Novel fluoride and stannous -functionalized β-tricalcium phosphate nanoparticles for the management of dental erosion
To evaluate the anti-erosive effect of solutions containing β-tricalcium phosphate (β-TCP) nanoparticles functionalized with fluoride or with fluoride plus stannous on enamel and dentin. β-TCP nanoparticles were synthesized and characterized by X-ray diffraction (XRD) and transmission electron micro...
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| Veröffentlicht in: | Journal of dentistry 2020-01, Vol.92, p.103263-103263, Article 103263 |
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| container_title | Journal of dentistry |
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| creator | Viana, Ítallo Emídio Lira Lopes, Raquel Marianna Silva, Flávia Rodrigues Oliveira Lima, Nelson Batista Aranha, Ana Cecília Corrêa Feitosa, Sabrina Scaramucci, Taís |
| description | To evaluate the anti-erosive effect of solutions containing β-tricalcium phosphate (β-TCP) nanoparticles functionalized with fluoride or with fluoride plus stannous on enamel and dentin.
β-TCP nanoparticles were synthesized and characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Sixty enamel and dentin specimens were randomly allocated into the groups (n = 10): Control (water); F (NaF, 225 ppm F−); F + Sn (NaF + SnCl2, 800 ppm Sn2+); F+β-TCP (F+40 ppm β-TCP); F + Sn+β-TCP (F + Sn+40 ppm β-TCP); F + Sn+100β-TCP (F + Sn+100 ppm β-TCP). Specimens underwent erosion-remineralization cycling (5 min immersion into 1 % citric acid solution and 60 min exposure to artificial saliva, 4×/day, 5 days). Immersion in the test solutions was performed for 2 min, 2×/day. Surface loss (SL, in μm) was determined by optical profilometry at the end of cycling. Data were analyzed using one way-ANOVA and Tukey’s tests (α = 0.05).
XRD confirmed the β-TCP phase. TEM micrographs showed differences between the bare nanoparticle and the β-TCP functionalized with F and Sn. All enamel groups presented lower SL than the control, with F + Sn, F + Sn+β-TCP, and F + Sn+100β-TCP showing the lowest values. For dentin, all the groups had lower SL than the control. F+β-TCP presented the lowest SL, significantly differing from all the other groups.
β-TCP nanoparticles functionalized with fluoride showed improved anti-erosive effect compared to the fluoride solution on dentin. There was no significant effect of the β-TCP nanoparticles functionalized with fluoride plus stannous in both substrates.
β-TCP nanoparticles are a promising agent to be added to oral health products to improve the protective effect of fluoride against dentin erosion. |
| doi_str_mv | 10.1016/j.jdent.2019.103263 |
| format | Article |
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β-TCP nanoparticles were synthesized and characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Sixty enamel and dentin specimens were randomly allocated into the groups (n = 10): Control (water); F (NaF, 225 ppm F−); F + Sn (NaF + SnCl2, 800 ppm Sn2+); F+β-TCP (F+40 ppm β-TCP); F + Sn+β-TCP (F + Sn+40 ppm β-TCP); F + Sn+100β-TCP (F + Sn+100 ppm β-TCP). Specimens underwent erosion-remineralization cycling (5 min immersion into 1 % citric acid solution and 60 min exposure to artificial saliva, 4×/day, 5 days). Immersion in the test solutions was performed for 2 min, 2×/day. Surface loss (SL, in μm) was determined by optical profilometry at the end of cycling. Data were analyzed using one way-ANOVA and Tukey’s tests (α = 0.05).
XRD confirmed the β-TCP phase. TEM micrographs showed differences between the bare nanoparticle and the β-TCP functionalized with F and Sn. All enamel groups presented lower SL than the control, with F + Sn, F + Sn+β-TCP, and F + Sn+100β-TCP showing the lowest values. For dentin, all the groups had lower SL than the control. F+β-TCP presented the lowest SL, significantly differing from all the other groups.
