Blockade of 5‐HT2 receptors with sarpogrelate uncovers 5‐HT7 receptors inhibiting the tachycardic sympathetic drive in pithed rats

Our group has previously shown in pithed rats that the cardiac sympathetic drive, which produces tachycardic responses, is inhibited by 5‐HT via the activation of prejunctional 5‐HT1B/1D/5 receptors. Interestingly, when 5‐HT2 receptors are chronically blocked with sarpogrelate, the additional role o...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2020-03, Vol.47 (3), p.403-411
Hauptverfasser:	Hernández‐Abreu, Oswaldo I., García‐Pedraza, José Á., Rivera‐Mancilla, Eduardo, Villanueva‐Castillo, Belinda, Morán, Asunción, García‐Domingo, Mónica, Manrique‐Maldonado, Guadalupe, Altamirano‐Espinoza, Alain H., Villalón, Carlos M.
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐HT2 receptor blockade 5‐HT7 receptors AS‐19 ATP cardiac sympatho‐inhibition Drinking water Glibenclamide Heart rate Hyperpolarization Modulation Neurotransmission Noradrenaline Norepinephrine pithed rat Potassium channels Receptors Rodents sarpogrelate SB258719 Stimulation Sympathetic nervous system Tachycardia Vagus nerve
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