The effect of colonoscopy on intraocular pressure: an observational prospective study
Purpose Colonoscopy is an endoscopic examination of the bowel. It requires insufflation of the large bowel lumen with gas which leads to intraabdominal hypertension (IAH). There is evidence suggesting that IAH positively correlates with intracranial pressure (ICP) and possibly with intraocular press...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2020-03, Vol.258 (3), p.607-611 |
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| creator | Kent, Ilan Geffen, Noa Stein, Assaf Rudnicki, Yaron Friehmann, Asaf Avital, Shmuel |
| description | Purpose
Colonoscopy is an endoscopic examination of the bowel. It requires insufflation of the large bowel lumen with gas which leads to intraabdominal hypertension (IAH). There is evidence suggesting that IAH positively correlates with intracranial pressure (ICP) and possibly with intraocular pressure (IOP). The aim of this study was to examine the effect of routine screening colonoscopy performed under sedation on the IOP in healthy individuals.
Patients and methods
This was a prospective, single site, observational study. Healthy adults undergoing routine colonoscopy performed under sedation including propofol, fentanyl, and midazolam were recruited. Right eye IOP measurements were performed using Tonopen XL® in a left decubitus position at 5 time points during the procedure. Statistical analysis was performed using Student’s t-test for paired samples.
Results
Twenty-three Caucasians were recruited. There are 14 males (60%) with a mean age of 60.4 ± 10.4 years (range 36–74). Colonoscopy was conducted under sedation and completed in 22 subjects. Mean baseline IOP was 19.9 ± 4.7 mmHg, 15.8 ± 4.8 mmHg immediately after sedation, 13.5 ± 2.3 mmHg when the colonoscope had reached the cecum, 15.4 ± 5.0 mmHg 5 min after colonoscopy beginning, and 16.5 ± 5.5 mmHg when located in the rectum. The IOP reduction during the procedure was statistically significant (
P
< 0.01).
Conclusion
Routine colonoscopy performed under sedation using propofol, fentanyl, and midazolam does not increase the IOP in healthy adults. |
| doi_str_mv | 10.1007/s00417-019-04542-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2324910349</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2324910349</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-3a99c4b36509cd49d5f36b3ad54e205bcf2c1a3c9e35a0eafade14c083104dd63</originalsourceid><addsrcrecordid>eNqNkU1LHTEUhkNR6q3tH-hCAm4KZezJ18ykO7n0C4RuFNyFTOakjsxNbpMZ5f77RscquBBXCeR5X855QshHBicMoPmSASRrKmC6Aqkkr9QbsmJSqKoBfrlHVtBwVrWCXx6QdzlfQ-GFYm_JgWAtF1DzFbk4v0KK3qObaPTUxTGGmF3c7mgMdAhTstHNo010mzDnOeFXagONXcZ0Y6chBjuWp5i3pWG4QZqnud-9J_vejhk_PJyH5OL7t_P1z-rs949f69OzyolGTZWwWjvZiVqBdr3UvfKi7oTtlUQOqnOeO2aF0yiUBbTe9sikg1YwkH1fi0PyaektE_ydMU9mM2SH42gDxjkbLrjUDITUBT1-hl7HOZXp7yhVt6AaDYXiC-XKSjmhN9s0bGzaGQbmTrpZpJsi3dxLN6qEjh6q526D_WPkv-UCtAtwi1302Q0YHD5i5VsUky1IWW6sXg_Tvdd1nMNUop9fHy20WOhciPAH09OSL8z_D826rk4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2356805790</pqid></control><display><type>article</type><title>The effect of colonoscopy on intraocular pressure: an observational prospective study</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Kent, Ilan ; Geffen, Noa ; Stein, Assaf ; Rudnicki, Yaron ; Friehmann, Asaf ; Avital, Shmuel</creator><creatorcontrib>Kent, Ilan ; Geffen, Noa ; Stein, Assaf ; Rudnicki, Yaron ; Friehmann, Asaf ; Avital, Shmuel</creatorcontrib><description>Purpose
Colonoscopy is an endoscopic examination of the bowel. It requires insufflation of the large bowel lumen with gas which leads to intraabdominal hypertension (IAH). There is evidence suggesting that IAH positively correlates with intracranial pressure (ICP) and possibly with intraocular pressure (IOP). The aim of this study was to examine the effect of routine screening colonoscopy performed under sedation on the IOP in healthy individuals.
Patients and methods
This was a prospective, single site, observational study. Healthy adults undergoing routine colonoscopy performed under sedation including propofol, fentanyl, and midazolam were recruited. Right eye IOP measurements were performed using Tonopen XL® in a left decubitus position at 5 time points during the procedure. Statistical analysis was performed using Student’s t-test for paired samples.
