang, Chunmei</creatorcontrib><creatorcontrib>Kryscio, Richard J.</creatorcontrib><creatorcontrib>Ebersole, Jeffrey L.</creatorcontrib><creatorcontrib>Miller, Craig S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Emecen‐Huja, Pinar</au><au>Danaher, Robert J.</au><au>Dawson, Dolphus R.</au><au>Wang, Chunmei</au><au>Kryscio, Richard J.</au><au>Ebersole, Jeffrey L.</au><au>Miller, Craig S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between herpesviruses and periodontal disease progression</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2020-04</date><risdate>2020</risdate><volume>47</volume><issue>4</issue><spage>442</spage><epage>450</epage><pages>442-450</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Aim
To investigate the role of Epstein–Barr virus (EBV), cytomegalovirus (CMV), and anaerobic bacteria in the progression of periodontitis.
Methods
Eighty‐one adults with generalized moderate to severe periodontitis were randomly assigned to: oral hygiene or scaling and root planning ± placebo or polyunsaturated fatty acids fish oil. Subgingival plaque samples collected from three healthy and three disease sites at weeks 0, 16, and 28 and from sites demonstrating disease progression were analysed for EBV, CMV, P. gingivalis (Pg), T. forsythia (Tf), and T. denticola (Td) DNA using quantitative polymerase chain reaction.
Results
Cytomegalovirus was detected in 0.3% (4/1454) sites. EBV was present in 12.2% of healthy sites (89/728) and 27.6% disease sites (201/726; p < .0001), but was in low copy number. Disease progression occurred in 28.4% of participants (23/81) and developed predominantly at sites identified as diseased (75/78; 96.2%). CMV and EBV were not associated with disease progression (p = .13) regardless of treatment. In contrast, disease sites were associated with higher levels of Pg, Td, Tf, and total bacteria, and sites that exhibited disease progression were associated with an abundance of Td and Tf (p < .04).
Conclusion
Disease progression was associated with Gram‐negative anaerobic bacteria; not EBV or CMV.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>31860742</pmid><doi>10.1111/jcpe.13239</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7657-4604</orcidid><orcidid>https://orcid.org/0000-0002-9743-6585</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anaerobic bacteria Bacteria Copy number Cytomegalovirus Disease Progression Epstein-Barr virus Epstein–Barr virus infections Fish oils Gum disease Herpesviridae Herpesvirus 4, Human Humans Oral hygiene Periodontal diseases Periodontitis Polymerase chain reaction Polyunsaturated fatty acids |
| title | Relationship between herpesviruses and periodontal disease progression |
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