Urothelial Carcinoma Detection Based on Copy Number Profiles of Urinary Cell-Free DNA by Shallow Whole-Genome Sequencing

Current noninvasive assays for urothelial carcinoma (UC) lack clinical sensitivity and specificity. Given the utility of plasma cell-free DNA (cfDNA) bio-markers, the development of urinary cfDNA biomarkers may improve the diagnostic sensitivity. We assessed copy number alterations (CNAs) by shallow...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2020-01, Vol.66 (1), p.188-198
Hauptverfasser:	Ge, Guangzhe, Peng, Ding, Guan, Bao, Zhou, Yuanyuan, Gong, Yanqing, Shi, Yue, Hao, Xueyu, Xu, Zhengzheng, Qi, Jie, Lu, Huan, Zhang, Xiaoyun, Zhan, Yonghao, Li, Yifan, Wu, Yucai, Ding, Guangpu, Shen, Qi, He, Qun, Li, Xuesong, Zhou, Liqun, Ci, Weimin
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biomarkers Bladder Bladder cancer Cancer Carcinoma Classifiers (sedimentation) Copy number Deoxyribonucleic acid Diagnostic systems DNA DNA methylation DNA sequencing FDA approval Genetic aspects Genomes Genomics Kidney cancer Medical screening Mutation Nucleotide sequencing Patients Prostate Prostate cancer Sensitivity analysis Support vector machines Tumors Urine Urothelial carcinoma Whole genome sequencing
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