Comparison of salvage surgery for recurrent or residual head and neck squamous cell carcinoma

Comparison of salvage surgery for recurrent or residual head and neck squamous cell carcinoma

Abstract Objective Concomitant chemoradiation therapy is a standard treatment for head and neck cancer. Thus, salvage surgery has become a necessary treatment. The aim of the study was to evaluate the results of salvage surgery by each site of the head and neck, especially the oropharynx, hypopharyn...

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Veröffentlicht in:Japanese journal of clinical oncology 2020-03, Vol.50 (3), p.288-295
Hauptverfasser: Maruo, Takashi, Zenda, Sadamoto, Shinozaki, Takeshi, Tomioka, Toshifumi, Okano, Wataru, Sakuraba, Minoru, Tahara, Makoto, Hayashi, Ryuichi
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container_end_page 295
container_issue 3
container_start_page 288
container_title Japanese journal of clinical oncology
container_volume 50
creator Maruo, Takashi
Zenda, Sadamoto
Shinozaki, Takeshi
Tomioka, Toshifumi
Okano, Wataru
Sakuraba, Minoru
Tahara, Makoto
Hayashi, Ryuichi
description Abstract Objective Concomitant chemoradiation therapy is a standard treatment for head and neck cancer. Thus, salvage surgery has become a necessary treatment. The aim of the study was to evaluate the results of salvage surgery by each site of the head and neck, especially the oropharynx, hypopharynx and larynx. Methods This was a retrospective, single-institute study. The primary endpoint was overall survival. Secondary endpoints were disease-free survival, the locoregional control rate after salvage surgery, the indication rate for salvage surgery, the reasons for contraindications to salvage surgery, the post-operative complication rate and the predictors of survival. Results Three-year overall survival after salvage surgery was 58.8% in the salvage surgery group and 8.59% in the other treatment group (P 
doi_str_mv 10.1093/jjco/hyz176
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Thus, salvage surgery has become a necessary treatment. The aim of the study was to evaluate the results of salvage surgery by each site of the head and neck, especially the oropharynx, hypopharynx and larynx. Methods This was a retrospective, single-institute study. The primary endpoint was overall survival. Secondary endpoints were disease-free survival, the locoregional control rate after salvage surgery, the indication rate for salvage surgery, the reasons for contraindications to salvage surgery, the post-operative complication rate and the predictors of survival. Results Three-year overall survival after salvage surgery was 58.8% in the salvage surgery group and 8.59% in the other treatment group (P &lt; 0.0001). Regarding overall survival and disease-free survival after salvage surgery, there was no difference among sites. Regarding locoregional control rate among sites, there was no significant difference. The oropharyngeal cancer group had the lowest rate of salvage primary resection. Surgical margin and local and regional recurrence or residual disease were predictors on univariate and multivariate analyses. Conclusions Salvage surgery is effective for recurrent or residual cases after concomitant chemoradiation therapy. For oropharyngeal cancer, local control is important, and for oropharyngeal cancer and hypopharyngeal cancer, distant metastasis is important. Salvage surgery for head and neck cancer has become a necessary treatment. This article evaluates the results of salvage surgery by each site of the head and neck.</description><identifier>ISSN: 1465-3621</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hyz176</identifier><identifier>PMID: 31845736</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><ispartof>Japanese journal of clinical oncology, 2020-03, Vol.50 (3), p.288-295</ispartof><rights>The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-d4c01a06e144b49b1c3d5d0b9e94bedbe5b09426dfc6a14603d7a6c8ea55c73</citedby><cites>FETCH-LOGICAL-c447t-d4c01a06e144b49b1c3d5d0b9e94bedbe5b09426dfc6a14603d7a6c8ea55c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31845736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maruo, Takashi</creatorcontrib><creatorcontrib>Zenda, Sadamoto</creatorcontrib><creatorcontrib>Shinozaki, Takeshi</creatorcontrib><creatorcontrib>Tomioka, Toshifumi</creatorcontrib><creatorcontrib>Okano, Wataru</creatorcontrib><creatorcontrib>Sakuraba, Minoru</creatorcontrib><creatorcontrib>Tahara, Makoto</creatorcontrib><creatorcontrib>Hayashi, Ryuichi</creatorcontrib><title>Comparison of salvage surgery for recurrent or residual head and neck squamous cell carcinoma</title><title>Japanese journal of clinical oncology</title><addtitle>Jpn J Clin Oncol</addtitle><description>Abstract Objective Concomitant chemoradiation therapy is a standard treatment for head and neck cancer. Thus, salvage surgery has become a necessary treatment. The aim of the study was to evaluate the results of salvage surgery by each site of the head and neck, especially the oropharynx, hypopharynx and larynx. Methods This was a retrospective, single-institute study. The primary endpoint was overall survival. Secondary endpoints were disease-free survival, the locoregional control rate after salvage surgery, the indication rate for salvage surgery, the reasons for contraindications to salvage surgery, the post-operative complication rate and the predictors of survival. Results Three-year overall survival after salvage surgery was 58.8% in the salvage surgery group and 8.59% in the other treatment group (P &lt; 0.0001). Regarding overall survival and disease-free survival after salvage surgery, there was no difference among sites. Regarding locoregional control rate among sites, there was no significant difference. The oropharyngeal cancer group had the lowest rate of salvage primary resection. Surgical margin and local and regional recurrence or residual disease were predictors on univariate and multivariate analyses. Conclusions Salvage surgery is effective for recurrent or residual cases after concomitant chemoradiation therapy. For oropharyngeal cancer, local control is important, and for oropharyngeal cancer and hypopharyngeal cancer, distant metastasis is important. Salvage surgery for head and neck cancer has become a necessary treatment. 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Thus, salvage surgery has become a necessary treatment. The aim of the study was to evaluate the results of salvage surgery by each site of the head and neck, especially the oropharynx, hypopharynx and larynx. Methods This was a retrospective, single-institute study. The primary endpoint was overall survival. Secondary endpoints were disease-free survival, the locoregional control rate after salvage surgery, the indication rate for salvage surgery, the reasons for contraindications to salvage surgery, the post-operative complication rate and the predictors of survival. Results Three-year overall survival after salvage surgery was 58.8% in the salvage surgery group and 8.59% in the other treatment group (P &lt; 0.0001). Regarding overall survival and disease-free survival after salvage surgery, there was no difference among sites. Regarding locoregional control rate among sites, there was no significant difference. The oropharyngeal cancer group had the lowest rate of salvage primary resection. Surgical margin and local and regional recurrence or residual disease were predictors on univariate and multivariate analyses. Conclusions Salvage surgery is effective for recurrent or residual cases after concomitant chemoradiation therapy. For oropharyngeal cancer, local control is important, and for oropharyngeal cancer and hypopharyngeal cancer, distant metastasis is important. Salvage surgery for head and neck cancer has become a necessary treatment. This article evaluates the results of salvage surgery by each site of the head and neck.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>31845736</pmid><doi>10.1093/jjco/hyz176</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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source Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
title Comparison of salvage surgery for recurrent or residual head and neck squamous cell carcinoma
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