Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography
Objective To implement detailed EU cardiac computed tomography angiography (CCTA) quality criteria in the multicentre DISCHARGE trial (FP72007-2013, EC-GA 603266), we reviewed image quality and adherence to CCTA protocol and to the recommendations of invasive coronary angiography (ICA) in a pilot st...
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| Veröffentlicht in: | European radiology 2020-04, Vol.30 (4), p.1997-2009 |
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| creator | De Rubeis, Gianluca Napp, Adriane E. Schlattmann, Peter Geleijns, Jacob Laule, Michael Dreger, Henryk Kofoed, Klaus Sørgaard, Mathias Engstrøm, Thomas Tilsted, Hans Henrik Boi, Alberto Porcu, Michele Cossa, Stefano Rodríguez-Palomares, José F. Xavier Valente, Filipa Roque, Albert Feuchtner, Gudrun Plank, Fabian Štěchovský, Cyril Adla, Theodor Schroeder, Stephen Zelesny, Thomas Gutberlet, Matthias Woinke, Michael Károlyi, Mihály Karády, Júlia Donnelly, Patrick Ball, Peter Dodd, Jonathan Hensey, Mark Mancone, Massimo Ceccacci, Andrea Berzina, Marina Zvaigzne, Ligita Sakalyte, Gintare Basevičius, Algidas Ilnicka-Suckiel, Małgorzata Kuśmierz, Donata Faria, Rita Gama-Ribeiro, Vasco Benedek, Imre Benedek, Teodora Adjić, Filip Čanković, Milenko Berry, Colin Delles, Christian Thwaite, Erica Davis, Gershan Knuuti, Juhani Pietilä, Mikko Kepka, Cezary Kruk, Mariusz Vidakovic, Radosav Neskovic, Aleksandar N. Lecumberri, Iñigo Diez Gonzales, Ignacio Ruzsics, Balazs Fisher, Mike Dewey, Marc Francone, Marco |
| description | Objective
To implement detailed EU cardiac computed tomography angiography (CCTA) quality criteria in the multicentre DISCHARGE trial (FP72007-2013, EC-GA 603266), we reviewed image quality and adherence to CCTA protocol and to the recommendations of invasive coronary angiography (ICA) in a pilot study.
Materials and methods
From every clinical centre, imaging datasets of three patients per arm were assessed for adherence to the inclusion/exclusion criteria of the pilot study, predefined standards for the CCTA protocol and ICA recommendations, image quality and non-diagnostic (NDX) rate. These parameters were compared via multinomial regression and ANOVA. If a site did not reach the minimum quality level, additional datasets had to be sent before entering into the final accepted database (FADB).
Results
We analysed 226 cases (150 CCTA/76 ICA). The inclusion/exclusion criteria were not met by 6 of the 226 (2.7%) datasets. The predefined standard was not met by 13 of 76 ICA datasets (17.1%). This percentage decreased between the initial CCTA database and the FADB (multinomial regression, 53 of 70 vs 17 of 75 [76%] vs [23%]). The signal-to-noise ratio and contrast-to-noise ratio of the FADB did not improve significantly (ANOVA,
p
= 0.20;
p
= 0.09). The CTA NDX rate was reduced, but not significantly (initial CCTA database 15 of 70 [21.4%]) and FADB 9 of 75 [12%];
p
= 0.13).
Conclusion
We were able to increase conformity to the inclusion/exclusion criteria and CCTA protocol, improve image quality and decrease the CCTA NDX rate by implementing EU CCTA quality criteria and ICA recommendations.
Key Points
•
Failure to meet protocol adherence in cardiac CTA was high in the pilot study (77.6%).
•
Image quality varies between sites and can be improved by feedback given by the core lab.
