The discovery of potent and stable short peptide FGFR1 antagonist for cancer therapy

Fibroblast growth factor receptor 1 (FGFR1) is one of the attractive pharmaceutical targets for cancer therapy. The FGFR1 targeting antagonist peptides, especially of the short peptides harbouring only coding amino acid might highlights promising aspects for their higher affinity, specificity and lo...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2020-02, Vol.143, p.105179-105179, Article 105179
Hauptverfasser:	Wu, Jianzhang, Chen, Lingzi, Chen, Liping, Fan, Lei, Wang, Zhe, Dong, Zhaojun, Chen, Qian, Wei, Tao, Cai, Yuepiao, Li, Wulan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use antitumor drug BALB 3T3 Cells Cell Line, Tumor FGFR1 inhibitor HEK293 Cells Humans Mice Mice, Inbred BALB C Mice, Nude Neoplasms - drug therapy Neoplasms - pathology Oligopeptides - pharmacology Oligopeptides - therapeutic use Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors Short peptide Signal Transduction - drug effects Spatial structure Stability Tumor Burden - drug effects Xenograft Model Antitumor Assays
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