Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target

Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain activated sphingolipid-metabolizing enzymes, including sphingosine kinase 1 (SphK1) and SphK2, that generate sphingosine-...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 2020-03, Vol.207, p.107464-107464, Article 107464
Hauptverfasser:	Sukocheva, Olga A., Furuya, Hideki, Ng, Mei Li, Friedemann, Markus, Menschikowski, Mario, Tarasov, Vadim V., Chubarev, Vladimir N., Klochkov, Sergey G., Neganova, Margarita E., Mangoni, Arduino A., Aliev, Gjumrakch, Bishayee, Anupam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colitis Colon cancer Esophageal cancer Fingolimod Gastric cancer Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - metabolism Humans Inflammation - drug therapy Inflammation - metabolism Inflammatory bowel disease Microbiome Neoplasms - drug therapy Neoplasms - metabolism Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Phosphotransferases (Alcohol Group Acceptor) - metabolism Signal Transduction Sphingolipids - metabolism Sphingosine kinase Sphingosine-1-phosphate Sphingosine-1-phosphate receptor Sphingosine-1-Phosphate Receptors - antagonists & inhibitors Sphingosine-1-Phosphate Receptors - metabolism
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