•
Conformance with new EU cardiac CT quality criteria might render cardiac CTA findings more consistent and comparable. |
| doi_str_mv | 10.1007/s00330-019-06522-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2327937050</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2375371275</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-c3bbf88bf9ae6b2118cfefb98ec3e10fccb86a8a69e55c648c6d962ede50fddd3</originalsourceid><addsrcrecordid>eNp9kctu1DAYRi1ERacDL8ACWWLDJtSXXGx21bS0lSq1grKOHPv3jKskntpOpel78L54mgEkFmxsyT7f8eVD6D0lnykhzWkkhHNSECoLUleMFc-v0IKWnBWUiPI1WhDJRdFIWR6jkxgfCCGSls0bdMypKEtZiQX6eed6n3BMk9lhb3HaAB6mPjkNYwqAz6-_r67Ovl1e4PvgVP8Fu0GtAT9Oqndph9Vo8Db45LXvsTIbCDBqwAFidsS9UPthOyUwOPnBr4PabuaUG59UdE-QgeBHFfara3cg3qIjq_oI7w7zEv34enG_uipubi-vV2c3hS6pTIXmXWeF6KxUUHeMUqEt2E4K0BwosVp3olZC1RKqStel0LWRNQMDFbHGGL5En2ZvfsPjBDG1g4sa-l6N4KfYMs4ayRtSkYx-_Ad98FMY8-0y1VS8oSyPS8RmSgcfYwDbbkP-sbBrKWn3pbVzaW0urX0prX3OoQ8H9dQNYP5EfreUAT4DMW-Nawh_z_6P9he4J6be</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2375371275</pqid></control><display><type>article</type><title>Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>De Rubeis, Gianluca ; Napp, Adriane E. ; Schlattmann, Peter ; Geleijns, Jacob ; Laule, Michael ; Dreger, Henryk ; Kofoed, Klaus ; Sørgaard, Mathias ; Engstrøm, Thomas ; Tilsted, Hans Henrik ; Boi, Alberto ; Porcu, Michele ; Cossa, Stefano ; Rodríguez-Palomares, José F. ; Xavier Valente, Filipa ; Roque, Albert ; Feuchtner, Gudrun ; Plank, Fabian ; Štěchovský, Cyril ; Adla, Theodor ; Schroeder, Stephen ; Zelesny, Thomas ; Gutberlet, Matthias ; Woinke, Michael ; Károlyi, Mihály ; Karády, Júlia ; Donnelly, Patrick ; Ball, Peter ; Dodd, Jonathan ; Hensey, Mark ; Mancone, Massimo ; Ceccacci, Andrea ; Berzina, Marina ; Zvaigzne, Ligita ; Sakalyte, Gintare ; Basevičius, Algidas ; Ilnicka-Suckiel, Małgorzata ; Kuśmierz, Donata ; Faria, Rita ; Gama-Ribeiro, Vasco ; Benedek, Imre ; Benedek, Teodora ; Adjić, Filip ; Čanković, Milenko ; Berry, Colin ; Delles, Christian ; Thwaite, Erica ; Davis, Gershan ; Knuuti, Juhani ; Pietilä, Mikko ; Kepka, Cezary ; Kruk, Mariusz ; Vidakovic, Radosav ; Neskovic, Aleksandar N. ; Lecumberri, Iñigo ; Diez Gonzales, Ignacio ; Ruzsics, Balazs ; Fisher, Mike ; Dewey, Marc ; Francone, Marco</creator><creatorcontrib>De Rubeis, Gianluca ; Napp, Adriane E. ; Schlattmann, Peter ; Geleijns, Jacob ; Laule, Michael ; Dreger, Henryk ; Kofoed, Klaus ; Sørgaard, Mathias ; Engstrøm, Thomas ; Tilsted, Hans Henrik ; Boi, Alberto ; Porcu, Michele ; Cossa, Stefano ; Rodríguez-Palomares, José F. ; Xavier Valente, Filipa ; Roque, Albert ; Feuchtner, Gudrun ; Plank, Fabian ; Štěchovský, Cyril ; Adla, Theodor ; Schroeder, Stephen ; Zelesny, Thomas ; Gutberlet, Matthias ; Woinke, Michael ; Károlyi, Mihály ; Karády, Júlia ; Donnelly, Patrick ; Ball, Peter ; Dodd, Jonathan ; Hensey, Mark ; Mancone, Massimo ; Ceccacci, Andrea ; Berzina, Marina ; Zvaigzne, Ligita ; Sakalyte, Gintare ; Basevičius, Algidas ; Ilnicka-Suckiel, Małgorzata ; Kuśmierz, Donata ; Faria, Rita ; Gama-Ribeiro, Vasco ; Benedek, Imre ; Benedek, Teodora ; Adjić, Filip ; Čanković, Milenko ; Berry, Colin ; Delles, Christian ; Thwaite, Erica ; Davis, Gershan ; Knuuti, Juhani ; Pietilä, Mikko ; Kepka, Cezary ; Kruk, Mariusz ; Vidakovic, Radosav ; Neskovic, Aleksandar N. ; Lecumberri, Iñigo ; Diez Gonzales, Ignacio ; Ruzsics, Balazs ; Fisher, Mike ; Dewey, Marc ; Francone, Marco ; DISCHARGE Trial Group ; The DISCHARGE Trial Group</creatorcontrib><description>Objective
To implement detailed EU cardiac computed tomography angiography (CCTA) quality criteria in the multicentre DISCHARGE trial (FP72007-2013, EC-GA 603266), we reviewed image quality and adherence to CCTA protocol and to the recommendations of invasive coronary angiography (ICA) in a pilot study.
