Accelerated Blood Clearance of Nanoemulsions Modified with PEG-Cholesterol and PEG-Phospholipid Derivatives in Rats: The Effect of PEG-Lipid Linkages and PEG Molecular Weights

Various types of nanocarriers modified with poly­(ethylene glycol) (PEG) exhibit the accelerated blood clearance (ABC) phenomenon, resulting in reduced circulation time and abnormal increase in hepatic and splenic accumulations. Based on the abundance of esterases in the serum of rats, we developed...

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Veröffentlicht in:	Molecular pharmaceutics 2020-04, Vol.17 (4), p.1059-1070
Hauptverfasser:	Liu, Mengyang, Chu, Yanyi, Liu, Huan, Su, Yuqing, Zhang, Qi, Jiao, Jiao, Liu, Mingqi, Ding, Junqiang, Liu, Min, Hu, Yawei, Dai, Yueying, Zhang, Rongping, Liu, Xinrong, Deng, Yihui, Song, Yanzhi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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