Effects of laparoscopic splenectomy and azygoportal disconnection on liver synthesis function and cirrhosis: a 2-year prospective study
Background Laparoscopic splenectomy and azygoportal disconnection (LSD) is widely used for the treatment of esophagogastric variceal haemorrhage and hypersplenism owing to cirrhotic portal hypertension. However, whether LSD improves liver synthesis function and cirrhosis remains unclear. The aim of...
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| description | Background
Laparoscopic splenectomy and azygoportal disconnection (LSD) is widely used for the treatment of esophagogastric variceal haemorrhage and hypersplenism owing to cirrhotic portal hypertension. However, whether LSD improves liver synthesis function and cirrhosis remains unclear. The aim of this study is to investigate the effect of LSD on liver synthesis function and cirrhosis based on a prospective 2-year follow-up study.
Methods
A total of 118 patients with cirrhotic portal hypertension who underwent LSD were included in this study. We analysed clinical data including routine blood parameters, liver function, liver-synthesised proteins (antithrombin III, protein S, and protein C), liver fibrotic markers (type IV collagen (IV-C), procollagen type III (PC-III), laminin, and hyaluronidase), portal vein diameter, and portal blood flow velocity.
Results
Postoperative portal vein diameter and portal blood flow velocity all showed gradual declines during the 2-year follow-up; compared with preoperative values, these were all significantly decreased from postoperative week (POW) 1 (all
P |
| doi_str_mv | 10.1007/s00464-019-07307-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2323466689</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2729282326</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-85d5885efa11d2872b0dad182816a19129f37ca90a4f4a8b63b3f085bfebca683</originalsourceid><addsrcrecordid>eNp9kc1qFjEUhoMo9mv1BlxIwI2baH5mJkl3UmorFNzoOpyZSdop8yXTZKYw3oC37fk6tQUXQuBA3uc9P7yEvBP8k-Bcfy6cV03FuLCMa8U10y_ITlRKMimFeUl23CrOpLbVETku5ZYjb0X9mhwpYSQXtd6R3-ch-G4uNAU6wgQ5lS5NQ0fLNPqIStqvFGJP4dd6naaUZxhpPyAUD-qQIsU3Dvc-07LG-caXodCwxE07OLsh55uE36cUqGSrh0wnnDMd_Peelnnp1zfkVYCx-LeP9YT8_Hr-4-ySXX2_-Hb25Yp1StczM3VfG1P7AEL00mjZ8h56vMaIBoQV0galO7AcqlCBaRvVqsBN3QbfdtAYdUI-bn1xg7vFl9nt8Rg_jhB9WoqTSqqqaRpjEf3wD3qblhxxOye1tNIg2yAlN6rDk0r2wU152ENeneDuEJPbYnIYk3uIyWk0vX9svbR73z9Z_uaCgNqAglK89vl59n_a_gHrdqAt</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2729282326</pqid></control><display><type>article</type><title>Effects of laparoscopic splenectomy and azygoportal disconnection on liver synthesis function and cirrhosis: a 2-year prospective study</title><source>SpringerLink Journals</source><creator>Bai, Dou-Sheng ; Zhou, Bao-Huan ; Qian, Jian-Jun ; Zhang, Chi ; Jin, Sheng-Jie ; Jiang, Guo-Qing</creator><creatorcontrib>Bai, Dou-Sheng ; Zhou, Bao-Huan ; Qian, Jian-Jun ; Zhang, Chi ; Jin, Sheng-Jie ; Jiang, Guo-Qing</creatorcontrib><description>Background
Laparoscopic splenectomy and azygoportal disconnection (LSD) is widely used for the treatment of esophagogastric variceal haemorrhage and hypersplenism owing to cirrhotic portal hypertension. However, whether LSD improves liver synthesis function and cirrhosis remains unclear. The aim of this study is to investigate the effect of LSD on liver synthesis function and cirrhosis based on a prospective 2-year follow-up study.
Methods
A total of 118 patients with cirrhotic portal hypertension who underwent LSD were included in this study. We analysed clinical data including routine blood parameters, liver function, liver-synthesised proteins (antithrombin III, protein S, and protein C), liver fibrotic markers (type IV collagen (IV-C), procollagen type III (PC-III), laminin, and hyaluronidase), portal vein diameter, and portal blood flow velocity.
Results
Postoperative portal vein diameter and portal blood flow velocity all showed gradual declines during the 2-year follow-up; compared with preoperative values, these were all significantly decreased from postoperative week (POW) 1 (all
P
< 0.001). Postoperative Child–Pugh scores and total bilirubin, albumin, international normalised ratio, antithrombin III, protein S, protein C, IV-C, PC-III, laminin, and hyaluronidase levels also all showed gradual improvements during the 2-year follow-up; compared with preoperative levels, these were all significantly improved from postoperative month (POM) 6, POW 1, POM 3, POM 3, POM 3, POM 6, POM 18, POW 1, POM 3, POM 24, and POM 18, respectively (all
P
< 0.05).