Materials and methods
From every clinical centre, imaging datasets of three patients per arm were assessed for adherence to the inclusion/exclusion criteria of the pilot study, predefined standards for the CCTA protocol and ICA recommendations, image quality and non-diagnostic (NDX) rate. These parameters were compared via multinomial regression and ANOVA. If a site did not reach the minimum quality level, additional datasets had to be sent before entering into the final accepted database (FADB).
Results
We analysed 226 cases (150 CCTA/76 ICA). The inclusion/exclusion criteria were not met by 6 of the 226 (2.7%) datasets. The predefined standard was not met by 13 of 76 ICA datasets (17.1%). This percentage decreased between the initial CCTA database and the FADB (multinomial regression, 53 of 70 vs 17 of 75 [76%] vs [23%]). The signal-to-noise ratio and contrast-to-noise ratio of the FADB did not improve significantly (ANOVA,
p
= 0.20;
p
= 0.09). The CTA NDX rate was reduced, but not significantly (initial CCTA database 15 of 70 [21.4%]) and FADB 9 of 75 [12%];
p
= 0.13).
Conclusion
We were able to increase conformity to the inclusion/exclusion criteria and CCTA protocol, improve image quality and decrease the CCTA NDX rate by implementing EU CCTA quality criteria and ICA recommendations.
Key Points
•
Failure to meet protocol adherence in cardiac CTA was high in the pilot study (77.6%).
•
Image quality varies between sites and can be improved by feedback given by the core lab.
•
Conformance with new EU cardiac CT quality criteria might render cardiac CTA findings more consistent and comparable.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-019-06522-z</identifier><identifier>PMID: 31844958</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Angiography ; Cardiac ; Computed tomography ; Computed Tomography Angiography - methods ; Coronary Angiography - methods ; Coronary Artery Disease - diagnosis ; Coronary Vessels - diagnostic imaging ; Criteria ; Datasets ; Diagnostic Radiology ; Diagnostic systems ; Discharge ; Female ; Heart ; Humans ; Image quality ; Imaging ; Internal Medicine ; Interventional Radiology ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroradiology ; Pilot Projects ; Quality ; Radiology ; Regression analysis ; Reproducibility of Results ; Signal to noise ratio ; Ultrasound ; Variance analysis</subject><ispartof>European radiology, 2020-04, Vol.30 (4), p.1997-2009</ispartof><rights>European Society of Radiology 2019</rights><rights>European Radiology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-c3bbf88bf9ae6b2118cfefb98ec3e10fccb86a8a69e55c648c6d962ede50fddd3</citedby><cites>FETCH-LOGICAL-c419t-c3bbf88bf9ae6b2118cfefb98ec3e10fccb86a8a69e55c648c6d962ede50fddd3</cites><orcidid>0000-0002-7906-3420</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-019-06522-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-019-06522-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31844958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Rubeis, Gianluca</creatorcontrib><creatorcontrib>Napp, Adriane E.