High-Negative Anti- Helicobacter pylori IgG Antibody Titers and Long-Term Risk of Gastric Cancer: Results from a Large-Scale Population-Based Cohort Study in Japan
Serologic testing of anti- antibody, together with testing of pepsinogen I and II, is now widely used to stratify groups at high risk of gastric cancer in Japan. Those with a negative anti- IgG titer, especially "high-negative" (3-
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2020-02, Vol.29 (2), p.420-426 |
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| creator | Inoue, Manami Sawada, Norie Goto, Atsushi Shimazu, Taichi Yamaji, Taiki Iwasaki, Motoki Tsugane, Shoichiro |
| description | Serologic testing of anti-
antibody, together with testing of pepsinogen I and II, is now widely used to stratify groups at high risk of gastric cancer in Japan. Those with a negative anti-
IgG titer, especially "high-negative" (3- |
| doi_str_mv | 10.1158/1055-9965.EPI-19-0993 |
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antibody, together with testing of pepsinogen I and II, is now widely used to stratify groups at high risk of gastric cancer in Japan. Those with a negative anti-
IgG titer, especially "high-negative" (3-<10 U/mL), are speculated to have higher risk of gastric cancer. We aimed to evaluate the association between a high-negative anti-
IgG titer and the long-term risk of gastric cancer in the Japan Public Health Center-based Prospective Study (JPHC Study) Cohort II.
The study population consisted of 19,106 Japanese men and women who were followed from 1993 to 2013. A Cox proportional hazards model was used to assess the risk of gastric cancer for plasma anti-
IgG titers, together with the severity of atrophic gastritis by pepsinogen I and II levels. A total of 595 cases of gastric cancer occurred during an average of 18 years of follow-up.
Compared with those with a low-negative anti-
IgG titer (≤3 U/mL), subjects with a high-negative titer (3-<10 U/mL) showed a significantly elevated risk of gastric cancer [HR = 2.81; 95% confidence interval (CI) = 1.62-4.89]. Among those with a high-negative titer, risk increase was observed under moderate or severe atrophic gastritis (HR = 18.73; 95% CI = 8.83-39.70).
Our results suggest that those with a high-negative anti-
IgG titer and moderate and severe atrophic gastritis are at increased long-term risk of gastric cancer.
Development of moderate or severe atrophic gastritis in subjects with high-negative anti-
IgG titer is suggested to increase risk of gastric cancer.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-19-0993</identifier><identifier>PMID: 31826914</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Antibodies, Bacterial - blood ; Antibodies, Bacterial - immunology ; Female ; Follow-Up Studies ; Gastritis, Atrophic - blood ; Gastritis, Atrophic - diagnosis ; Gastritis, Atrophic - microbiology ; Gastritis, Atrophic - pathology ; Helicobacter Infections - blood ; Helicobacter Infections - diagnosis ; Helicobacter Infections - microbiology ; Helicobacter Infections - pathology ; Helicobacter pylori - immunology ; Helicobacter pylori - isolation & purification ; Humans ; Immunoglobulin G - blood ; Immunoglobulin G - immunology ; Japan - epidemiology ; Male ; Middle Aged ; Pepsinogen A - blood ; Pepsinogen C - blood ; Prospective Studies ; Risk Assessment ; Serologic Tests ; Severity of Illness Index ; Stomach Neoplasms - epidemiology</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2020-02, Vol.29 (2), p.420-426</ispartof><rights>2019 American Association for Cancer Research.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-ea565ca73317832e18ab54398c1938aac5f69cd56ab60ab00bf68ae8f939dd003</citedby><cites>FETCH-LOGICAL-c375t-ea565ca73317832e18ab54398c1938aac5f69cd56ab60ab00bf68ae8f939dd003</cites><orcidid>0000-0001-6000-9830 ; 0000-0003-1276-2398 ; 0000-0002-9936-1476 ; 0000-0003-0669-654X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31826914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inoue, Manami</creatorcontrib><creatorcontrib>Sawada, Norie</creatorcontrib><creatorcontrib>Goto, Atsushi</creatorcontrib><creatorcontrib>Shimazu, Taichi</creatorcontrib><creatorcontrib>Yamaji, Taiki</creatorcontrib><creatorcontrib>Iwasaki, Motoki</creatorcontrib><creatorcontrib>Tsugane, Shoichiro</creatorcontrib><creatorcontrib>JPHC Study Group</creatorcontrib><title>High-Negative Anti- Helicobacter pylori IgG Antibody Titers and Long-Term Risk of Gastric Cancer: Results from a Large-Scale Population-Based Cohort Study in Japan</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Serologic testing of anti-
antibody, together with testing of pepsinogen I and II, is now widely used to stratify groups at high risk of gastric cancer in Japan. Those with a negative anti-
IgG titer, especially "high-negative" (3-<10 U/mL), are speculated to have higher risk of gastric cancer. We aimed to evaluate the association between a high-negative anti-
IgG titer and the long-term risk of gastric cancer in the Japan Public Health Center-based Prospective Study (JPHC Study) Cohort II.
