Berberine attenuated the cytotoxicity induced by t-BHP via inhibiting oxidative stress and mitochondria dysfunction in PC-12 cells

Neurodegenerative diseases all share several common features such as involvement of oxidative damage and mitochondrial dysfunction in pathogenesis. Oxidative stress induced by overproduction of mitochondrial reactive oxygen species (ROS) or impairment of the antioxidant deficiency results in mitocho...

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Veröffentlicht in:	Cellular and molecular neurobiology 2020-05, Vol.40 (4), p.587-602
Hauptverfasser:	Li, Zhengmao, Jiang, Ting, Lu, Qi, Xu, Ke, He, Jianping, Xie, Lei, Chen, Zaifeng, Zheng, Zhilong, Ye, Luxia, Xu, Kebin, Zhang, Hongyu, Hu, Aiping
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Antioxidants Apoptosis Autophagy Bcl-2 protein Berberine Berberine - pharmacology Biomedical and Life Sciences Biomedicine Butyl hydroperoxide Cell Biology Cell death Cell Death - drug effects Chromones - pharmacology Cytochrome c Cytochromes c - metabolism Cytotoxicity L-Lactate dehydrogenase Lactic acid Lysosomes - drug effects Lysosomes - metabolism Membrane potential Membrane Potential, Mitochondrial - drug effects Microtubule-Associated Proteins - metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Mitophagy - drug effects Morpholines - pharmacology Neurobiology Neurodegenerative diseases Neurosciences Neurotoxicity Original Research Oxidation Oxidative stress Oxidative Stress - drug effects PC12 Cells Phagocytosis Phosphorylation Rats Reactive oxygen species Signal transduction Signal Transduction - drug effects tert-Butylhydroperoxide - toxicity TOR protein Traditional Chinese medicine
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