</creatorcontrib><creatorcontrib>Schlattmann, Peter</creatorcontrib><creatorcontrib>Geleijns, Jacob</creatorcontrib><creatorcontrib>Laule, Michael</creatorcontrib><creatorcontrib>Dreger, Henryk</creatorcontrib><creatorcontrib>Kofoed, Klaus</creatorcontrib><creatorcontrib>Sørgaard, Mathias</creatorcontrib><creatorcontrib>Engstrøm, Thomas</creatorcontrib><creatorcontrib>Tilsted, Hans Henrik</creatorcontrib><creatorcontrib>Boi, Alberto</creatorcontrib><creatorcontrib>Porcu, Michele</creatorcontrib><creatorcontrib>Cossa, Stefano</creatorcontrib><creatorcontrib>Rodríguez-Palomares, José F.</creatorcontrib><creatorcontrib>Xavier Valente, Filipa</creatorcontrib><creatorcontrib>Roque, Albert</creatorcontrib><creatorcontrib>Feuchtner, Gudrun</creatorcontrib><creatorcontrib>Plank, Fabian</creatorcontrib><creatorcontrib>Štěchovský, Cyril</creatorcontrib><creatorcontrib>Adla, Theodor</creatorcontrib><creatorcontrib>Schroeder, Stephen</creatorcontrib><creatorcontrib>Zelesny, Thomas</creatorcontrib><creatorcontrib>Gutberlet, Matthias</creatorcontrib><creatorcontrib>Woinke, Michael</creatorcontrib><creatorcontrib>Károlyi, Mihály</creatorcontrib><creatorcontrib>Karády, Júlia</creatorcontrib><creatorcontrib>Donnelly, Patrick</creatorcontrib><creatorcontrib>Ball, Peter</creatorcontrib><creatorcontrib>Dodd, Jonathan</creatorcontrib><creatorcontrib>Hensey, Mark</creatorcontrib><creatorcontrib>Mancone, Massimo</creatorcontrib><creatorcontrib>Ceccacci, Andrea</creatorcontrib><creatorcontrib>Berzina, Marina</creatorcontrib><creatorcontrib>Zvaigzne, Ligita</creatorcontrib><creatorcontrib>Sakalyte, Gintare</creatorcontrib><creatorcontrib>Basevičius, Algidas</creatorcontrib><creatorcontrib>Ilnicka-Suckiel, Małgorzata</creatorcontrib><creatorcontrib>Kuśmierz, Donata</creatorcontrib><creatorcontrib>Faria, Rita</creatorcontrib><creatorcontrib>Gama-Ribeiro, Vasco</creatorcontrib><creatorcontrib>Benedek, Imre</creatorcontrib><creatorcontrib>Benedek, Teodora</creatorcontrib><creatorcontrib>Adjić, Filip</creatorcontrib><creatorcontrib>Čanković, Milenko</creatorcontrib><creatorcontrib>Berry, Colin</creatorcontrib><creatorcontrib>Delles, Christian</creatorcontrib><creatorcontrib>Thwaite, Erica</creatorcontrib><creatorcontrib>Davis, Gershan</creatorcontrib><creatorcontrib>Knuuti, Juhani</creatorcontrib><creatorcontrib>Pietilä, Mikko</creatorcontrib><creatorcontrib>Kepka, Cezary</creatorcontrib><creatorcontrib>Kruk, Mariusz</creatorcontrib><creatorcontrib>Vidakovic, Radosav</creatorcontrib><creatorcontrib>Neskovic, Aleksandar N.</creatorcontrib><creatorcontrib>Lecumberri, Iñigo</creatorcontrib><creatorcontrib>Diez Gonzales, Ignacio</creatorcontrib><creatorcontrib>Ruzsics, Balazs</creatorcontrib><creatorcontrib>Fisher, Mike</creatorcontrib><creatorcontrib>Dewey, Marc</creatorcontrib><creatorcontrib>Francone, Marco</creatorcontrib><creatorcontrib>DISCHARGE Trial Group</creatorcontrib><creatorcontrib>The DISCHARGE Trial Group</creatorcontrib><title>Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objective
To implement detailed EU cardiac computed tomography angiography (CCTA) quality criteria in the multicentre DISCHARGE trial (FP72007-2013, EC-GA 603266), we reviewed image quality and adherence to CCTA protocol and to the recommendations of invasive coronary angiography (ICA) in a pilot study.