The study population consisted of 19,106 Japanese men and women who were followed from 1993 to 2013. A Cox proportional hazards model was used to assess the risk of gastric cancer for plasma anti-
IgG titers, together with the severity of atrophic gastritis by pepsinogen I and II levels. A total of 595 cases of gastric cancer occurred during an average of 18 years of follow-up.
Compared with those with a low-negative anti-
IgG titer (≤3 U/mL), subjects with a high-negative titer (3-<10 U/mL) showed a significantly elevated risk of gastric cancer [HR = 2.81; 95% confidence interval (CI) = 1.62-4.89]. Among those with a high-negative titer, risk increase was observed under moderate or severe atrophic gastritis (HR = 18.73; 95% CI = 8.83-39.70).
Our results suggest that those with a high-negative anti-
IgG titer and moderate and severe atrophic gastritis are at increased long-term risk of gastric cancer.
Development of moderate or severe atrophic gastritis in subjects with high-negative anti-
IgG titer is suggested to increase risk of gastric cancer.</description><subject>Aged</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastritis, Atrophic - blood</subject><subject>Gastritis, Atrophic - diagnosis</subject><subject>Gastritis, Atrophic - microbiology</subject><subject>Gastritis, Atrophic - pathology</subject><subject>Helicobacter Infections - blood</subject><subject>Helicobacter Infections - diagnosis</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter Infections - pathology</subject><subject>Helicobacter pylori - immunology</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - immunology</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pepsinogen A - blood</subject><subject>Pepsinogen C - blood</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Serologic Tests</subject><subject>Severity of Illness Index</subject><subject>Stomach Neoplasms - epidemiology</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUFv1DAQhSMEoqXlJ4DmyMXFXq8Tm1tZtbuLVrRql7M1cSapIYmDnSDt7-kfJUtbTjPSvDdPel-WfRD8QgilPwuuFDMmVxdXt1smDOPGyFfZqVBSs6JQ6vW8v2hOsncp_eScF0apt9mJFHqRG7E8zR43vnlg36nB0f8huOxHz2BDrXehRDdShOHQhuhh26z_XctQHWDv50sC7CvYhb5he4od3Pn0C0INa0xj9A5W2DuKX-CO0tSOCeoYOkDYYWyI3TtsCW7DMLVzcujZV0xUwSo8hDjC_TjNKb6Hbzhgf569qbFN9P55nmU_rq_2qw3b3ay3q8sdc7JQIyNUuXJYSCkKLRckNJZqKY12wkiN6FSdG1epHMucY8l5WecaSddGmqriXJ5ln57-DjH8niiNtvPJUdtiT2FKdiEXSnJRFMtZqp6kLoaUItV2iL7DeLCC2yMfe-zeHru3Mx8rjD3ymX0fnyOmsqPqv-sFiPwLoByM-A</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Inoue, Manami</creator><creator>Sawada, Norie</creator><creator>Goto, Atsushi</creator><creator>Shimazu, Taichi</creator><creator>Yamaji, Taiki</creator><creator>Iwasaki, Motoki</creator><creator>Tsugane, Shoichiro</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6000-9830</orcidid><orcidid>https://orcid.org/0000-0003-1276-2398</orcidid><orcidid>https://orcid.org/0000-0002-9936-1476</orcidid><orcidid>https://orcid.org/0000-0003-0669-654X</orcidid></search><sort><creationdate>202002</creationdate><title>High-Negative Anti- Helicobacter pylori IgG Antibody Titers and Long-Term Risk of Gastric Cancer: Results from a Large-Scale Population-Based Cohort Study in Japan</title><author>Inoue, Manami ; Sawada, Norie ; Goto, Atsushi ; Shimazu, Taichi ; Yamaji, Taiki ; Iwasaki, Motoki ; Tsugane, Shoichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ea565ca73317832e18ab54398c1938aac5f69cd56ab60ab00bf68ae8f939dd003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastritis, Atrophic - blood</topic><topic>Gastritis, Atrophic - diagnosis</topic><topic>Gastritis, Atrophic - microbiology</topic><topic>Gastritis, Atrophic - pathology</topic><topic>Helicobacter Infections - blood</topic><topic>Helicobacter Infections - diagnosis</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter Infections - pathology</topic><topic>Helicobacter pylori - immunology</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - immunology</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pepsinogen A - blood</topic><topic>Pepsinogen