Hepatoprotective studies on methanolic extract of caryopses of Echinochloa colona Link
The caryopses (seeds) of Echinochloa colona Link of family Poaceae are traditionally used for the treatment of jaundice. The methanolic extract of caryopses of Echinochloa colona (ECME) was evaluated for its hepatoprotective activity in paracetamol (3g/kg per oral) and ethanol (5g/kg per oral) intox...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2019-09, Vol.32 (5), p.1949-1956 |
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| container_end_page | 1956 |
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| container_issue | 5 |
| container_start_page | 1949 |
| container_title | Pakistan journal of pharmaceutical sciences |
| container_volume | 32 |
| creator | Praneetha, Pallerla Rani, Vanapatla Swaroopa Raju, Vatsavaya Satyanarayana Reddy, Yellu Narasimha Kumar, Bobbala Ravi |
| description | The caryopses (seeds) of Echinochloa colona Link of family Poaceae are traditionally used for the treatment of jaundice. The methanolic extract of caryopses of Echinochloa colona (ECME) was evaluated for its hepatoprotective activity in paracetamol (3g/kg per oral) and ethanol (5g/kg per oral) intoxicated rats while its antihepatotoxic activity against D-galactosamine (400mg/kg body weight intra peritoneal). The activity of the extract was assessed on the basis of improvement in the altered level of various serum biochemical parameters and in the changes occurred in the histology of liver of the rats. The extract was also investigated for its antioxidant potential by employing different in vitro methods. The extract exhibited ferrous ion reducing power, 1,1 Diphenyl-1-picryl hydrazyl (DPPH), superoxide, nitric oxide and hydroxyl radical scavenging activities. The significant (p |
| format | Article |
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The methanolic extract of caryopses of Echinochloa colona (ECME) was evaluated for its hepatoprotective activity in paracetamol (3g/kg per oral) and ethanol (5g/kg per oral) intoxicated rats while its antihepatotoxic activity against D-galactosamine (400mg/kg body weight intra peritoneal). The activity of the extract was assessed on the basis of improvement in the altered level of various serum biochemical parameters and in the changes occurred in the histology of liver of the rats. The extract was also investigated for its antioxidant potential by employing different in vitro methods. The extract exhibited ferrous ion reducing power, 1,1 Diphenyl-1-picryl hydrazyl (DPPH), superoxide, nitric oxide and hydroxyl radical scavenging activities. The significant (p<0.001) hepatoprotective and antioxidant activities exhibited by the extract ECME, in different in vivo models and in vitro studies respectively may be attributed to the flavonoids and phenolic compounds present in the extract.</description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 31813857</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Acetaminophen ; Animals ; Antioxidants (Nutrients) ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Biochemistry ; Biphenyl Compounds - pharmacology ; Body weight ; Echinochloa - chemistry ; Ethanol ; Flavonoids - pharmacology ; Galactosamine - pharmacology ; Grasses ; Hydroxyl Radical - metabolism ; Jaundice ; Lipid Peroxidation - drug effects ; Liver - drug effects ; Methanol - chemistry ; Nitric Oxide - metabolism ; Phenols - pharmacology ; Picrates - pharmacology ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Protective Agents - chemistry ; Protective Agents - pharmacology ; Rats ; Seeds ; Seeds - chemistry ; Superoxides - metabolism</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2019-09, Vol.32 (5), p.1949-1956</ispartof><rights>COPYRIGHT 2019 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31813857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Praneetha, Pallerla</creatorcontrib><creatorcontrib>Rani, Vanapatla Swaroopa</creatorcontrib><creatorcontrib>Raju, Vatsavaya Satyanarayana</creatorcontrib><creatorcontrib>Reddy, Yellu Narasimha</creatorcontrib><creatorcontrib>Kumar, Bobbala Ravi</creatorcontrib><title>Hepatoprotective studies on methanolic extract of caryopses of Echinochloa colona Link</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>The caryopses (seeds) of Echinochloa colona Link of family Poaceae are traditionally used for the treatment of jaundice. The methanolic extract of caryopses of Echinochloa colona (ECME) was evaluated for its hepatoprotective activity in paracetamol (3g/kg per oral) and ethanol (5g/kg per oral) intoxicated rats while its antihepatotoxic activity against D-galactosamine (400mg/kg body weight intra peritoneal). The activity of the extract was assessed on the basis of improvement in the altered level of various serum biochemical parameters and in the changes occurred in the histology of liver of the rats. The extract was also investigated for its antioxidant potential by employing different in vitro methods. The extract exhibited ferrous ion reducing power, 1,1 Diphenyl-1-picryl hydrazyl (DPPH), superoxide, nitric oxide and hydroxyl radical scavenging activities. The significant (p<0.001) hepatoprotective and antioxidant activities exhibited by the extract ECME, in different in vivo models and in vitro studies respectively may be attributed to the flavonoids and phenolic compounds present in the extract.