Materials and methods
From every clinical centre, imaging datasets of three patients per arm were assessed for adherence to the inclusion/exclusion criteria of the pilot study, predefined standards for the CCTA protocol and ICA recommendations, image quality and non-diagnostic (NDX) rate. These parameters were compared via multinomial regression and ANOVA. If a site did not reach the minimum quality level, additional datasets had to be sent before entering into the final accepted database (FADB).
Results
We analysed 226 cases (150 CCTA/76 ICA). The inclusion/exclusion criteria were not met by 6 of the 226 (2.7%) datasets. The predefined standard was not met by 13 of 76 ICA datasets (17.1%). This percentage decreased between the initial CCTA database and the FADB (multinomial regression, 53 of 70 vs 17 of 75 [76%] vs [23%]). The signal-to-noise ratio and contrast-to-noise ratio of the FADB did not improve significantly (ANOVA,
p
= 0.20;
p
= 0.09). The CTA NDX rate was reduced, but not significantly (initial CCTA database 15 of 70 [21.4%]) and FADB 9 of 75 [12%];
p
= 0.13).
Conclusion
We were able to increase conformity to the inclusion/exclusion criteria and CCTA protocol, improve image quality and decrease the CCTA NDX rate by implementing EU CCTA quality criteria and ICA recommendations.
Key Points
•
Failure to meet protocol adherence in cardiac CTA was high in the pilot study (77.6%).
•
Image quality varies between sites and can be improved by feedback given by the core lab.
•
Conformance with new EU cardiac CT quality criteria might render cardiac CTA findings more consistent and comparable.</description><subject>Angiography</subject><subject>Cardiac</subject><subject>Computed tomography</subject><subject>Computed Tomography Angiography - methods</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Criteria</subject><subject>Datasets</subject><subject>Diagnostic Radiology</subject><subject>Diagnostic systems</subject><subject>Discharge</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Image quality</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroradiology</subject><subject>Pilot Projects</subject><subject>Quality</subject><subject>Radiology</subject><subject>Regression analysis</subject><subject>Reproducibility of Results</subject><subject>Signal to noise ratio</subject><subject>Ultrasound</subject><subject>Variance analysis</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kctu1DAYRi1ERacDL8ACWWLDJtSXXGx21bS0lSq1grKOHPv3jKskntpOpel78L54mgEkFmxsyT7f8eVD6D0lnykhzWkkhHNSECoLUleMFc-v0IKWnBWUiPI1WhDJRdFIWR6jkxgfCCGSls0bdMypKEtZiQX6eed6n3BMk9lhb3HaAB6mPjkNYwqAz6-_r67Ovl1e4PvgVP8Fu0GtAT9Oqndph9Vo8Db45LXvsTIbCDBqwAFidsS9UPthOyUwOPnBr4PabuaUG59UdE-QgeBHFfara3cg3qIjq_oI7w7zEv34enG_uipubi-vV2c3hS6pTIXmXWeF6KxUUHeMUqEt2E4K0BwosVp3olZC1RKqStel0LWRNQMDFbHGGL5En2ZvfsPjBDG1g4sa-l6N4KfYMs4ayRtSkYx-_Ad98FMY8-0y1VS8oSyPS8RmSgcfYwDbbkP-sbBrKWn3pbVzaW0urX0prX3OoQ8H9dQNYP5EfreUAT4DMW-Nawh_z_6P9he4J6be</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>De Rubeis, Gianluca</creator><creator>Napp, Adriane E.</creator><creator>Schlattmann, Peter</creator><creator>Geleijns, Jacob</creator><creator>Laule, Michael</creator><creator>Dreger, Henryk</creator><creator>Kofoed, Klaus</creator><creator>Sørgaard, Mathias</creator><creator>Engstrøm, Thomas</creator><creator>Tilsted, Hans Henrik</creator><creator>Boi, Alberto</creator><creator>Porcu, Michele</creator><creator>Cossa, Stefano</creator><creator>Rodríguez-Palomares, José F.