Alterations in mitochondrial functions and morphology in muscle and non‐muscle tissues in type 1 diabetes: implications for metabolic health
New Finding What is the topic of this review? Evidence of impaired mitochondrial functions and/or morphology in people with type 1 diabetes across various organ systems. What advances does it highlight? Impairments to mitochondrial functions and morphology may be a primary mechanism underlying the p...
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| Veröffentlicht in: | Experimental physiology 2020-04, Vol.105 (4), p.565-570 |
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| container_title | Experimental physiology |
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| creator | Monaco, Cynthia M.F. Perry, Christopher G.R. Hawke, Thomas J. |
| description | New Finding
What is the topic of this review?
Evidence of impaired mitochondrial functions and/or morphology in people with type 1 diabetes across various organ systems.
What advances does it highlight?
Impairments to mitochondrial functions and morphology may be a primary mechanism underlying the pathophysiology of various complications in people with type 1 diabetes.
We recently made the observation that there are significant alterations to the ultrastructure and functions of mitochondria in skeletal muscle of people with type 1 diabetes (T1D). These alterations are proposed to lead to decreased energy production in skeletal muscle during exercise and thus may contribute to the impaired aerobic exercise capacity reported in some people with T1D. This Symposium Review summarizes the evidence that similar alterations also occur in the mitochondria present in organ systems outside skeletal muscle in people with T1D, and that this may contribute to the development and progression of the known complications of T1D, which eventually lead to the reported premature mortality. |
| doi_str_mv | 10.1113/EP088096 |
| format | Article |
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What is the topic of this review?
Evidence of impaired mitochondrial functions and/or morphology in people with type 1 diabetes across various organ systems.
What advances does it highlight?
Impairments to mitochondrial functions and morphology may be a primary mechanism underlying the pathophysiology of various complications in people with type 1 diabetes.
We recently made the observation that there are significant alterations to the ultrastructure and functions of mitochondria in skeletal muscle of people with type 1 diabetes (T1D). These alterations are proposed to lead to decreased energy production in skeletal muscle during exercise and thus may contribute to the impaired aerobic exercise capacity reported in some people with T1D. This Symposium Review summarizes the evidence that similar alterations also occur in the mitochondria present in organ systems outside skeletal muscle in people with T1D, and that this may contribute to the development and progression of the known complications of T1D, which eventually lead to the reported premature mortality.</description><identifier>ISSN: 0958-0670</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/EP088096</identifier><identifier>PMID: 31826331</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Aerobic capacity ; bioenergetics ; Diabetes ; Diabetes mellitus (insulin dependent) ; Exercise ; IDDM ; insulin resistance ; insulin‐dependent diabetes mellitus ; Mitochondria ; Musculoskeletal system ; ROS ; Skeletal muscle ; T1D ; type 1 diabetes ; Ultrastructure ; unified theory</subject><ispartof>Experimental physiology, 2020-04, Vol.105 (4), p.565-570</ispartof><rights>2019 The Authors. Experimental Physiology © 2019 The Physiological Society</rights><rights>2019 The Authors. Experimental Physiology © 2019 The Physiological Society.</rights><rights>2020 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3847-56ac649d04cc6b64ed2c3e7f1581189a234c305ec04ed4ad0ff7046b5d6fba673</citedby><cites>FETCH-LOGICAL-c3847-56ac649d04cc6b64ed2c3e7f1581189a234c305ec04ed4ad0ff7046b5d6fba673</cites><orcidid>0000-0003-4974-4820</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2FEP088096$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2FEP088096$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31826331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monaco, Cynthia M.F.</creatorcontrib><creatorcontrib>Perry, Christopher G.R.</creatorcontrib><creatorcontrib>Hawke, Thomas J.</creatorcontrib><title>Alterations in mitochondrial functions and morphology in muscle and non‐muscle tissues in type 1 diabetes: implications for metabolic health</title><title>Experimental physiology</title><addtitle>Exp Physiol</addtitle><description>New Finding
What is the topic of this review?
Evidence of impaired mitochondrial functions and/or morphology in people with type 1 diabetes across various organ systems.
What advances does it highlight?
Impairments to mitochondrial functions and morphology may be a primary mechanism underlying the pathophysiology of various complications in people with type 1 diabetes.