Results
Twenty-three Caucasians were recruited. There are 14 males (60%) with a mean age of 60.4 ± 10.4 years (range 36–74). Colonoscopy was conducted under sedation and completed in 22 subjects. Mean baseline IOP was 19.9 ± 4.7 mmHg, 15.8 ± 4.8 mmHg immediately after sedation, 13.5 ± 2.3 mmHg when the colonoscope had reached the cecum, 15.4 ± 5.0 mmHg 5 min after colonoscopy beginning, and 16.5 ± 5.5 mmHg when located in the rectum. The IOP reduction during the procedure was statistically significant (
P
< 0.01).
Conclusion
Routine colonoscopy performed under sedation using propofol, fentanyl, and midazolam does not increase the IOP in healthy adults.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-019-04542-5</identifier><identifier>PMID: 31823062</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdomen - physiopathology ; Adult ; Aged ; Anesthesia ; Cecum ; Colon ; Colonoscopy ; Female ; Fentanyl ; Glaucoma ; Humans ; Intestine ; Intraocular Pressure - physiology ; Life Sciences & Biomedicine ; Male ; Medicine ; Medicine & Public Health ; Midazolam ; Middle Aged ; Ophthalmology ; Pressure ; Propofol ; Prospective Studies ; Rectum ; Science & Technology ; Statistical analysis ; Tonometry, Ocular</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2020-03, Vol.258 (3), p.607-611</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Graefe's Archive for Clinical and Experimental Ophthalmology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000514804400016</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c375t-3a99c4b36509cd49d5f36b3ad54e205bcf2c1a3c9e35a0eafade14c083104dd63</citedby><cites>FETCH-LOGICAL-c375t-3a99c4b36509cd49d5f36b3ad54e205bcf2c1a3c9e35a0eafade14c083104dd63</cites><orcidid>0000-0001-7886-0092</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-019-04542-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-019-04542-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,28253,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31823062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kent, Ilan</creatorcontrib><creatorcontrib>Geffen, Noa</creatorcontrib><creatorcontrib>Stein, Assaf</creatorcontrib><creatorcontrib>Rudnicki, Yaron</creatorcontrib><creatorcontrib>Friehmann, Asaf</creatorcontrib><creatorcontrib>Avital, Shmuel</creatorcontrib><title>The effect of colonoscopy on intraocular pressure: an observational prospective study</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>GRAEF ARCH CLIN EXP</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
Colonoscopy is an endoscopic examination of the bowel. It requires insufflation of the large bowel lumen with gas which leads to intraabdominal hypertension (IAH). There is evidence suggesting that IAH positively correlates with intracranial pressure (ICP) and possibly with intraocular pressure (IOP). The aim of this study was to examine the effect of routine screening colonoscopy performed under sedation on the IOP in healthy individuals.
Patients and methods
This was a prospective, single site, observational study. Healthy adults undergoing routine colonoscopy performed under sedation including propofol, fentanyl, and midazolam were recruited. Right eye IOP measurements were performed using Tonopen XL® in a left decubitus position at 5 time points during the procedure. Statistical analysis was performed using Student’s t-test for paired samples.
Results
Twenty-three Caucasians were recruited. There are 14 males (60%) with a mean age of 60.4 ± 10.4 years (range 36–74). Colonoscopy was conducted under sedation and completed in 22 subjects. Mean baseline IOP was 19.9 ± 4.7 mmHg, 15.8 ± 4.8 mmHg immediately after sedation, 13.5 ± 2.3 mmHg when the colonoscope had reached the cecum, 15.4 ± 5.0 mmHg 5 min after colonoscopy beginning, and 16.5 ± 5.5 mmHg when located in the rectum. The IOP reduction during the procedure was statistically significant (
P
< 0.01).
