An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase
A combinatorial approach using a one-bead-one-compound method and a screening based on a SOD-activity assay was set up for the discovery of an efficient peptidyl copper complex. The complex exhibited good stability constants, suitable redox potentials and excellent intrinsic activity. This complex w...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-01, Vol.56 (3), p.399-42 |
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| creator | Vincent, Amandine Fores, Jennifer Rodon Tauziet, Elodie Quévrain, Elodie Dancs, Ágnes Conte-Daban, Amandine Bernard, Anne-Sophie Pelupessy, Philippe Coulibaly, Koudedja Seksik, Philippe Hureau, Christelle Selmeczi, Katalin Policar, Clotilde Delsuc, Nicolas |
| description | A combinatorial approach using a one-bead-one-compound method and a screening based on a SOD-activity assay was set up for the discovery of an efficient peptidyl copper complex. The complex exhibited good stability constants, suitable redox potentials and excellent intrinsic activity. This complex was further assayed in cells for its antioxidant properties and showed beneficial effects when cells were subjected to oxidative stress.
A strategy combining combinatorial chemistry and an activity-based screening leads to the development of a peptidyl catalytic drug that reduces the oxidative stress in cellular models. |
| doi_str_mv | 10.1039/c9cc07920c |
| format | Article |
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A strategy combining combinatorial chemistry and an activity-based screening leads to the development of a peptidyl catalytic drug that reduces the oxidative stress in cellular models.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c9cc07920c</identifier><identifier>PMID: 31820751</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Amino Acid Sequence ; Antioxidants ; Assaying ; Biocompatible Materials - chemistry ; Biocompatible Materials - metabolism ; Biocompatible Materials - pharmacology ; Chemical Sciences ; Colon - cytology ; Colon - drug effects ; Colon - metabolism ; Combinatorial analysis ; Coordination chemistry ; Coordination compounds ; Copper ; Copper - chemistry ; Copper - metabolism ; Copper compounds ; HT29 Cells ; Humans ; Interleukin-8 - metabolism ; Lipopolysaccharides - toxicity ; Oxidation ; Oxidative Stress - drug effects ; Peptides - chemistry ; Peptides - metabolism ; Stability constants ; Superoxide dismutase ; Superoxide Dismutase - metabolism</subject><ispartof>Chemical communications (Cambridge, England), 2020-01, Vol.56 (3), p.399-42</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-19955dc2f4b017fc91cf2371fdf0ce18cf4b125812e0e9f5e144165220c7b4c83</citedby><cites>FETCH-LOGICAL-c407t-19955dc2f4b017fc91cf2371fdf0ce18cf4b125812e0e9f5e144165220c7b4c83</cites><orcidid>0000-0001-5570-8311 ; 0000-0002-1300-2692 ; 0000-0003-0255-1650 ; 0000-0003-3291-3309 ; 0000-0003-3339-0239 ; 0000-0003-3596-9893 ; 0000-0002-7621-6719</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31820751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02378888$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Vincent, Amandine</creatorcontrib><creatorcontrib>Fores, Jennifer Rodon</creatorcontrib><creatorcontrib>Tauziet, Elodie</creatorcontrib><creatorcontrib>Quévrain, Elodie</creatorcontrib><creatorcontrib>Dancs, Ágnes</creatorcontrib><creatorcontrib>Conte-Daban, Amandine</creatorcontrib><creatorcontrib>Bernard, Anne-Sophie</creatorcontrib><creatorcontrib>Pelupessy, Philippe</creatorcontrib><creatorcontrib>Coulibaly, Koudedja</creatorcontrib><creatorcontrib>Seksik, Philippe</creatorcontrib><creatorcontrib>Hureau, Christelle</creatorcontrib><creatorcontrib>Selmeczi, Katalin</creatorcontrib><creatorcontrib>Policar, Clotilde</creatorcontrib><creatorcontrib>Delsuc, Nicolas</creatorcontrib><title>An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>A combinatorial approach using a one-bead-one-compound method and a screening based on a SOD-activity assay was set up for the discovery of an efficient peptidyl copper complex. The complex exhibited good stability constants, suitable redox potentials and excellent intrinsic activity. This complex was further assayed in cells for its antioxidant properties and showed beneficial effects when cells were subjected to oxidative stress.