</creator><creator>Xavier Valente, Filipa</creator><creator>Roque, Albert</creator><creator>Feuchtner, Gudrun</creator><creator>Plank, Fabian</creator><creator>Štěchovský, Cyril</creator><creator>Adla, Theodor</creator><creator>Schroeder, Stephen</creator><creator>Zelesny, Thomas</creator><creator>Gutberlet, Matthias</creator><creator>Woinke, Michael</creator><creator>Károlyi, Mihály</creator><creator>Karády, Júlia</creator><creator>Donnelly, Patrick</creator><creator>Ball, Peter</creator><creator>Dodd, Jonathan</creator><creator>Hensey, Mark</creator><creator>Mancone, Massimo</creator><creator>Ceccacci, Andrea</creator><creator>Berzina, 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study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography</title><author>De Rubeis, Gianluca ; Napp, Adriane E. ; Schlattmann, Peter ; Geleijns, Jacob ; Laule, Michael ; Dreger, Henryk ; Kofoed, Klaus ; Sørgaard, Mathias ; Engstrøm, Thomas ; Tilsted, Hans Henrik ; Boi, Alberto ; Porcu, Michele ; Cossa, Stefano ; Rodríguez-Palomares, José F. ; Xavier Valente, Filipa ; Roque, Albert ; Feuchtner, Gudrun ; Plank, Fabian ; Štěchovský, Cyril ; Adla, Theodor ; Schroeder, Stephen ; Zelesny, Thomas ; Gutberlet, Matthias ; Woinke, Michael ; Károlyi, Mihály ; Karády, Júlia ; Donnelly, Patrick ; Ball, Peter ; Dodd, Jonathan ; Hensey, Mark ; Mancone, Massimo ; Ceccacci, Andrea ; Berzina, Marina ; Zvaigzne, Ligita ; Sakalyte, Gintare ; Basevičius, Algidas ; Ilnicka-Suckiel, Małgorzata ; Kuśmierz, Donata ; Faria, Rita ; Gama-Ribeiro, Vasco ; Benedek, Imre ; Benedek, Teodora ; Adjić, Filip ; Čanković, Milenko ; Berry, Colin ; Delles, Christian ; Thwaite, Erica ; Davis, Gershan ; Knuuti, Juhani ; Pietilä, Mikko ; Kepka, Cezary ; Kruk, Mariusz ; Vidakovic, Radosav ; Neskovic, Aleksandar N. ; Lecumberri, Iñigo ; Diez Gonzales, Ignacio ; Ruzsics, Balazs ; Fisher, Mike ; Dewey, Marc ; Francone, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-c3bbf88bf9ae6b2118cfefb98ec3e10fccb86a8a69e55c648c6d962ede50fddd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Angiography</topic><topic>Cardiac</topic><topic>Computed tomography</topic><topic>Computed Tomography Angiography - methods</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Criteria</topic><topic>Datasets</topic><topic>Diagnostic Radiology</topic><topic>Diagnostic systems</topic><topic>Discharge</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Image quality</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuroradiology</topic><topic>Pilot Projects</topic><topic>Quality</topic><topic>Radiology</topic><topic>Regression analysis</topic><topic>Reproducibility of Results</topic><topic>Signal to noise ratio</topic><topic>Ultrasound</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Rubeis, Gianluca</creatorcontrib><creatorcontrib>Napp, Adriane E.</creatorcontrib><creatorcontrib>Schlattmann, Peter</creatorcontrib><creatorcontrib>Geleijns, Jacob</creatorcontrib><creatorcontrib>Laule, Michael</creatorcontrib><creatorcontrib>Dreger, Henryk</creatorcontrib><creatorcontrib>Kofoed, Klaus</creatorcontrib><creatorcontrib>Sørgaard, Mathias</creatorcontrib><creatorcontrib>Engstrøm, Thomas</creatorcontrib><creatorcontrib>Tilsted, Hans Henrik</creatorcontrib><creatorcontrib>Boi, Alberto</creatorcontrib><creatorcontrib>Porcu, Michele</creatorcontrib><creatorcontrib>Cossa, Stefano</creatorcontrib><creatorcontrib>Rodríguez-Palomares, José F.