Epigenome editing by CRISPR/Cas9 in clinical settings: possibilities and challenges
Epigenome editing is a promising approach for both basic research and clinical application. With the convergence of techniques from different fields, regulating gene expression artificially becomes possible. From a clinical point of view, targeted epigenome editing by CRISPR/Cas9 of disease-related...
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| Veröffentlicht in: | Briefings in functional genomics 2020-05, Vol.19 (3), p.215-228 |
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| container_title | Briefings in functional genomics |
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| creator | Pei, Wen-Di Zhang, Yan Yin, Tai-Lang Yu, Yang |
| description | Epigenome editing is a promising approach for both basic research and clinical application. With the convergence of techniques from different fields, regulating gene expression artificially becomes possible. From a clinical point of view, targeted epigenome editing by CRISPR/Cas9 of disease-related genes offers novel therapeutic avenues for many diseases. In this review, we summarize the EpiEffectors used in epigenome editing by CRISPR/Cas9, current applications of epigenome editing and progress made in this field. Moreover, application challenges such as off-target effects, inefficient delivery, stability and immunogenicity are discussed. In conclusion, epigenome editing by CRISPR/Cas9 has broad prospects in the clinic, and future work will promote the application of this technology. |
| doi_str_mv | 10.1093/bfgp/elz035 |
| format | Article |
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With the convergence of techniques from different fields, regulating gene expression artificially becomes possible. From a clinical point of view, targeted epigenome editing by CRISPR/Cas9 of disease-related genes offers novel therapeutic avenues for many diseases. In this review, we summarize the EpiEffectors used in epigenome editing by CRISPR/Cas9, current applications of epigenome editing and progress made in this field. Moreover, application challenges such as off-target effects, inefficient delivery, stability and immunogenicity are discussed. In conclusion, epigenome editing by CRISPR/Cas9 has broad prospects in the clinic, and future work will promote the application of this technology.</description><identifier>ISSN: 2041-2657</identifier><identifier>EISSN: 2041-2657</identifier><identifier>DOI: 10.1093/bfgp/elz035</identifier><identifier>PMID: 31819946</identifier><language>eng</language><publisher>England</publisher><ispartof>Briefings in functional genomics, 2020-05, Vol.19 (3), p.215-228</ispartof><rights>The Author(s) 2019. Published by Oxford University Press. All rights reserved. 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| title | Epigenome editing by CRISPR/Cas9 in clinical settings: possibilities and challenges |
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