Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders

Gene silencing therapies have successfully suppressed the translation of target proteins, a strategy that holds great promise for the treatment of central nervous system (CNS) disorders. Advances in the current knowledge on multimolecular delivery vehicles are concentrated on overcoming the difficul...

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Veröffentlicht in:	Nanoscale 2020-03, Vol.12 (11), p.6285-6299
Hauptverfasser:	Conejos-Sánchez, I, Gallon, E, Niño-Pariente, A, Smith, J. A, De la Fuente, A. G, Di Canio, L, Pluchino, S, Franklin, R. J. M, Vicent, M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Biodegradability Cell Line, Tumor Cells (biology) Central nervous system Central Nervous System Diseases - genetics Central Nervous System Diseases - metabolism Central Nervous System Diseases - pathology Central Nervous System Diseases - therapy Diffusion rate Disorders Gene expression Gene Silencing Humans Oligodendroglia - metabolism Oligodendroglia - pathology Peptides - chemistry Peptides - pharmacology Polypeptides RNA, Small Interfering - chemistry RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology Stem Cells - metabolism Stem Cells - pathology
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