</description><subject>Acetaminophen</subject><subject>Animals</subject><subject>Antioxidants (Nutrients)</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Biochemistry</subject><subject>Biphenyl Compounds - pharmacology</subject><subject>Body weight</subject><subject>Echinochloa - chemistry</subject><subject>Ethanol</subject><subject>Flavonoids - pharmacology</subject><subject>Galactosamine - pharmacology</subject><subject>Grasses</subject><subject>Hydroxyl Radical - metabolism</subject><subject>Jaundice</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Methanol - chemistry</subject><subject>Nitric Oxide - metabolism</subject><subject>Phenols - pharmacology</subject><subject>Picrates - pharmacology</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Protective Agents - chemistry</subject><subject>Protective Agents - pharmacology</subject><subject>Rats</subject><subject>Seeds</subject><subject>Seeds - chemistry</subject><subject>Superoxides - metabolism</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM9LwzAUgHtQ3Jz-C5Kjl0p-tGlyHGM6YeBFxVtJk5ct2ia1SUX_-3Vs8g4PHh8ffO8imxNMSM4x-Zhl1zF-YswLKeVVNmNEECbKap69b6BXKfRDSKCT-wEU02gcRBQ86iDtlQ-t0wh-06B0QsEirYa_0McjYtFa750Pet8GhXRog1do6_zXTXZpVRvh9rwX2dvj-nW1ybcvT8-r5Tbf0RKnvNFYSyZLKy2rODQYCkuYMVgyQxpZcsqVqgSnmBvKC1oIjCtpCBioRAOELbL7k3cK-B4hprpzUUPbKg9hjDVllAosBCkm9OGE7lQLtfM2HIumMdA5HTxYN92XHLMCF7Q8uu_O7rHpwNT94Lopvf5_HjsAsRJqTQ</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Praneetha, Pallerla</creator><creator>Rani, Vanapatla Swaroopa</creator><creator>Raju, Vatsavaya Satyanarayana</creator><creator>Reddy, Yellu Narasimha</creator><creator>Kumar, Bobbala Ravi</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20190901</creationdate><title>Hepatoprotective studies on methanolic extract of caryopses of Echinochloa colona Link</title><author>Praneetha, Pallerla ; Rani, Vanapatla Swaroopa ; Raju, Vatsavaya Satyanarayana ; Reddy, Yellu Narasimha ; Kumar, Bobbala Ravi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g250t-bc0c9395f9f376eb0e4f13dd093d1b95626aa786206d2642480079d1ede78be13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acetaminophen</topic><topic>Animals</topic><topic>Antioxidants (Nutrients)</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Biochemistry</topic><topic>Biphenyl Compounds - pharmacology</topic><topic>Body weight</topic><topic>Echinochloa - chemistry</topic><topic>Ethanol</topic><topic>Flavonoids - pharmacology</topic><topic>Galactosamine - pharmacology</topic><topic>Grasses</topic><topic>Hydroxyl Radical - metabolism</topic><topic>Jaundice</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - drug effects</topic><topic>Methanol - chemistry</topic><topic>Nitric Oxide - metabolism</topic><topic>Phenols - pharmacology</topic><topic>Picrates - pharmacology</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Protective Agents - chemistry</topic><topic>Protective Agents - pharmacology</topic><topic>Rats</topic><topic>Seeds</topic><topic>Seeds - chemistry</topic><topic>Superoxides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Praneetha, Pallerla</creatorcontrib><creatorcontrib>Rani, Vanapatla Swaroopa</creatorcontrib><creatorcontrib>Raju, Vatsavaya Satyanarayana</creatorcontrib><creatorcontrib>Reddy, Yellu Narasimha</creatorcontrib><creatorcontrib>Kumar, Bobbala Ravi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Praneetha, Pallerla</au><au>Rani, Vanapatla Swaroopa</au><au>Raju, Vatsavaya Satyanarayana</au><au>Reddy, Yellu Narasimha</au><au>Kumar, Bobbala Ravi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatoprotective studies on methanolic extract of caryopses of Echinochloa colona Link</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>32</volume><issue>5</issue><spage>1949</spage><epage>1956</epage><pages>1949-1956</pages><issn>1011-601X</issn><abstract>The caryopses (seeds) of Echinochloa colona Link of family Poaceae are traditionally used for the treatment of jaundice. The methanolic extract of caryopses of Echinochloa colona (ECME) was evaluated for its hepatoprotective activity in paracetamol (3g/kg per oral) and ethanol (5g/kg per oral) intoxicated rats while its antihepatotoxic activity against D-galactosamine (400mg/kg body weight intra peritoneal). The activity of the extract was assessed on the basis of improvement in the altered level of various serum biochemical parameters and in the changes occurred in the histology of liver of the rats. The extract was also investigated for its antioxidant potential by employing different in vitro methods. The extract exhibited ferrous ion reducing power, 1,1 Diphenyl-1-picryl hydrazyl (DPPH), superoxide, nitric oxide and hydroxyl radical scavenging activities. The significant (p<0.001) hepatoprotective and antioxidant activities exhibited by the extract ECME, in different in vivo models and in vitro studies respectively may be attributed to the flavonoids and phenolic compounds present in the extract.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>31813857</pmid><tpages>8</tpages></addata></record> |
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| subjects | Acetaminophen Animals Antioxidants (Nutrients) Antioxidants - chemistry Antioxidants - pharmacology Biochemistry Biphenyl Compounds - pharmacology Body weight Echinochloa - chemistry Ethanol Flavonoids - pharmacology Galactosamine - pharmacology Grasses Hydroxyl Radical - metabolism Jaundice Lipid Peroxidation - drug effects Liver - drug effects Methanol - chemistry Nitric Oxide - metabolism Phenols - pharmacology Picrates - pharmacology Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Protective Agents - chemistry Protective Agents - pharmacology Rats Seeds Seeds - chemistry Superoxides - metabolism |
| title | Hepatoprotective studies on methanolic extract of caryopses of Echinochloa colona Link |
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