Global ubiquitome analysis of substantia nigra in doubly-mutant human alpha-synuclein transgenic mice

•A transgenic mouse model expressing doubly-mutant human alpha-synuclein was used.•Globally ubiquitinated proteins in SNpc of pre-symptomatic PD were identified.•Endocytosis pathway was likely regulated by ubiquitination in early-stage PD. Progression through neuronal loss of substantia nigra pars c...

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