Facile and scalable synthesis of topologically nanoengineered polypeptides with excellent antimicrobial activities
A facile and scalable strategy for the quick library synthesis of linear-, hinged-, star-, and cyclic-polypeptides with broad-spectrum antimicrobial activity has been reported. The topologically nanoengineered polypeptides show superior antimicrobial activity against Gram-positive and Gram-negative...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-01, Vol.56 (3), p.356-359 |
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| container_issue | 3 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 56 |
| creator | Zhang, Yu Song, Wenliang Li, Shuwei Kim, Dae-Kyoung Kim, Jae Ho Kim, Jung Rae Kim, Il |
| description | A facile and scalable strategy for the quick library synthesis of linear-, hinged-, star-, and cyclic-polypeptides with broad-spectrum antimicrobial activity has been reported. The topologically nanoengineered polypeptides show superior antimicrobial activity against Gram-positive and Gram-negative bacteria and low toxicity, allowing screening of architectural polypeptides as mimics of host defense peptides for antimicrobials.
A facile and scalable strategy for the quick library synthesis of linear-, hinged-, star-, and cyclic-polypeptides with broad-spectrum antimicrobial activity has been reported. |
| doi_str_mv | 10.1039/c9cc08095c |
| format | Article |
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Song, Wenliang ; Li, Shuwei ; Kim, Dae-Kyoung ; Kim, Jae Ho ; Kim, Jung Rae ; Kim, Il</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-951f3f5b69c51775e8e0512956b8106b1ffc20e4a7ac3b17c60c7c7f10da63fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Anti-Infective Agents - chemical synthesis</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Cell Survival - drug effects</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Microscopy, Confocal</topic><topic>Nanotechnology</topic><topic>NIH 3T3 Cells</topic><topic>Peptides</topic><topic>Peptides - chemical synthesis</topic><topic>Peptides - chemistry</topic><topic>Peptides - pharmacology</topic><topic>Polypeptides</topic><topic>Synthesis</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Song, Wenliang</creatorcontrib><creatorcontrib>Li, Shuwei</creatorcontrib><creatorcontrib>Kim, Dae-Kyoung</creatorcontrib><creatorcontrib>Kim, Jae Ho</creatorcontrib><creatorcontrib>Kim, Jung Rae</creatorcontrib><creatorcontrib>Kim, Il</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yu</au><au>Song, Wenliang</au><au>Li, Shuwei</au><au>Kim, Dae-Kyoung</au><au>Kim, Jae Ho</au><au>Kim, Jung Rae</au><au>Kim, Il</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Facile and scalable synthesis of topologically nanoengineered polypeptides with excellent antimicrobial activities</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2020-01-02</date><risdate>2020</risdate><volume>56</volume><issue>3</issue><spage>356</spage><epage>359</epage><pages>356-359</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>A facile and scalable strategy for the quick library synthesis of linear-, hinged-, star-, and cyclic-polypeptides with broad-spectrum antimicrobial activity has been reported. The topologically nanoengineered polypeptides show superior antimicrobial activity against Gram-positive and Gram-negative bacteria and low toxicity, allowing screening of architectural polypeptides as mimics of host defense peptides for antimicrobials.
A facile and scalable strategy for the quick library synthesis of linear-, hinged-, star-, and cyclic-polypeptides with broad-spectrum antimicrobial activity has been reported.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>31825398</pmid><doi>10.1039/c9cc08095c</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-0103-7457</orcidid><orcidid>https://orcid.org/0000-0001-8047-7543</orcidid><orcidid>https://orcid.org/0000-0002-8005-5460</orcidid></addata></record> |
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| ispartof | Chemical communications (Cambridge, England), 2020-01, Vol.56 (3), p.356-359 |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antiinfectives and antibacterials Antimicrobial agents Cell Survival - drug effects Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Mice Microbial Sensitivity Tests Microscopy, Confocal Nanotechnology NIH 3T3 Cells Peptides Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology Polypeptides Synthesis Toxicity |
| title | Facile and scalable synthesis of topologically nanoengineered polypeptides with excellent antimicrobial activities |
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