Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

NLRP3-inflammasome-driven inflammation is involved in the pathogenesis of a variety of diseases. Identification of endogenous inflammasome activators is essential for the development of new anti-inflammatory treatment strategies. Here, we identified that apolipoprotein C3 (ApoC3) activates the NLRP3...

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Veröffentlicht in:	Nature immunology 2020-01, Vol.21 (1), p.30-41
Hauptverfasser:	Zewinger, Stephen, Reiser, Jochen, Jankowski, Vera, Alansary, Dalia, Hahm, Eunsil, Triem, Sarah, Klug, Mira, Schunk, Stefan J., Schmit, David, Kramann, Rafael, Körbel, Christina, Ampofo, Emmanuel, Laschke, Matthias W., Selejan, Simina-Ramona, Paschen, Anna, Herter, Tobias, Schuster, Susanne, Silbernagel, Günther, Sester, Martina, Sester, Urban, Aßmann, Gunter, Bals, Robert, Kostner, Gerhard, Jahnen-Dechent, Willi, Menger, Michael D., Rohrer, Lucia, März, Winfried, Böhm, Michael, Jankowski, Joachim, Kopf, Manfred, Latz, Eicke, Niemeyer, Barbara A., Fliser, Danilo, Laufs, Ulrich, Speer, Thimoteus
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2504/342 631/250/256/2177 631/250/262/2106/2517 Acute Kidney Injury - immunology Acute Kidney Injury - pathology Adapter proteins Adaptor Proteins, Signal Transducing Analysis Animal models Animals Apolipoprotein C-III - genetics Apolipoprotein C-III - immunology Apolipoproteins Arteriosclerosis Atherosclerosis Biomedical and Life Sciences Biomedicine Blood lipids Caspase 8 - metabolism Caspase-8 Cell activation Cell Line Computer software industry Development and progression Dimerization Disease Models, Animal HEK293 Cells Humans Immunology Infectious Diseases Inflammasomes Inflammasomes - immunology Inflammation Inflammation - genetics Inflammation - immunology Kidney diseases Kidney Diseases - immunology Kidney Diseases - pathology Kidneys Lipoproteins Lyn protein Medical colleges Membrane Proteins Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Knockout Monocytes Monocytes - immunology NLR Family, Pyrin Domain-Containing 3 Protein - immunology Reactive oxygen species Reactive Oxygen Species - metabolism Scientific equipment and supplies industry Syk protein Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - metabolism Toll-like receptors
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