Purinergic signalling selectively modulates maintenance but not repair neurogenesis in the zebrafish olfactory epithelium

Olfactory sensory neurons (OSNs) of the vertebrate olfactory epithelium (OE) undergo continuous turnover but also regenerate efficiently when the OE is acutely damaged by traumatic injury. Two distinct pools of neuronal stem/progenitor cells, the globose (GBCs), and horizontal basal cells (HBCs) hav...

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Veröffentlicht in:	The FEBS journal 2020-07, Vol.287 (13), p.2699-2722
Hauptverfasser:	Demirler, Mehmet Can, Sakizli, Uğurcan, Bali, Burak, Kocagöz, Yiğit, Eski, Sema Elif, Ergönen, Arda, Alkiraz, Aysu Sevval, Bayramli, Xalid, Hassenklöver, Thomas, Manzini, Ivan, Fuss, Stefan H.
Format:	Artikel
Sprache:	eng
Schlagworte:	adult neurogenesis Animals Basal cells Calcium - metabolism Calcium ions Calcium signalling Cell Differentiation Cell Proliferation Damage Danio rerio Epithelium Horizontal cells Keratin Markers Neural stem cells Neural Stem Cells - drug effects Neural Stem Cells - metabolism Neurogenesis Neuronal-glial interactions Neurons Olfactory epithelium Olfactory Mucosa - drug effects Olfactory Mucosa - metabolism Olfactory receptor neurons Olfactory Receptor Neurons - drug effects Olfactory Receptor Neurons - metabolism Progenitor cells purine signaling Purines - pharmacology Receptors, Purinergic - metabolism Regeneration Sensory neurons Signal Transduction Signaling SOXB1 Transcription Factors - metabolism Stem cells Stimulation Vertebrates Zebrafish
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