</creatorcontrib><creatorcontrib>Xavier Valente, Filipa</creatorcontrib><creatorcontrib>Roque, Albert</creatorcontrib><creatorcontrib>Feuchtner, Gudrun</creatorcontrib><creatorcontrib>Plank, Fabian</creatorcontrib><creatorcontrib>Štěchovský, Cyril</creatorcontrib><creatorcontrib>Adla, Theodor</creatorcontrib><creatorcontrib>Schroeder, Stephen</creatorcontrib><creatorcontrib>Zelesny, Thomas</creatorcontrib><creatorcontrib>Gutberlet, Matthias</creatorcontrib><creatorcontrib>Woinke, Michael</creatorcontrib><creatorcontrib>Károlyi, Mihály</creatorcontrib><creatorcontrib>Karády, Júlia</creatorcontrib><creatorcontrib>Donnelly, Patrick</creatorcontrib><creatorcontrib>Ball, Peter</creatorcontrib><creatorcontrib>Dodd, Jonathan</creatorcontrib><creatorcontrib>Hensey, Mark</creatorcontrib><creatorcontrib>Mancone, Massimo</creatorcontrib><creatorcontrib>Ceccacci, Andrea</creatorcontrib><creatorcontrib>Berzina, Marina</creatorcontrib><creatorcontrib>Zvaigzne, Ligita</creatorcontrib><creatorcontrib>Sakalyte, Gintare</creatorcontrib><creatorcontrib>Basevičius, Algidas</creatorcontrib><creatorcontrib>Ilnicka-Suckiel, Małgorzata</creatorcontrib><creatorcontrib>Kuśmierz, Donata</creatorcontrib><creatorcontrib>Faria, Rita</creatorcontrib><creatorcontrib>Gama-Ribeiro, Vasco</creatorcontrib><creatorcontrib>Benedek, Imre</creatorcontrib><creatorcontrib>Benedek, Teodora</creatorcontrib><creatorcontrib>Adjić, Filip</creatorcontrib><creatorcontrib>Čanković, Milenko</creatorcontrib><creatorcontrib>Berry, Colin</creatorcontrib><creatorcontrib>Delles, Christian</creatorcontrib><creatorcontrib>Thwaite, Erica</creatorcontrib><creatorcontrib>Davis, Gershan</creatorcontrib><creatorcontrib>Knuuti, Juhani</creatorcontrib><creatorcontrib>Pietilä, Mikko</creatorcontrib><creatorcontrib>Kepka, Cezary</creatorcontrib><creatorcontrib>Kruk, Mariusz</creatorcontrib><creatorcontrib>Vidakovic, Radosav</creatorcontrib><creatorcontrib>Neskovic, Aleksandar N.</creatorcontrib><creatorcontrib>Lecumberri, Iñigo</creatorcontrib><creatorcontrib>Diez Gonzales, Ignacio</creatorcontrib><creatorcontrib>Ruzsics, Balazs</creatorcontrib><creatorcontrib>Fisher, Mike</creatorcontrib><creatorcontrib>Dewey, Marc</creatorcontrib><creatorcontrib>Francone, Marco</creatorcontrib><creatorcontrib>DISCHARGE Trial Group</creatorcontrib><creatorcontrib>The DISCHARGE Trial Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Rubeis, Gianluca</au><au>Napp, Adriane E.</au><au>Schlattmann, Peter</au><au>Geleijns, Jacob</au><au>Laule, Michael</au><au>Dreger, Henryk</au><au>Kofoed, Klaus</au><au>Sørgaard, Mathias</au><au>Engstrøm, Thomas</au><au>Tilsted, Hans Henrik</au><au>Boi, Alberto</au><au>Porcu, Michele</au><au>Cossa, Stefano</au><au>Rodríguez-Palomares, José F.</au><au>Xavier Valente, Filipa</au><au>Roque, Albert</au><au>Feuchtner, Gudrun</au><au>Plank, Fabian</au><au>Štěchovský, Cyril</au><au>Adla, Theodor</au><au>Schroeder, Stephen</au><au>Zelesny, Thomas</au><au>Gutberlet, Matthias</au><au>Woinke, Michael</au><au>Károlyi, Mihály</au><au>Karády, Júlia</au><au>Donnelly, Patrick</au><au>Ball, Peter</au><au>Dodd, Jonathan</au><au>Hensey, Mark</au><au>Mancone, Massimo</au><au>Ceccacci, Andrea</au><au>Berzina, Marina</au><au>Zvaigzne, Ligita</au><au>Sakalyte, Gintare</au><au>Basevičius, Algidas</au><au>Ilnicka-Suckiel, Małgorzata</au><au>Kuśmierz, Donata</au><au>Faria, Rita</au><au>Gama-Ribeiro, Vasco</au><au>Benedek, Imre</au><au>Benedek, Teodora</au><au>Adjić, Filip</au><au>Čanković, Milenko</au><au>Berry, Colin</au><au>Delles, Christian</au><au>Thwaite, Erica</au><au>Davis, Gershan</au><au>Knuuti, Juhani</au><au>Pietilä, Mikko</au><au>Kepka, Cezary</au><au>Kruk, Mariusz</au><au>Vidakovic, Radosav</au><au>Neskovic, Aleksandar N.