Conclusion
LSD not only decreases portal hypertension and improves liver function, it also enhances liver synthesis function and reduces liver fibrosis.</description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/s00464-019-07307-7</identifier><identifier>PMID: 31820157</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abdominal Surgery ; Flow velocity ; Gastroenterology ; Gynecology ; Hepatology ; Hypertension ; Laparoscopy ; Liver ; Liver cirrhosis ; Medicine ; Medicine & Public Health ; NCT ; NCT02247414 ; Proctology ; Proteins ; Surgery</subject><ispartof>Surgical endoscopy, 2020-11, Vol.34 (11), p.5074-5082</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-85d5885efa11d2872b0dad182816a19129f37ca90a4f4a8b63b3f085bfebca683</citedby><cites>FETCH-LOGICAL-c375t-85d5885efa11d2872b0dad182816a19129f37ca90a4f4a8b63b3f085bfebca683</cites><orcidid>0000-0002-8699-6624</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00464-019-07307-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00464-019-07307-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31820157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bai, Dou-Sheng</creatorcontrib><creatorcontrib>Zhou, Bao-Huan</creatorcontrib><creatorcontrib>Qian, Jian-Jun</creatorcontrib><creatorcontrib>Zhang, Chi</creatorcontrib><creatorcontrib>Jin, Sheng-Jie</creatorcontrib><creatorcontrib>Jiang, Guo-Qing</creatorcontrib><title>Effects of laparoscopic splenectomy and azygoportal disconnection on liver synthesis function and cirrhosis: a 2-year prospective study</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><addtitle>Surg Endosc</addtitle><description>Background
Laparoscopic splenectomy and azygoportal disconnection (LSD) is widely used for the treatment of esophagogastric variceal haemorrhage and hypersplenism owing to cirrhotic portal hypertension. However, whether LSD improves liver synthesis function and cirrhosis remains unclear. The aim of this study is to investigate the effect of LSD on liver synthesis function and cirrhosis based on a prospective 2-year follow-up study.
Methods
A total of 118 patients with cirrhotic portal hypertension who underwent LSD were included in this study. We analysed clinical data including routine blood parameters, liver function, liver-synthesised proteins (antithrombin III, protein S, and protein C), liver fibrotic markers (type IV collagen (IV-C), procollagen type III (PC-III), laminin, and hyaluronidase), portal vein diameter, and portal blood flow velocity.
Results
Postoperative portal vein diameter and portal blood flow velocity all showed gradual declines during the 2-year follow-up; compared with preoperative values, these were all significantly decreased from postoperative week (POW) 1 (all
P
< 0.001). Postoperative Child–Pugh scores and total bilirubin, albumin, international normalised ratio, antithrombin III, protein S, protein C, IV-C, PC-III, laminin, and hyaluronidase levels also all showed gradual improvements during the 2-year follow-up; compared with preoperative levels, these were all significantly improved from postoperative month (POM) 6, POW 1, POM 3, POM 3, POM 3, POM 6, POM 18, POW 1, POM 3, POM 24, and POM 18, respectively (all
P
< 0.05).