A strategy combining combinatorial chemistry and an activity-based screening leads to the development of a peptidyl catalytic drug that reduces the oxidative stress in cellular models.</description><subject>Amino Acid Sequence</subject><subject>Antioxidants</subject><subject>Assaying</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - metabolism</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Chemical Sciences</subject><subject>Colon - cytology</subject><subject>Colon - drug effects</subject><subject>Colon - metabolism</subject><subject>Combinatorial analysis</subject><subject>Coordination chemistry</subject><subject>Coordination compounds</subject><subject>Copper</subject><subject>Copper - chemistry</subject><subject>Copper - metabolism</subject><subject>Copper compounds</subject><subject>HT29 Cells</subject><subject>Humans</subject><subject>Interleukin-8 - metabolism</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Oxidation</subject><subject>Oxidative Stress - drug effects</subject><subject>Peptides - chemistry</subject><subject>Peptides - metabolism</subject><subject>Stability constants</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkk2P1SAUQInROOPoxr2GxI2aVPlsy_KlUWeSl8xGE3cNpeBjLKUCbaa_xT8rnTe-SYYN5N7DgcsFgNcYfcKIis9KKIUqQZB6As4xLVnBWf3z6bbmoqgo42fgRYw3KA_M6-fgjOKaoIrjc_B3N0It41okX1g3DdrpMUHlXWdHmXywcoBymoKX6gDtuPhhseMvKEcoVbKLTWvRyah7KGOUKzQ-wHTQsLdR-UWHFXoDJZz0lGy_Dlk8TTps_nzULXTWWfV7E8Y5x_2t7e_2ujll6UvwzMgh6lf38wX48fXL9-ay2F9_u2p2-0IxVKUCC8F5r4hhHcKVUQIrQ2iFTW-Q0rhWOYEJrzHRSAvDNWYMl5zk96o6pmp6AT4cvQc5tFOwToa19dK2l7t9u8VQ1tV5LDiz749sfpI_s46pdblUPQxy1H6OLaGEsrKsEc3ou0fojZ_DmCvJFMVVWVK2CT8eKRV8jEGb0w0warf2to1omrv2Nhl-e6-cO6f7E_q_nxl4cwRCVKfsw_-g_wD_pavO</recordid><startdate>20200102</startdate><enddate>20200102</enddate><creator>Vincent, Amandine</creator><creator>Fores, Jennifer Rodon</creator><creator>Tauziet, Elodie</creator><creator>Quévrain, Elodie</creator><creator>Dancs, Ágnes</creator><creator>Conte-Daban, Amandine</creator><creator>Bernard, Anne-Sophie</creator><creator>Pelupessy, Philippe</creator><creator>Coulibaly, Koudedja</creator><creator>Seksik, Philippe</creator><creator>Hureau, Christelle</creator><creator>Selmeczi, Katalin</creator><creator>Policar, Clotilde</creator><creator>Delsuc, Nicolas</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-5570-8311</orcidid><orcidid>https://orcid.org/0000-0002-1300-2692</orcidid><orcidid>https://orcid.org/0000-0003-0255-1650</orcidid><orcidid>https://orcid.org/0000-0003-3291-3309</orcidid><orcidid>https://orcid.org/0000-0003-3339-0239</orcidid><orcidid>https://orcid.org/0000-0003-3596-9893</orcidid><orcidid>https://orcid.org/0000-0002-7621-6719</orcidid></search><sort><creationdate>20200102</creationdate><title>An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase</title><author>Vincent, Amandine ; 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The complex exhibited good stability constants, suitable redox potentials and excellent intrinsic activity. This complex was further assayed in cells for its antioxidant properties and showed beneficial effects when cells were subjected to oxidative stress.
A strategy combining combinatorial chemistry and an activity-based screening leads to the development of a peptidyl catalytic drug that reduces the oxidative stress in cellular models.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>31820751</pmid><doi>10.1039/c9cc07920c</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-5570-8311</orcidid><orcidid>https://orcid.org/0000-0002-1300-2692</orcidid><orcidid>https://orcid.org/0000-0003-0255-1650</orcidid><orcidid>https://orcid.org/0000-0003-3291-3309</orcidid><orcidid>https://orcid.org/0000-0003-3339-0239</orcidid><orcidid>https://orcid.org/0000-0003-3596-9893</orcidid><orcidid>https://orcid.org/0000-0002-7621-6719</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2020-01, Vol.56 (3), p.399-42 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Antioxidants Assaying Biocompatible Materials - chemistry Biocompatible Materials - metabolism Biocompatible Materials - pharmacology Chemical Sciences Colon - cytology Colon - drug effects Colon - metabolism Combinatorial analysis Coordination chemistry Coordination compounds Copper Copper - chemistry Copper - metabolism Copper compounds HT29 Cells Humans Interleukin-8 - metabolism Lipopolysaccharides - toxicity Oxidation Oxidative Stress - drug effects Peptides - chemistry Peptides - metabolism Stability constants Superoxide dismutase Superoxide Dismutase - metabolism |
| title | An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase |
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