Effects of Yukmijihwang-tang, a Polyherb, on the Pharmacokinetics of Metformin
Metformin is one of the most common medicines for the treatment of type 2 diabetes, however, recent studies suggest that concomitant antihyperglycemic agents should be administered for better efficacy. Yukmijihwang-tang (YMJHT) is a nephroprotective polyherb prescribed for renal disorders or diabeti...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2019-09, Vol.32 (5), p.2025-2031 |
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| container_title | Pakistan journal of pharmaceutical sciences |
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| creator | Kang, Seok Bong Shon, Ho Sang Park, Soo Jin Lee, Young Joon Ku, Sae-Kwang Song, Chang-Hyun |
| description | Metformin is one of the most common medicines for the treatment of type 2 diabetes, however, recent studies suggest that concomitant antihyperglycemic agents should be administered for better efficacy. Yukmijihwang-tang (YMJHT) is a nephroprotective polyherb prescribed for renal disorders or diabetic mellitus in traditional Korean medicine. Therefore, the pharmacokinetics between metformin and YMJHT were examined for their coadministration. Rats were orally coadministered with metformin and YMJHT as a combination group or metformin and distilled water as the corresponding control. Then, the metformin concentration in plasma and its pharmacokinetic parameters including maximum concentration (C
) and area under the plasma concentration time curve (AUC) were analyzed. There were no interactions between metformin and YMJHT in the single coadministration at intervals within 5 min. However, pretreatments with YMJHT for 6 days increased the metformin concentration and its C
and AUC (p |
| format | Article |
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) and area under the plasma concentration time curve (AUC) were analyzed. There were no interactions between metformin and YMJHT in the single coadministration at intervals within 5 min. However, pretreatments with YMJHT for 6 days increased the metformin concentration and its C
and AUC (p<0.05). The repeated coadministration for 8 days increased the C
of metformin (p<0.05). Conversely, when the combination was coadministered at 2h -intervals, there were no interactions between metformin and YMJHT after a single dosing or repeated dosing of coadministration for 7 days. These results of the present study will help structure proper dosing regimens for the concomitant therapy of metformin and YMJHT.</description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 31813867</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Analysis ; Animals ; Area Under Curve ; Combination drug therapy ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes therapy ; Drug Therapy, Combination - adverse effects ; Drugs, Chinese Herbal - pharmacology ; Herb-Drug Interactions - physiology ; Hypoglycemic agents ; Hypoglycemic Agents - pharmacokinetics ; Hypoglycemic Agents - pharmacology ; Male ; Metformin ; Metformin - pharmacokinetics ; Metformin - pharmacology ; Plants, Medicinal - adverse effects ; Rats ; Rats, Sprague-Dawley ; Type 2 diabetes ; Water</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2019-09, Vol.32 (5), p.2025-2031</ispartof><rights>COPYRIGHT 2019 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31813867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Seok Bong</creatorcontrib><creatorcontrib>Shon, Ho Sang</creatorcontrib><creatorcontrib>Park, Soo Jin</creatorcontrib><creatorcontrib>Lee, Young Joon</creatorcontrib><creatorcontrib>Ku, Sae-Kwang</creatorcontrib><creatorcontrib>Song, Chang-Hyun</creatorcontrib><title>Effects of Yukmijihwang-tang, a Polyherb, on the Pharmacokinetics of Metformin</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Metformin is one of the most common medicines for the treatment of type 2 diabetes, however, recent studies suggest that concomitant antihyperglycemic agents should be administered for better efficacy. Yukmijihwang-tang (YMJHT) is a nephroprotective polyherb prescribed for renal disorders or diabetic mellitus in traditional Korean medicine. Therefore, the pharmacokinetics between metformin and YMJHT were examined for their coadministration. Rats were orally coadministered with metformin and YMJHT as a combination group or metformin and distilled water as the corresponding control. Then, the metformin concentration in plasma and its pharmacokinetic parameters including maximum concentration (C
) and area under the plasma concentration time curve (AUC) were analyzed. There were no interactions between metformin and YMJHT in the single coadministration at intervals within 5 min. However, pretreatments with YMJHT for 6 days increased the metformin concentration and its C
and AUC (p<0.05). The repeated coadministration for 8 days increased the C