β-TCP nanoparticles functionalized with fluoride showed improved anti-erosive effect compared to the fluoride solution on dentin. There was no significant effect of the β-TCP nanoparticles functionalized with fluoride plus stannous in both substrates.
β-TCP nanoparticles are a promising agent to be added to oral health products to improve the protective effect of fluoride against dentin erosion.</description><identifier>ISSN: 0300-5712</identifier><identifier>EISSN: 1879-176X</identifier><identifier>DOI: 10.1016/j.jdent.2019.103263</identifier><identifier>PMID: 31838138</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acids ; Calcium phosphates ; Citric acid ; Cycles ; Dental enamel ; Dental erosion ; Dentin ; Dentistry ; Dietary minerals ; Enamel ; Fluoride ; Fluorides ; Immersion ; Micrography ; Nanoparticles ; Phosphates ; Photomicrographs ; Remineralization ; Saliva ; Spectrum analysis ; Stannous ; Submerging ; Substrates ; Tooth erosion ; Transmission electron microscopy ; Tricalcium phosphate ; X-ray diffraction ; β-TCP nanoparticles</subject><ispartof>Journal of dentistry, 2020-01, Vol.92, p.103263-103263, Article 103263</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><rights>2019. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-c538eca2c4df2a7441d42978d0744531ffd6e79b1c4e090973656c543dddd1653</citedby><cites>FETCH-LOGICAL-c387t-c538eca2c4df2a7441d42978d0744531ffd6e79b1c4e090973656c543dddd1653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0300571219302738$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31838138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Viana, Ítallo Emídio Lira</creatorcontrib><creatorcontrib>Lopes, Raquel Marianna</creatorcontrib><creatorcontrib>Silva, Flávia Rodrigues Oliveira</creatorcontrib><creatorcontrib>Lima, Nelson Batista</creatorcontrib><creatorcontrib>Aranha, Ana Cecília Corrêa</creatorcontrib><creatorcontrib>Feitosa, Sabrina</creatorcontrib><creatorcontrib>Scaramucci, Taís</creatorcontrib><title>Novel fluoride and stannous -functionalized β-tricalcium phosphate nanoparticles for the management of dental erosion</title><title>Journal of dentistry</title><addtitle>J Dent</addtitle><description>To evaluate the anti-erosive effect of solutions containing β-tricalcium phosphate (β-TCP) nanoparticles functionalized with fluoride or with fluoride plus stannous on enamel and dentin.
β-TCP nanoparticles were synthesized and characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Sixty enamel and dentin specimens were randomly allocated into the groups (n = 10): Control (water); F (NaF, 225 ppm F−); F + Sn (NaF + SnCl2, 800 ppm Sn2+); F+β-TCP (F+40 ppm β-TCP); F + Sn+β-TCP (F + Sn+40 ppm β-TCP); F + Sn+100β-TCP (F + Sn+100 ppm β-TCP). Specimens underwent erosion-remineralization cycling (5 min immersion into 1 % citric acid solution and 60 min exposure to artificial saliva, 4×/day, 5 days). Immersion in the test solutions was performed for 2 min, 2×/day. Surface loss (SL, in μm) was determined by optical profilometry at the end of cycling. Data were analyzed using one way-ANOVA and Tukey’s tests (α = 0.05).
XRD confirmed the β-TCP phase. TEM micrographs showed differences between the bare nanoparticle and the β-TCP functionalized with F and Sn. All enamel groups presented lower SL than the control, with F + Sn, F + Sn+β-TCP, and F + Sn+100β-TCP showing the lowest values. For dentin, all the groups had lower SL than the control. F+β-TCP presented the lowest SL, significantly differing from all the other groups.
β-TCP nanoparticles functionalized with fluoride showed improved anti-erosive effect compared to the fluoride solution on dentin. There was no significant effect of the β-TCP nanoparticles functionalized with fluoride plus stannous in both substrates.
