Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4(3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers

[Display omitted] •Twenty-four compounds of novel quinazolin-4(3H)-one derivatives were designed and synthesized.•Cytotoxic activities were evaluated against HepG-2, MCF-7 and HCT-116 cell lines.•In vitro anti VEGFR-2 and in vivo antitumor activities were evaluated.•Molecular docking studies were ca...

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Veröffentlicht in:	Bioorganic chemistry 2020-01, Vol.94, p.103422-103422, Article 103422
Hauptverfasser:	Mahdy, Hazem A., Ibrahim, Mohammed K., Metwaly, Ahmed M., Belal, Amany, Mehany, Ahmed B.M., El-Gamal, Kamal M.A., El-Sharkawy, Abdou, Elhendawy, Mostafa A., Radwan, Mohamed M., Elsohly, Mahmoud A., Eissa, Ibrahim H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Humans In vivo studies Models, Molecular Molecular docking Molecular Structure Quinazolin-4(3H)-one Quinazolinones Structure-Activity Relationship Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors VEGFR-2
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