of metformin (p<0.05). Conversely, when the combination was coadministered at 2h -intervals, there were no interactions between metformin and YMJHT after a single dosing or repeated dosing of coadministration for 7 days. These results of the present study will help structure proper dosing regimens for the concomitant therapy of metformin and YMJHT.</description><subject>Analysis</subject><subject>Animals</subject><subject>Area Under Curve</subject><subject>Combination drug therapy</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes therapy</subject><subject>Drug Therapy, Combination - adverse effects</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Herb-Drug Interactions - physiology</subject><subject>Hypoglycemic agents</subject><subject>Hypoglycemic Agents - pharmacokinetics</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Male</subject><subject>Metformin</subject><subject>Metformin - pharmacokinetics</subject><subject>Metformin - pharmacology</subject><subject>Plants, Medicinal - adverse effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Type 2 diabetes</subject><subject>Water</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOwzAURLMA0VL4BZQliwb5kTjJsqrKQyrQBUiwimznOnGb2MV2hPr3BFp0pbnSaOYs5iyaYoRxwhD-mESX3m8RYmlZlhfRhOIC04Ll0-hlpRTI4GOr4s9h1-utbr-5aZIwyjzm8cZ2hxacmMfWxKGFeNNy13Npd9pA0PKv-QxBWddrcxWdK955uD79WfR-v3pbPibr14en5WKdNCRDISEMSk5YkRacqxJzQYmglKVESCxqgWguGatrSvPRLBHjeYnzjOYCF0IowHQW3R65e2e_BvCh6rWX0HXcgB18RSghBcqzLB2jd8dowzuotFE2OC7Hq6HX0hpQevQXDNEUpYT9sm9O7EH0UFd7p3vuDtX_aPQHYP1mEg</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Kang, Seok Bong</creator><creator>Shon, Ho Sang</creator><creator>Park, Soo Jin</creator><creator>Lee, Young Joon</creator><creator>Ku, Sae-Kwang</creator><creator>Song, Chang-Hyun</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20190901</creationdate><title>Effects of Yukmijihwang-tang, a Polyherb, on the Pharmacokinetics of Metformin</title><author>Kang, Seok Bong ; Shon, Ho Sang ; Park, Soo Jin ; Lee, Young Joon ; Ku, Sae-Kwang ; Song, Chang-Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g250t-26e9a26848aaf91ab32b33642bc1bdb037c66dd337364906a7917537b18bbfe13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Area Under Curve</topic><topic>Combination drug therapy</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes therapy</topic><topic>Drug Therapy, Combination - adverse effects</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Herb-Drug Interactions - physiology</topic><topic>Hypoglycemic agents</topic><topic>Hypoglycemic Agents - pharmacokinetics</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Male</topic><topic>Metformin</topic><topic>Metformin - pharmacokinetics</topic><topic>Metformin - pharmacology</topic><topic>Plants, Medicinal - adverse effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Type 2 diabetes</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Seok Bong</creatorcontrib><creatorcontrib>Shon, Ho Sang</creatorcontrib><creatorcontrib>Park, Soo Jin</creatorcontrib><creatorcontrib>Lee, Young Joon</creatorcontrib><creatorcontrib>Ku, Sae-Kwang</creatorcontrib><creatorcontrib>Song, Chang-Hyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Seok Bong</au><au>Shon, Ho Sang</au><au>Park, Soo Jin</au><au>Lee, Young Joon</au><au>Ku, Sae-Kwang</au><au>Song, Chang-Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Yukmijihwang-tang, a Polyherb, on the Pharmacokinetics of Metformin</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>32</volume><issue>5</issue><spage>2025</spage><epage>2031</epage><pages>2025-2031</pages><issn>1011-601X</issn><abstract>Metformin is one of the most common medicines for the treatment of type 2 diabetes, however, recent studies suggest that concomitant antihyperglycemic agents should be administered for better efficacy. Yukmijihwang-tang (YMJHT) is a nephroprotective polyherb prescribed for renal disorders or diabetic mellitus in traditional Korean medicine. Therefore, the pharmacokinetics between metformin and YMJHT were examined for their coadministration. Rats were orally coadministered with metformin and YMJHT as a combination group or metformin and distilled water as the corresponding control. Then, the metformin concentration in plasma and its pharmacokinetic parameters including maximum concentration (C
) and area under the plasma concentration time curve (AUC) were analyzed. There were no interactions between metformin and YMJHT in the single coadministration at intervals within 5 min. However, pretreatments with YMJHT for 6 days increased the metformin concentration and its C
and AUC (p<0.05). The repeated coadministration for 8 days increased the C
of metformin (p<0.05). Conversely, when the combination was coadministered at 2h -intervals, there were no interactions between metformin and YMJHT after a single dosing or repeated dosing of coadministration for 7 days. These results of the present study will help structure proper dosing regimens for the concomitant therapy of metformin and YMJHT.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>31813867</pmid><tpages>7</tpages></addata></record> |
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| subjects | Analysis Animals Area Under Curve Combination drug therapy Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetes therapy Drug Therapy, Combination - adverse effects Drugs, Chinese Herbal - pharmacology Herb-Drug Interactions - physiology Hypoglycemic agents Hypoglycemic Agents - pharmacokinetics Hypoglycemic Agents - pharmacology Male Metformin Metformin - pharmacokinetics Metformin - pharmacology Plants, Medicinal - adverse effects Rats Rats, Sprague-Dawley Type 2 diabetes Water |
| title | Effects of Yukmijihwang-tang, a Polyherb, on the Pharmacokinetics of Metformin |
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