Conclusion
Routine colonoscopy performed under sedation using propofol, fentanyl, and midazolam does not increase the IOP in healthy adults.</description><subject>Abdomen - physiopathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia</subject><subject>Cecum</subject><subject>Colon</subject><subject>Colonoscopy</subject><subject>Female</subject><subject>Fentanyl</subject><subject>Glaucoma</subject><subject>Humans</subject><subject>Intestine</subject><subject>Intraocular Pressure - physiology</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Midazolam</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Pressure</subject><subject>Propofol</subject><subject>Prospective Studies</subject><subject>Rectum</subject><subject>Science & Technology</subject><subject>Statistical analysis</subject><subject>Tonometry, Ocular</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1LHTEUhkNR6q3tH-hCAm4KZezJ18ykO7n0C4RuFNyFTOakjsxNbpMZ5f77RscquBBXCeR5X855QshHBicMoPmSASRrKmC6Aqkkr9QbsmJSqKoBfrlHVtBwVrWCXx6QdzlfQ-GFYm_JgWAtF1DzFbk4v0KK3qObaPTUxTGGmF3c7mgMdAhTstHNo010mzDnOeFXagONXcZ0Y6chBjuWp5i3pWG4QZqnud-9J_vejhk_PJyH5OL7t_P1z-rs949f69OzyolGTZWwWjvZiVqBdr3UvfKi7oTtlUQOqnOeO2aF0yiUBbTe9sikg1YwkH1fi0PyaektE_ydMU9mM2SH42gDxjkbLrjUDITUBT1-hl7HOZXp7yhVt6AaDYXiC-XKSjmhN9s0bGzaGQbmTrpZpJsi3dxLN6qEjh6q526D_WPkv-UCtAtwi1302Q0YHD5i5VsUky1IWW6sXg_Tvdd1nMNUop9fHy20WOhciPAH09OSL8z_D826rk4</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Kent, Ilan</creator><creator>Geffen, Noa</creator><creator>Stein, Assaf</creator><creator>Rudnicki, Yaron</creator><creator>Friehmann, Asaf</creator><creator>Avital, Shmuel</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7886-0092</orcidid></search><sort><creationdate>20200301</creationdate><title>The effect of colonoscopy on intraocular pressure: an observational prospective study</title><author>Kent, Ilan ; Geffen, Noa ; Stein, Assaf ; Rudnicki, Yaron ; Friehmann, Asaf ; Avital, Shmuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-3a99c4b36509cd49d5f36b3ad54e205bcf2c1a3c9e35a0eafade14c083104dd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdomen - physiopathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia</topic><topic>Cecum</topic><topic>Colon</topic><topic>Colonoscopy</topic><topic>Female</topic><topic>Fentanyl</topic><topic>Glaucoma</topic><topic>Humans</topic><topic>Intestine</topic><topic>Intraocular Pressure - physiology</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Midazolam</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Pressure</topic><topic>Propofol</topic><topic>Prospective Studies</topic><topic>Rectum</topic><topic>Science & Technology</topic><topic>Statistical analysis</topic><topic>Tonometry, Ocular</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kent, Ilan</creatorcontrib><creatorcontrib>Geffen, Noa</creatorcontrib><creatorcontrib>Stein, Assaf</creatorcontrib><creatorcontrib>Rudnicki, Yaron</creatorcontrib><creatorcontrib>Friehmann, Asaf</creatorcontrib><creatorcontrib>Avital, Shmuel</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kent, Ilan</au><au>Geffen, Noa</au><au>Stein, Assaf</au><au>Rudnicki, Yaron</au><au>Friehmann, Asaf</au><au>Avital, Shmuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of colonoscopy on intraocular pressure: an observational prospective study</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><stitle>GRAEF ARCH CLIN EXP</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>258</volume><issue>3</issue><spage>607</spage><epage>611</epage><pages>607-611</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
Colonoscopy is an endoscopic examination of the bowel. It requires insufflation of the large bowel lumen with gas which leads to intraabdominal hypertension (IAH). There is evidence suggesting that IAH positively correlates with intracranial pressure (ICP) and possibly with intraocular pressure (IOP). The aim of this study was to examine the effect of routine screening colonoscopy performed under sedation on the IOP in healthy individuals.
Patients and methods
This was a prospective, single site, observational study. Healthy adults undergoing routine colonoscopy performed under sedation including propofol, fentanyl, and midazolam were recruited. Right eye IOP measurements were performed using Tonopen XL® in a left decubitus position at 5 time points during the procedure. Statistical analysis was performed using Student’s t-test for paired samples.
Results
Twenty-three Caucasians were recruited. There are 14 males (60%) with a mean age of 60.4 ± 10.4 years (range 36–74). Colonoscopy was conducted under sedation and completed in 22 subjects. Mean baseline IOP was 19.9 ± 4.7 mmHg, 15.8 ± 4.8 mmHg immediately after sedation, 13.5 ± 2.3 mmHg when the colonoscope had reached the cecum, 15.4 ± 5.0 mmHg 5 min after colonoscopy beginning, and 16.5 ± 5.5 mmHg when located in the rectum. The IOP reduction during the procedure was statistically significant (
P
< 0.01).
Conclusion
Routine colonoscopy performed under sedation using propofol, fentanyl, and midazolam does not increase the IOP in healthy adults.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31823062</pmid><doi>10.1007/s00417-019-04542-5</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-7886-0092</orcidid></addata></record> |
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| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2020-03, Vol.258 (3), p.607-611 |
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| source | MEDLINE; SpringerNature Journals; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Abdomen - physiopathology Adult Aged Anesthesia Cecum Colon Colonoscopy Female Fentanyl Glaucoma Humans Intestine Intraocular Pressure - physiology Life Sciences & Biomedicine Male Medicine Medicine & Public Health Midazolam Middle Aged Ophthalmology Pressure Propofol Prospective Studies Rectum Science & Technology Statistical analysis Tonometry, Ocular |
| title | The effect of colonoscopy on intraocular pressure: an observational prospective study |
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