Conclusion
LSD not only decreases portal hypertension and improves liver function, it also enhances liver synthesis function and reduces liver fibrosis.</description><subject>Abdominal Surgery</subject><subject>Flow velocity</subject><subject>Gastroenterology</subject><subject>Gynecology</subject><subject>Hepatology</subject><subject>Hypertension</subject><subject>Laparoscopy</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>NCT</subject><subject>NCT02247414</subject><subject>Proctology</subject><subject>Proteins</subject><subject>Surgery</subject><issn>0930-2794</issn><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kc1qFjEUhoMo9mv1BlxIwI2baH5mJkl3UmorFNzoOpyZSdop8yXTZKYw3oC37fk6tQUXQuBA3uc9P7yEvBP8k-Bcfy6cV03FuLCMa8U10y_ITlRKMimFeUl23CrOpLbVETku5ZYjb0X9mhwpYSQXtd6R3-ch-G4uNAU6wgQ5lS5NQ0fLNPqIStqvFGJP4dd6naaUZxhpPyAUD-qQIsU3Dvc-07LG-caXodCwxE07OLsh55uE36cUqGSrh0wnnDMd_Peelnnp1zfkVYCx-LeP9YT8_Hr-4-ySXX2_-Hb25Yp1StczM3VfG1P7AEL00mjZ8h56vMaIBoQV0galO7AcqlCBaRvVqsBN3QbfdtAYdUI-bn1xg7vFl9nt8Rg_jhB9WoqTSqqqaRpjEf3wD3qblhxxOye1tNIg2yAlN6rDk0r2wU152ENeneDuEJPbYnIYk3uIyWk0vX9svbR73z9Z_uaCgNqAglK89vl59n_a_gHrdqAt</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Bai, Dou-Sheng</creator><creator>Zhou, Bao-Huan</creator><creator>Qian, Jian-Jun</creator><creator>Zhang, Chi</creator><creator>Jin, Sheng-Jie</creator><creator>Jiang, Guo-Qing</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8699-6624</orcidid></search><sort><creationdate>20201101</creationdate><title>Effects of laparoscopic splenectomy and azygoportal disconnection on liver synthesis function and cirrhosis: a 2-year prospective study</title><author>Bai, Dou-Sheng ; Zhou, Bao-Huan ; Qian, Jian-Jun ; Zhang, Chi ; Jin, Sheng-Jie ; Jiang, Guo-Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-85d5885efa11d2872b0dad182816a19129f37ca90a4f4a8b63b3f085bfebca683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdominal Surgery</topic><topic>Flow velocity</topic><topic>Gastroenterology</topic><topic>Gynecology</topic><topic>Hepatology</topic><topic>Hypertension</topic><topic>Laparoscopy</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>NCT</topic><topic>NCT02247414</topic><topic>Proctology</topic><topic>Proteins</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bai, Dou-Sheng</creatorcontrib><creatorcontrib>Zhou, Bao-Huan</creatorcontrib><creatorcontrib>Qian, Jian-Jun</creatorcontrib><creatorcontrib>Zhang, Chi</creatorcontrib><creatorcontrib>Jin, Sheng-Jie</creatorcontrib><creatorcontrib>Jiang, Guo-Qing</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bai, Dou-Sheng</au><au>Zhou, Bao-Huan</au><au>Qian, Jian-Jun</au><au>Zhang, Chi</au><au>Jin, Sheng-Jie</au><au>Jiang, Guo-Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of laparoscopic splenectomy and azygoportal disconnection on liver synthesis function and cirrhosis: a 2-year prospective study</atitle><jtitle>Surgical endoscopy</jtitle><stitle>Surg Endosc</stitle><addtitle>Surg Endosc</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>34</volume><issue>11</issue><spage>5074</spage><epage>5082</epage><pages>5074-5082</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><abstract>Background
Laparoscopic splenectomy and azygoportal disconnection (LSD) is widely used for the treatment of esophagogastric variceal haemorrhage and hypersplenism owing to cirrhotic portal hypertension. However, whether LSD improves liver synthesis function and cirrhosis remains unclear. The aim of this study is to investigate the effect of LSD on liver synthesis function and cirrhosis based on a prospective 2-year follow-up study.
Methods
A total of 118 patients with cirrhotic portal hypertension who underwent LSD were included in this study. We analysed clinical data including routine blood parameters, liver function, liver-synthesised proteins (antithrombin III, protein S, and protein C), liver fibrotic markers (type IV collagen (IV-C), procollagen type III (PC-III), laminin, and hyaluronidase), portal vein diameter, and portal blood flow velocity.
Results
Postoperative portal vein diameter and portal blood flow velocity all showed gradual declines during the 2-year follow-up; compared with preoperative values, these were all significantly decreased from postoperative week (POW) 1 (all
P
< 0.001). Postoperative Child–Pugh scores and total bilirubin, albumin, international normalised ratio, antithrombin III, protein S, protein C, IV-C, PC-III, laminin, and hyaluronidase levels also all showed gradual improvements during the 2-year follow-up; compared with preoperative levels, these were all significantly improved from postoperative month (POM) 6, POW 1, POM 3, POM 3, POM 3, POM 6, POM 18, POW 1, POM 3, POM 24, and POM 18, respectively (all
P
< 0.05).
Conclusion
LSD not only decreases portal hypertension and improves liver function, it also enhances liver synthesis function and reduces liver fibrosis.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31820157</pmid><doi>10.1007/s00464-019-07307-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8699-6624</orcidid></addata></record> |
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| source | SpringerLink Journals |
| subjects | Abdominal Surgery Flow velocity Gastroenterology Gynecology Hepatology Hypertension Laparoscopy Liver Liver cirrhosis Medicine Medicine & Public Health NCT NCT02247414 Proctology Proteins Surgery |
| title | Effects of laparoscopic splenectomy and azygoportal disconnection on liver synthesis function and cirrhosis: a 2-year prospective study |
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