Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective
Stimulator of interferon genes (STING) is an adaptor protein that induces the secretion of type I interferons and proinflammatory cytokines and is triggered by cytosolic DNA of pathogen and host origins. Given that STING is a mediator in the immune system, pharmacological modulation of STING has sho...
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| Veröffentlicht in: | Journal of medicinal chemistry 2020-04, Vol.63 (8), p.3785-3816 |
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| container_title | Journal of medicinal chemistry |
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| creator | Zhang, Han You, Qi-Dong Xu, Xiao-Li |
| description | Stimulator of interferon genes (STING) is an adaptor protein that induces the secretion of type I interferons and proinflammatory cytokines and is triggered by cytosolic DNA of pathogen and host origins. Given that STING is a mediator in the immune system, pharmacological modulation of STING has shown viable therapeutic effects for pathogen infection, cancer, and inflammatory diseases. In the past decade, the substantial development in this field has encouraged the discovery of STING modulators. Here, we will summarize the current understanding of STING structure, survey the status quo of STING modulators, compare established bioassay methods, review the chemical structures and bioactivities of agonists and inhibitors, and propose suggestions and insights for the future exploitation of STING modulators. |
| doi_str_mv | 10.1021/acs.jmedchem.9b01039 |
| format | Article |
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Given that STING is a mediator in the immune system, pharmacological modulation of STING has shown viable therapeutic effects for pathogen infection, cancer, and inflammatory diseases. In the past decade, the substantial development in this field has encouraged the discovery of STING modulators. 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Med. Chem</addtitle><description>Stimulator of interferon genes (STING) is an adaptor protein that induces the secretion of type I interferons and proinflammatory cytokines and is triggered by cytosolic DNA of pathogen and host origins. Given that STING is a mediator in the immune system, pharmacological modulation of STING has shown viable therapeutic effects for pathogen infection, cancer, and inflammatory diseases. In the past decade, the substantial development in this field has encouraged the discovery of STING modulators. 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Med. Chem</addtitle><date>2020-04-23</date><risdate>2020</risdate><volume>63</volume><issue>8</issue><spage>3785</spage><epage>3816</epage><pages>3785-3816</pages><issn>0022-2623</issn><eissn>1520-4804</eissn><abstract>Stimulator of interferon genes (STING) is an adaptor protein that induces the secretion of type I interferons and proinflammatory cytokines and is triggered by cytosolic DNA of pathogen and host origins. Given that STING is a mediator in the immune system, pharmacological modulation of STING has shown viable therapeutic effects for pathogen infection, cancer, and inflammatory diseases. In the past decade, the substantial development in this field has encouraged the discovery of STING modulators. 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| ispartof | Journal of medicinal chemistry, 2020-04, Vol.63 (8), p.3785-3816 |
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| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - metabolism Antineoplastic Agents - administration & dosage Antineoplastic Agents - metabolism Autoimmune Diseases - drug therapy Autoimmune Diseases - metabolism Binding Sites - drug effects Binding Sites - physiology Chemistry, Pharmaceutical - methods Drug Delivery Systems - methods Humans Membrane Proteins - agonists Membrane Proteins - antagonists & inhibitors Membrane Proteins - chemistry Membrane Proteins - metabolism Neoplasms - drug therapy Neoplasms - metabolism Protein Structure, Secondary Signal Transduction - drug effects Signal Transduction - physiology |
| title | Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective |
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