We recently made the observation that there are significant alterations to the ultrastructure and functions of mitochondria in skeletal muscle of people with type 1 diabetes (T1D). These alterations are proposed to lead to decreased energy production in skeletal muscle during exercise and thus may contribute to the impaired aerobic exercise capacity reported in some people with T1D. This Symposium Review summarizes the evidence that similar alterations also occur in the mitochondria present in organ systems outside skeletal muscle in people with T1D, and that this may contribute to the development and progression of the known complications of T1D, which eventually lead to the reported premature mortality.</description><subject>Aerobic capacity</subject><subject>bioenergetics</subject><subject>Diabetes</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Exercise</subject><subject>IDDM</subject><subject>insulin resistance</subject><subject>insulin‐dependent diabetes mellitus</subject><subject>Mitochondria</subject><subject>Musculoskeletal system</subject><subject>ROS</subject><subject>Skeletal muscle</subject><subject>T1D</subject><subject>type 1 diabetes</subject><subject>Ultrastructure</subject><subject>unified theory</subject><issn>0958-0670</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kc9KHTEUh0NR6tUW-gQS6MbNaDL5M5nuRKwKgl200N2QyZzpjWSSaZJB7s4nEJ-xT-J471Wh4CqH8_v4cuCH0BdKjiml7OT8B1GK1PIDWlAu64Jz8XsHLUgtVEFkRfbQfkq3hFBGFP-I9hhVpWSMLtDDqcsQdbbBJ2w9HmwOZhl8F612uJ-82UTad3gIcVwGF_6s1uSUjIN14IP_d_-4XWSb0gRrWV6NgCnurG4hQ_qG7TA6a7a_9SHiAbJuw7zDS9AuLz-h3V67BJ-37wH69f3859llcX1zcXV2el0YpnhVCKmN5HVHuDGylRy60jCoeioUparWJeOGEQGGzBHXHen7inDZik72rZYVO0BHG-8Yw9_52twMNhlwTnsIU2pKVoqyVrR-Rr_-h96GKfr5uplSlSBSUv4mNDGkFKFvxmgHHVcNJc1zR81LRzN6uBVO7QDdK_hSygwcb4A762D1rmgeLmkpRcWeAHEfnK0</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Monaco, Cynthia M.F.</creator><creator>Perry, Christopher G.R.</creator><creator>Hawke, Thomas J.</creator><general>John Wiley & Sons, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4974-4820</orcidid></search><sort><creationdate>20200401</creationdate><title>Alterations in mitochondrial functions and morphology in muscle and non‐muscle tissues in type 1 diabetes: implications for metabolic health</title><author>Monaco, Cynthia M.F. ; Perry, Christopher G.R. ; Hawke, Thomas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3847-56ac649d04cc6b64ed2c3e7f1581189a234c305ec04ed4ad0ff7046b5d6fba673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aerobic capacity</topic><topic>bioenergetics</topic><topic>Diabetes</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Exercise</topic><topic>IDDM</topic><topic>insulin resistance</topic><topic>insulin‐dependent diabetes mellitus</topic><topic>Mitochondria</topic><topic>Musculoskeletal system</topic><topic>ROS</topic><topic>Skeletal muscle</topic><topic>T1D</topic><topic>type 1 diabetes</topic><topic>Ultrastructure</topic><topic>unified theory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monaco, Cynthia M.F.</creatorcontrib><creatorcontrib>Perry, Christopher G.R.</creatorcontrib><creatorcontrib>Hawke, Thomas J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monaco, Cynthia M.F.</au><au>Perry, Christopher G.R.</au><au>Hawke, Thomas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in mitochondrial functions and morphology in muscle and non‐muscle tissues in type 1 diabetes: implications for metabolic health</atitle><jtitle>Experimental physiology</jtitle><addtitle>Exp Physiol</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>105</volume><issue>4</issue><spage>565</spage><epage>570</epage><pages>565-570</pages><issn>0958-0670</issn><eissn>1469-445X</eissn><abstract>New Finding
What is the topic of this review?
Evidence of impaired mitochondrial functions and/or morphology in people with type 1 diabetes across various organ systems.
What advances does it highlight?
Impairments to mitochondrial functions and morphology may be a primary mechanism underlying the pathophysiology of various complications in people with type 1 diabetes.
We recently made the observation that there are significant alterations to the ultrastructure and functions of mitochondria in skeletal muscle of people with type 1 diabetes (T1D). These alterations are proposed to lead to decreased energy production in skeletal muscle during exercise and thus may contribute to the impaired aerobic exercise capacity reported in some people with T1D. This Symposium Review summarizes the evidence that similar alterations also occur in the mitochondria present in organ systems outside skeletal muscle in people with T1D, and that this may contribute to the development and progression of the known complications of T1D, which eventually lead to the reported premature mortality.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>31826331</pmid><doi>10.1113/EP088096</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4974-4820</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental physiology, 2020-04, Vol.105 (4), p.565-570 |
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| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; Wiley Online Library Free Content |
| subjects | Aerobic capacity bioenergetics Diabetes Diabetes mellitus (insulin dependent) Exercise IDDM insulin resistance insulin‐dependent diabetes mellitus Mitochondria Musculoskeletal system ROS Skeletal muscle T1D type 1 diabetes Ultrastructure unified theory |
| title | Alterations in mitochondrial functions and morphology in muscle and non‐muscle tissues in type 1 diabetes: implications for metabolic health |
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