β-TCP nanoparticles are a promising agent to be added to oral health products to improve the protective effect of fluoride against dentin erosion.</description><subject>Acids</subject><subject>Calcium phosphates</subject><subject>Citric acid</subject><subject>Cycles</subject><subject>Dental enamel</subject><subject>Dental erosion</subject><subject>Dentin</subject><subject>Dentistry</subject><subject>Dietary minerals</subject><subject>Enamel</subject><subject>Fluoride</subject><subject>Fluorides</subject><subject>Immersion</subject><subject>Micrography</subject><subject>Nanoparticles</subject><subject>Phosphates</subject><subject>Photomicrographs</subject><subject>Remineralization</subject><subject>Saliva</subject><subject>Spectrum analysis</subject><subject>Stannous</subject><subject>Submerging</subject><subject>Substrates</subject><subject>Tooth erosion</subject><subject>Transmission electron microscopy</subject><subject>Tricalcium phosphate</subject><subject>X-ray diffraction</subject><subject>β-TCP nanoparticles</subject><issn>0300-5712</issn><issn>1879-176X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UcuO1DAQtBCInR34AiRkiQuXDH4kcXLggFawIK3gAhI3y2u3GUeOHWxnJPgsPoRvwmEWDhzoi1tWdXVXFUJPKDlQQvsX02EyEMqBETrWH856fg_t6CDGhor-8320I5yQphOUXaDLnCdCSEvY-BBdcDrwgfJhh07v4wk8tn6NyRnAKhiciwohrhk3dg26uBiUd9_B4J8_mpKcVl67dcbLMeblqArgoEJcVCpOe8jYxoTLEfCsgvoCcz0RR4u3U5XHkGKuhI_QA6t8hsd37x59evP649Xb5ubD9burVzeN5oMoje74AFox3RrLlGhbalo2isGQ2necWmt6EOMt1S2QkYyC912vu5abWrTv-B49P_MuKX5dIRc5u6zBexWgKpSMM7E5Uf3Yo2f_QKe4pip9Q3E-knas_HvEzyhdheQEVi7JzSp9k5TILRY5yd-xyC0WeY6lTj29415vZzB_Z_7kUAEvzwCoZpwcJJm1g6DBuAS6SBPdfxf8AiYPoSE</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Viana, Ítallo Emídio Lira</creator><creator>Lopes, Raquel Marianna</creator><creator>Silva, Flávia Rodrigues Oliveira</creator><creator>Lima, Nelson Batista</creator><creator>Aranha, Ana Cecília Corrêa</creator><creator>Feitosa, Sabrina</creator><creator>Scaramucci, Taís</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202001</creationdate><title>Novel fluoride and stannous -functionalized β-tricalcium phosphate nanoparticles for the management of dental erosion</title><author>Viana, Ítallo Emídio Lira ; Lopes, Raquel Marianna ; Silva, Flávia Rodrigues Oliveira ; Lima, Nelson Batista ; Aranha, Ana Cecília Corrêa ; Feitosa, Sabrina ; Scaramucci, Taís</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-c538eca2c4df2a7441d42978d0744531ffd6e79b1c4e090973656c543dddd1653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acids</topic><topic>Calcium phosphates</topic><topic>Citric acid</topic><topic>Cycles</topic><topic>Dental enamel</topic><topic>Dental erosion</topic><topic>Dentin</topic><topic>Dentistry</topic><topic>Dietary minerals</topic><topic>Enamel</topic><topic>Fluoride</topic><topic>Fluorides</topic><topic>Immersion</topic><topic>Micrography</topic><topic>Nanoparticles</topic><topic>Phosphates</topic><topic>Photomicrographs</topic><topic>Remineralization</topic><topic>Saliva</topic><topic>Spectrum analysis</topic><topic>Stannous</topic><topic>Submerging</topic><topic>Substrates</topic><topic>Tooth erosion</topic><topic>Transmission electron microscopy</topic><topic>Tricalcium phosphate</topic><topic>X-ray diffraction</topic><topic>β-TCP nanoparticles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Viana, Ítallo Emídio Lira</creatorcontrib><creatorcontrib>Lopes, Raquel Marianna</creatorcontrib><creatorcontrib>Silva, Flávia Rodrigues Oliveira</creatorcontrib><creatorcontrib>Lima, Nelson