C - blood</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Serologic Tests</topic><topic>Severity of Illness Index</topic><topic>Stomach Neoplasms - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inoue, Manami</creatorcontrib><creatorcontrib>Sawada, Norie</creatorcontrib><creatorcontrib>Goto, Atsushi</creatorcontrib><creatorcontrib>Shimazu, Taichi</creatorcontrib><creatorcontrib>Yamaji, Taiki</creatorcontrib><creatorcontrib>Iwasaki, Motoki</creatorcontrib><creatorcontrib>Tsugane, Shoichiro</creatorcontrib><creatorcontrib>JPHC Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inoue, Manami</au><au>Sawada, Norie</au><au>Goto, Atsushi</au><au>Shimazu, Taichi</au><au>Yamaji, Taiki</au><au>Iwasaki, Motoki</au><au>Tsugane, Shoichiro</au><aucorp>JPHC Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-Negative Anti- Helicobacter pylori IgG Antibody Titers and Long-Term Risk of Gastric Cancer: Results from a Large-Scale Population-Based Cohort Study in Japan</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2020-02</date><risdate>2020</risdate><volume>29</volume><issue>2</issue><spage>420</spage><epage>426</epage><pages>420-426</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Serologic testing of anti-
antibody, together with testing of pepsinogen I and II, is now widely used to stratify groups at high risk of gastric cancer in Japan. Those with a negative anti-
IgG titer, especially "high-negative" (3-<10 U/mL), are speculated to have higher risk of gastric cancer. We aimed to evaluate the association between a high-negative anti-
IgG titer and the long-term risk of gastric cancer in the Japan Public Health Center-based Prospective Study (JPHC Study) Cohort II.
The study population consisted of 19,106 Japanese men and women who were followed from 1993 to 2013. A Cox proportional hazards model was used to assess the risk of gastric cancer for plasma anti-
IgG titers, together with the severity of atrophic gastritis by pepsinogen I and II levels. A total of 595 cases of gastric cancer occurred during an average of 18 years of follow-up.
Compared with those with a low-negative anti-
IgG titer (≤3 U/mL), subjects with a high-negative titer (3-<10 U/mL) showed a significantly elevated risk of gastric cancer [HR = 2.81; 95% confidence interval (CI) = 1.62-4.89]. Among those with a high-negative titer, risk increase was observed under moderate or severe atrophic gastritis (HR = 18.73; 95% CI = 8.83-39.70).
Our results suggest that those with a high-negative anti-
IgG titer and moderate and severe atrophic gastritis are at increased long-term risk of gastric cancer.
Development of moderate or severe atrophic gastritis in subjects with high-negative anti-
IgG titer is suggested to increase risk of gastric cancer.</abstract><cop>United States</cop><pmid>31826914</pmid><doi>10.1158/1055-9965.EPI-19-0993</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6000-9830</orcidid><orcidid>https://orcid.org/0000-0003-1276-2398</orcidid><orcidid>https://orcid.org/0000-0002-9936-1476</orcidid><orcidid>https://orcid.org/0000-0003-0669-654X</orcidid></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Female Follow-Up Studies Gastritis, Atrophic - blood Gastritis, Atrophic - diagnosis Gastritis, Atrophic - microbiology Gastritis, Atrophic - pathology Helicobacter Infections - blood Helicobacter Infections - diagnosis Helicobacter Infections - microbiology Helicobacter Infections - pathology Helicobacter pylori - immunology Helicobacter pylori - isolation & purification Humans Immunoglobulin G - blood Immunoglobulin G - immunology Japan - epidemiology Male Middle Aged Pepsinogen A - blood Pepsinogen C - blood Prospective Studies Risk Assessment Serologic Tests Severity of Illness Index Stomach Neoplasms - epidemiology |
| title | High-Negative Anti- Helicobacter pylori IgG Antibody Titers and Long-Term Risk of Gastric Cancer: Results from a Large-Scale Population-Based Cohort Study in Japan |
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