Organogels based on amino acid derivatives and their optimization for drug release using response surface methodology
Organogels are excellent drug carrier for controlled release. Organogels based on amino acid derivatives has been widely used in the area of drug delivery. In this study, a series of the organogel system based on amino acid derivatives gelators was designed and prepared to investigate the structure-...
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| Veröffentlicht in: | Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2020-01, Vol.48 (1), p.266-275 |
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| container_title | Artificial cells, nanomedicine, and biotechnology |
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| creator | Hu, Beibei Yan, Haipeng Sun, Yanping Chen, Xi Sun, Yujuan Li, Sanming Jing, Yongshuai Li, Heran |
| description | Organogels are excellent drug carrier for controlled release. Organogels based on amino acid derivatives has been widely used in the area of drug delivery. In this study, a series of the organogel system based on amino acid derivatives gelators was designed and prepared to investigate the structure-property correlation in organogels. To investigate the factors that influence the property of drug release, we varied the formulation in the organogels: gelator structure, gelator concentration, volume of antigelation solvent, and drug loading. Through the Box-Behnken tests, the optimum organogel formulation in vitro was obtained. The self-healing properties of the organogel have been utilised for injection of a model lipophilic risperidone in situ, and sustained release of the drug has been studied over about one week in vivo. In conclusion, the gelation ability of gelators could be adjusted by the gelator structure. Gel property is related with the whole composition of the formulation. As drug carrier, the drug release property of organogels is affected by multiple factors. Our investigation of the gel release property will play a theoretical guiding role in the application in the in situ drug delivery system. |
| doi_str_mv | 10.1080/21691401.2019.1699833 |
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Organogels based on amino acid derivatives has been widely used in the area of drug delivery. In this study, a series of the organogel system based on amino acid derivatives gelators was designed and prepared to investigate the structure-property correlation in organogels. To investigate the factors that influence the property of drug release, we varied the formulation in the organogels: gelator structure, gelator concentration, volume of antigelation solvent, and drug loading. Through the Box-Behnken tests, the optimum organogel formulation in vitro was obtained. The self-healing properties of the organogel have been utilised for injection of a model lipophilic risperidone in situ, and sustained release of the drug has been studied over about one week in vivo. In conclusion, the gelation ability of gelators could be adjusted by the gelator structure. Gel property is related with the whole composition of the formulation. As drug carrier, the drug release property of organogels is affected by multiple factors. Our investigation of the gel release property will play a theoretical guiding role in the application in the in situ drug delivery system.</description><identifier>ISSN: 2169-1401</identifier><identifier>EISSN: 2169-141X</identifier><identifier>DOI: 10.1080/21691401.2019.1699833</identifier><identifier>PMID: 31851842</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Amino acid derivatives ; Amino acids ; Box-Behnken design ; burst release ; Controlled release ; Derivatives ; Drug carriers ; Drug delivery ; Drug delivery systems ; in situ organogel ; In vivo methods and tests ; Investigations ; in vivo release ; Lipophilic ; Optimization ; Response surface methodology ; Risperidone ; Sustained release</subject><ispartof>Artificial cells, nanomedicine, and biotechnology, 2020-01, Vol.48 (1), p.266-275</ispartof><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group 2019</rights><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-d104b06bff2ca783572e131c4668a2843c04c1a5b0ba5a4ba1970ea701800a013</citedby><cites>FETCH-LOGICAL-c507t-d104b06bff2ca783572e131c4668a2843c04c1a5b0ba5a4ba1970ea701800a013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/21691401.2019.1699833$$EPDF$$P50$$Ginformaworld$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/21691401.2019.1699833$$EHTML$$P50$$Ginformaworld$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,2096,27479,27901,27902,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31851842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Beibei</creatorcontrib><creatorcontrib>Yan, Haipeng</creatorcontrib><creatorcontrib>Sun, Yanping</creatorcontrib><creatorcontrib>Chen, Xi</creatorcontrib><creatorcontrib>Sun, Yujuan</creatorcontrib><creatorcontrib>Li, Sanming</creatorcontrib><creatorcontrib>Jing, Yongshuai</creatorcontrib><creatorcontrib>Li, Heran</creatorcontrib><title>Organogels based on amino acid derivatives and their optimization for drug release using response surface methodology</title><title>Artificial cells, nanomedicine, and biotechnology</title><addtitle>Artif Cells Nanomed Biotechnol</addtitle><description>Organogels are excellent drug carrier for controlled release. Organogels based on amino acid derivatives has been widely used in the area of drug delivery. In this study, a series of the organogel system based on amino acid derivatives gelators was designed and prepared to investigate the structure-property correlation in organogels. To investigate the factors that influence the property of drug release, we varied the formulation in the organogels: gelator structure, gelator concentration, volume of antigelation solvent, and drug loading. Through the Box-Behnken tests, the optimum organogel formulation in vitro was obtained. The self-healing properties of the organogel have been utilised for injection of a model lipophilic risperidone in situ, and sustained release of the drug has been studied over about one week in vivo. In conclusion, the gelation ability of gelators could be adjusted by the gelator structure. Gel property is related with the whole composition of the formulation. As drug carrier, the drug release property of organogels is affected by multiple factors. Our investigation of the gel release property will play a theoretical guiding role in the application in the in situ drug delivery system.