Batista</creatorcontrib><creatorcontrib>Aranha, Ana Cecília Corrêa</creatorcontrib><creatorcontrib>Feitosa, Sabrina</creatorcontrib><creatorcontrib>Scaramucci, Taís</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Viana, Ítallo Emídio Lira</au><au>Lopes, Raquel Marianna</au><au>Silva, Flávia Rodrigues Oliveira</au><au>Lima, Nelson Batista</au><au>Aranha, Ana Cecília Corrêa</au><au>Feitosa, Sabrina</au><au>Scaramucci, Taís</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel fluoride and stannous -functionalized β-tricalcium phosphate nanoparticles for the management of dental erosion</atitle><jtitle>Journal of dentistry</jtitle><addtitle>J Dent</addtitle><date>2020-01</date><risdate>2020</risdate><volume>92</volume><spage>103263</spage><epage>103263</epage><pages>103263-103263</pages><artnum>103263</artnum><issn>0300-5712</issn><eissn>1879-176X</eissn><abstract>To evaluate the anti-erosive effect of solutions containing β-tricalcium phosphate (β-TCP) nanoparticles functionalized with fluoride or with fluoride plus stannous on enamel and dentin.
β-TCP nanoparticles were synthesized and characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Sixty enamel and dentin specimens were randomly allocated into the groups (n = 10): Control (water); F (NaF, 225 ppm F−); F + Sn (NaF + SnCl2, 800 ppm Sn2+); F+β-TCP (F+40 ppm β-TCP); F + Sn+β-TCP (F + Sn+40 ppm β-TCP); F + Sn+100β-TCP (F + Sn+100 ppm β-TCP). Specimens underwent erosion-remineralization cycling (5 min immersion into 1 % citric acid solution and 60 min exposure to artificial saliva, 4×/day, 5 days). Immersion in the test solutions was performed for 2 min, 2×/day. Surface loss (SL, in μm) was determined by optical profilometry at the end of cycling. Data were analyzed using one way-ANOVA and Tukey’s tests (α = 0.05).
XRD confirmed the β-TCP phase. TEM micrographs showed differences between the bare nanoparticle and the β-TCP functionalized with F and Sn. All enamel groups presented lower SL than the control, with F + Sn, F + Sn+β-TCP, and F + Sn+100β-TCP showing the lowest values. For dentin, all the groups had lower SL than the control. F+β-TCP presented the lowest SL, significantly differing from all the other groups.
β-TCP nanoparticles functionalized with fluoride showed improved anti-erosive effect compared to the fluoride solution on dentin. There was no significant effect of the β-TCP nanoparticles functionalized with fluoride plus stannous in both substrates.
β-TCP nanoparticles are a promising agent to be added to oral health products to improve the protective effect of fluoride against dentin erosion.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31838138</pmid><doi>10.1016/j.jdent.2019.103263</doi><tpages>1</tpages></addata></record> |
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| ispartof | Journal of dentistry, 2020-01, Vol.92, p.103263-103263, Article 103263 |
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| source | Elsevier ScienceDirect Journals |
| subjects | Acids Calcium phosphates Citric acid Cycles Dental enamel Dental erosion Dentin Dentistry Dietary minerals Enamel Fluoride Fluorides Immersion Micrography Nanoparticles Phosphates Photomicrographs Remineralization Saliva Spectrum analysis Stannous Submerging Substrates Tooth erosion Transmission electron microscopy Tricalcium phosphate X-ray diffraction β-TCP nanoparticles |
| title | Novel fluoride and stannous -functionalized β-tricalcium phosphate nanoparticles for the management of dental erosion |
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