The role of cytochrome P4502E1 in the pathogenesis of alcoholic liver disease and carcinogenesis

The role of cytochrome P4502E1 in the pathogenesis of alcoholic liver disease and carcinogenesis

•Chronic alcohol ingestion induces cytochrome P4502E1.•CYP-4502E1 activates procarcinogens, degradates retinoids and generates free radicals.•Cytochrome P4502E1 is a pathogenic factor in alcoholic liver disease.•Cytochrome P4502E1 is a pathogenic factor in alcohol mediated carcinogenesis.•Inhibition...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemico-biological interactions 2020-01, Vol.316, p.108918-108918, Article 108918
1. Verfasser: Seitz, Helmut K.
Format: Artikel
Sprache:eng
Schlagworte:
Alcoholic Intoxication - drug therapy
Animals
Carcinogenesis - metabolism
Cell Line, Tumor
Chlormethiazole - therapeutic use
Cytochrome P-450 CYP2E1 - metabolism
Cytochrome P-450 CYP2E1 Inhibitors - therapeutic use
Ethanol - metabolism
Ethanol - toxicity
Humans
Liver Cirrhosis - etiology
Liver Diseases, Alcoholic - etiology
Liver Neoplasms - etiology
Non-alcoholic Fatty Liver Disease - etiology
Tretinoin - metabolism
Vitamin A - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•Chronic alcohol ingestion induces cytochrome P4502E1.•CYP-4502E1 activates procarcinogens, degradates retinoids and generates free radicals.•Cytochrome P4502E1 is a pathogenic factor in alcoholic liver disease.•Cytochrome P4502E1 is a pathogenic factor in alcohol mediated carcinogenesis.•Inhibition of cytochrome P4502E1 improves alcoholic liver disease.
ISSN:0009-2797
1872-7786
DOI:10.1016/j.cbi.2019.108918