</description><subject>Amino acid derivatives</subject><subject>Amino acids</subject><subject>Box-Behnken design</subject><subject>burst release</subject><subject>Controlled release</subject><subject>Derivatives</subject><subject>Drug carriers</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>in situ organogel</subject><subject>In vivo methods and tests</subject><subject>Investigations</subject><subject>in vivo release</subject><subject>Lipophilic</subject><subject>Optimization</subject><subject>Response surface methodology</subject><subject>Risperidone</subject><subject>Sustained release</subject><issn>2169-1401</issn><issn>2169-141X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>DOA</sourceid><recordid>eNp9kU9v1DAQxSMEolXpRwBZ4sJlF49jx84NVPGnUqVeQOJmTZxJ6lUSL3ZStHx6HHa7Bw74Yr_Rb96M9YriNfAtcMPfC6hqkBy2gkO9zaI2ZfmsuFzrG5Dw4_n5zeGiuE5px_MxUGklXxYXJRgFRorLYrmPPU6hpyGxBhO1LEwMRz8Fhs63rKXoH3H2j5QYTi2bH8hHFvazH_3vXM90FyJr49KzSANlC7YkP60q7cOUZVpih47YSPNDaMMQ-sOr4kWHQ6Lr031VfP_86dvN183d_Zfbm493G6e4njctcNnwquk64VCbUmlBUIKTVWVQGFk6Lh2ganiDCmWDUGtOqDkYzpFDeVXcHn3bgDu7j37EeLABvf1bCLG3GGfvBrKmangpSyM64jJPbbRy1Ekh8zhNavV6d_Tax_BzoTTb0SdHw4AThSVZUQqjtdS1zOjbf9BdWOKUf2qF1JUBJZXIlDpSLoaUInXnBYHbNWb7FLNdY7anmHPfm5P70ozUnrueQs3AhyPgp5zNiL9CHFo742EIsYs4OZ8y_N8ZfwDQ9LZN</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Hu, Beibei</creator><creator>Yan, Haipeng</creator><creator>Sun, Yanping</creator><creator>Chen, Xi</creator><creator>Sun, Yujuan</creator><creator>Li, Sanming</creator><creator>Jing, Yongshuai</creator><creator>Li, Heran</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20200101</creationdate><title>Organogels based on amino acid derivatives and their optimization for drug release using response surface methodology</title><author>Hu, Beibei ; Yan, Haipeng ; Sun, Yanping ; Chen, Xi ; Sun, Yujuan ; Li, Sanming ; Jing, Yongshuai ; Li, Heran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-d104b06bff2ca783572e131c4668a2843c04c1a5b0ba5a4ba1970ea701800a013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amino acid derivatives</topic><topic>Amino acids</topic><topic>Box-Behnken design</topic><topic>burst release</topic><topic>Controlled release</topic><topic>Derivatives</topic><topic>Drug carriers</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>in situ organogel</topic><topic>In vivo methods and tests</topic><topic>Investigations</topic><topic>in vivo release</topic><topic>Lipophilic</topic><topic>Optimization</topic><topic>Response surface methodology</topic><topic>Risperidone</topic><topic>Sustained release</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Beibei</creatorcontrib><creatorcontrib>Yan, Haipeng</creatorcontrib><creatorcontrib>Sun, Yanping</creatorcontrib><creatorcontrib>Chen, Xi</creatorcontrib><creatorcontrib>Sun, Yujuan</creatorcontrib><creatorcontrib>Li, Sanming</creatorcontrib><creatorcontrib>Jing, Yongshuai</creatorcontrib><creatorcontrib>Li, Heran</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Beibei</au><au>Yan, Haipeng</au><au>Sun, Yanping</au><au>Chen, Xi</au><au>Sun, Yujuan</au><au>Li, Sanming</au><au>Jing, Yongshuai</au><au>Li, Heran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Organogels based on amino acid derivatives and their optimization for drug release using response surface methodology</atitle><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle><addtitle>Artif Cells Nanomed Biotechnol</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>48</volume><issue>1</issue><spage>266</spage><epage>275</epage><pages>266-275</pages><issn>2169-1401</issn><eissn>2169-141X</eissn><abstract>Organogels are excellent drug carrier for controlled release. Organogels based on amino acid derivatives has been widely used in the area of drug delivery. In this study, a series of the organogel system based on amino acid derivatives gelators was designed and prepared to investigate the structure-property correlation in organogels. To investigate the factors that influence the property of drug release, we varied the formulation in the organogels: gelator structure, gelator concentration, volume of antigelation solvent, and drug loading. Through the Box-Behnken tests, the optimum organogel formulation in vitro was obtained. The self-healing properties of the organogel have been utilised for injection of a model lipophilic risperidone in situ, and sustained release of the drug has been studied over about one week in vivo. In conclusion, the gelation ability of gelators could be adjusted by the gelator structure. Gel property is related with the whole composition of the formulation. As drug carrier, the drug release property of organogels is affected by multiple factors. Our investigation of the gel release property will play a theoretical guiding role in the application in the in situ drug delivery system.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>31851842</pmid><doi>10.1080/21691401.2019.1699833</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino acid derivatives Amino acids Box-Behnken design burst release Controlled release Derivatives Drug carriers Drug delivery Drug delivery systems in situ organogel In vivo methods and tests Investigations in vivo release Lipophilic Optimization Response surface methodology Risperidone Sustained release |
| title | Organogels based on amino acid derivatives and their optimization for drug release using response surface methodology |
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