</au><au>Lecumberri, Iñigo</au><au>Diez Gonzales, Ignacio</au><au>Ruzsics, Balazs</au><au>Fisher, Mike</au><au>Dewey, Marc</au><au>Francone, Marco</au><aucorp>DISCHARGE Trial Group</aucorp><aucorp>The DISCHARGE Trial Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>30</volume><issue>4</issue><spage>1997</spage><epage>2009</epage><pages>1997-2009</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objective
To implement detailed EU cardiac computed tomography angiography (CCTA) quality criteria in the multicentre DISCHARGE trial (FP72007-2013, EC-GA 603266), we reviewed image quality and adherence to CCTA protocol and to the recommendations of invasive coronary angiography (ICA) in a pilot study.
Materials and methods
From every clinical centre, imaging datasets of three patients per arm were assessed for adherence to the inclusion/exclusion criteria of the pilot study, predefined standards for the CCTA protocol and ICA recommendations, image quality and non-diagnostic (NDX) rate. These parameters were compared via multinomial regression and ANOVA. If a site did not reach the minimum quality level, additional datasets had to be sent before entering into the final accepted database (FADB).
Results
We analysed 226 cases (150 CCTA/76 ICA). The inclusion/exclusion criteria were not met by 6 of the 226 (2.7%) datasets. The predefined standard was not met by 13 of 76 ICA datasets (17.1%). This percentage decreased between the initial CCTA database and the FADB (multinomial regression, 53 of 70 vs 17 of 75 [76%] vs [23%]). The signal-to-noise ratio and contrast-to-noise ratio of the FADB did not improve significantly (ANOVA,
p
= 0.20;
p
= 0.09). The CTA NDX rate was reduced, but not significantly (initial CCTA database 15 of 70 [21.4%]) and FADB 9 of 75 [12%];
p
= 0.13).
Conclusion
We were able to increase conformity to the inclusion/exclusion criteria and CCTA protocol, improve image quality and decrease the CCTA NDX rate by implementing EU CCTA quality criteria and ICA recommendations.
Key Points
•
Failure to meet protocol adherence in cardiac CTA was high in the pilot study (77.6%).
•
Image quality varies between sites and can be improved by feedback given by the core lab.
•
Conformance with new EU cardiac CT quality criteria might render cardiac CTA findings more consistent and comparable.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31844958</pmid><doi>10.1007/s00330-019-06522-z</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-7906-3420</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2020-04, Vol.30 (4), p.1997-2009 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2327937050 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Angiography Cardiac Computed tomography Computed Tomography Angiography - methods Coronary Angiography - methods Coronary Artery Disease - diagnosis Coronary Vessels - diagnostic imaging Criteria Datasets Diagnostic Radiology Diagnostic systems Discharge Female Heart Humans Image quality Imaging Internal Medicine Interventional Radiology Male Medical imaging Medicine Medicine & Public Health Middle Aged Neuroradiology Pilot Projects Quality Radiology Regression analysis Reproducibility of Results Signal to noise ratio Ultrasound Variance analysis |
| title | Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography |
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