Probing Medulloblastoma Initiation at the Single-Cell Level

Probing Medulloblastoma Initiation at the Single-Cell Level

Medulloblastoma is a pediatric brain tumor arising from the developing cerebellum. Despite significant strides in classifying tumor subgroups and identifying underlying genetic mutations, progress in clinical outcomes has been notably slower. About 30% of patients experience relapse after treatment,...

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Veröffentlicht in:Trends in Cancer 2019-12, Vol.5 (12), p.759-761
Hauptverfasser: Okonechnikov, Konstantin, Pfister, Stefan M, Kutscher, Lena M
Format: Artikel
Sprache:eng
Schlagworte:
Carcinogenesis
Cerebellar Neoplasms
Child
Humans
Medulloblastoma
Recurrence
Transcriptome
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creator Okonechnikov, Konstantin
Pfister, Stefan M
Kutscher, Lena M
description Medulloblastoma is a pediatric brain tumor arising from the developing cerebellum. Despite significant strides in classifying tumor subgroups and identifying underlying genetic mutations, progress in clinical outcomes has been notably slower. About 30% of patients experience relapse after treatment, possibly because of our inability to identify and eliminate the cancer stem cells. Zhang et al. recently investigated these cells in the SHH subgroup of medulloblastoma and identified drugs that may target them.
doi_str_mv 10.1016/j.trecan.2019.10.002
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subjects Carcinogenesis
Cerebellar Neoplasms
Child
Humans
Medulloblastoma
Recurrence
Transcriptome
title Probing Medulloblastoma Initiation at the Single-Cell Level
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