Comparative Effectiveness of Combined Favipiravir and Oseltamivir Therapy Versus Oseltamivir Monotherapy in Critically Ill Patients With Influenza Virus Infection

Abstract Background A synergistic effect of combination therapy with favipiravir and oseltamivir has been reported in preclinical models of influenza. However, no data are available on the clinical effectiveness of combination therapy in severe influenza. Methods Data from 2 separate prospective stu...

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Veröffentlicht in:	The Journal of infectious diseases 2020-04, Vol.221 (10), p.1688-1698
Hauptverfasser:	Wang, Yeming, Fan, Guohui, Salam, Alex, Horby, Peter, Hayden, Frederick G, Chen, Cheng, Pan, Jianguang, Zheng, Jing, Lu, Binghuai, Guo, Liping, Wang, Chen, Cao, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amides - administration & dosage Amides - therapeutic use Antiviral Agents - administration & dosage Antiviral Agents - therapeutic use Antiviral drugs Critical care Critical Illness Drug Therapy, Combination Female Humans Influenza Influenza, Human - drug therapy Male Middle Aged Oseltamivir Oseltamivir - administration & dosage Oseltamivir - therapeutic use Pyrazines - administration & dosage Pyrazines - therapeutic use Retrospective Studies Ribonucleic acid RNA Viral infections
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