Epstein-Barr Virus–Associated Smooth Muscle Tumor of the Spine After Bone Marrow Transplant: Case Report and Review of Literature
Epstein-Barr virus–associated smooth muscle tumors (SMTs) are rare neoplasms that have been found to develop in immunocompromised patients. Three distinct groups of affected patients have been described: (1) human immunodeficiency virus–infected patients, (2) post-transplant patients, and (3) patien...
Gespeichert in:
| Veröffentlicht in: | World neurosurgery 2020-03, Vol.135, p.192-196 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 196 |
|---|---|
| container_issue | |
| container_start_page | 192 |
| container_title | World neurosurgery |
| container_volume | 135 |
| creator | Calafiore, Rebecca Mouchtouris, Nikolaos Flomenberg, Neal Harrop, James S. |
| description | Epstein-Barr virus–associated smooth muscle tumors (SMTs) are rare neoplasms that have been found to develop in immunocompromised patients. Three distinct groups of affected patients have been described: (1) human immunodeficiency virus–infected patients, (2) post-transplant patients, and (3) patients with congenital immunodeficiency. The tumors can develop anywhere in the body, with 17 reported cases occurring in the spinal canal, all in patients with human immunodeficiency virus infection.
We report the first case of Epstein-Barr virus–associated SMT affecting the spinal canal in a post–bone marrow transplant adult patient. Interestingly, unlike other reported cases, the patient described here had not been receiving immunosuppressive therapy in the 2 years prior to diagnosis of the tumor.
Despite the growing number of case reports, this diagnosis presents a challenge, as the pathophysiology and optimal treatment regimens are not well understood. Results of a literature review of Epstein-Barr virus–associated SMT of the spine as well as a discussion of the presentation, management, and prognosis of this condition is presented here. |
| doi_str_mv | 10.1016/j.wneu.2019.11.160 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2322751807</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1878875019330104</els_id><sourcerecordid>2322751807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-288dc825aa0113a25cfa83d6bdcc289371e93d2e67e9d3454c91982e4d23ca003</originalsourceid><addsrcrecordid>eNp9kE1uFDEQhS0EIlHIBVggL9l0x2VPd9uIzWQUfqSJkMjA1nLsasWj6XZjuzNih8QRuGFOgkcTsqQ29RbvPVV9hLwGVgOD9mJb70eca85A1QA1tOwZOQXZyUp2rXr-pBt2Qs5T2rIyAhayEy_JiQDJlFTylPy-mlJGP1aXJkb63cc5Pfz6s0wpWG8yOnozhJDv6PWc7A7pZh5CpKGn-Q7pzeRHpMs-Y6SXocjr0hH2dBPNmKadGfM7ujIJ6VecQszUjK7Ie4_7Q8Pal5zJc8RX5EVvdgnPH_cZ-fbharP6VK2_fPy8Wq4rK5o2V1xKZyVvjGEAwvDG9kYK1946a7lUogNUwnFsO1ROLJqFVaAkx4Xjwpry_Rl5e-ydYvgxY8p68MnirlyKYU6aC867pqDpipUfrTaGlCL2eop-MPGnBqYP_PVWH_jrA38NoAv_Enrz2D_fDuieIv9oF8P7owHLl4VD1Ml6HC06H9Fm7YL_X_9f_bSYcw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2322751807</pqid></control><display><type>article</type><title>Epstein-Barr Virus–Associated Smooth Muscle Tumor of the Spine After Bone Marrow Transplant: Case Report and Review of Literature</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Calafiore, Rebecca ; Mouchtouris, Nikolaos ; Flomenberg, Neal ; Harrop, James S.</creator><creatorcontrib>Calafiore, Rebecca ; Mouchtouris, Nikolaos ; Flomenberg, Neal ; Harrop, James S.</creatorcontrib><description>Epstein-Barr virus–associated smooth muscle tumors (SMTs) are rare neoplasms that have been found to develop in immunocompromised patients. Three distinct groups of affected patients have been described: (1) human immunodeficiency virus–infected patients, (2) post-transplant patients, and (3) patients with congenital immunodeficiency. The tumors can develop anywhere in the body, with 17 reported cases occurring in the spinal canal, all in patients with human immunodeficiency virus infection.
We report the first case of Epstein-Barr virus–associated SMT affecting the spinal canal in a post–bone marrow transplant adult patient. Interestingly, unlike other reported cases, the patient described here had not been receiving immunosuppressive therapy in the 2 years prior to diagnosis of the tumor.
Despite the growing number of case reports, this diagnosis presents a challenge, as the pathophysiology and optimal treatment regimens are not well understood. Results of a literature review of Epstein-Barr virus–associated SMT of the spine as well as a discussion of the presentation, management, and prognosis of this condition is presented here.</description><identifier>ISSN: 1878-8750</identifier><identifier>EISSN: 1878-8769</identifier><identifier>DOI: 10.1016/j.wneu.2019.11.160</identifier><identifier>PMID: 31809898</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bone marrow transplant ; Decompression, Surgical ; Epstein-Barr virus ; Epstein-Barr Virus Infections - immunology ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunocompromised Host ; Immunosuppressive Agents - adverse effects ; Lymphoma, Large B-Cell, Diffuse - therapy ; Male ; Middle Aged ; Optic Neuritis - drug therapy ; Smooth muscle tumor ; Smooth Muscle Tumor - diagnostic imaging ; Smooth Muscle Tumor - immunology ; Smooth Muscle Tumor - surgery ; Smooth Muscle Tumor - virology ; Spinal Fusion ; Spinal Neoplasms - diagnostic imaging ; Spinal Neoplasms - immunology ; Spinal Neoplasms - surgery ; Spinal Neoplasms - virology ; Spine ; Thoracic Vertebrae</subject><ispartof>World neurosurgery, 2020-03, Vol.135, p.192-196</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-288dc825aa0113a25cfa83d6bdcc289371e93d2e67e9d3454c91982e4d23ca003</citedby><cites>FETCH-LOGICAL-c356t-288dc825aa0113a25cfa83d6bdcc289371e93d2e67e9d3454c91982e4d23ca003</cites><orcidid>0000-0003-1567-1942 ; 0000-0001-9495-9391</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1878875019330104$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31809898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calafiore, Rebecca</creatorcontrib><creatorcontrib>Mouchtouris, Nikolaos</creatorcontrib><creatorcontrib>Flomenberg, Neal</creatorcontrib><creatorcontrib>Harrop, James S.</creatorcontrib><title>Epstein-Barr Virus–Associated Smooth Muscle Tumor of the Spine After Bone Marrow Transplant: Case Report and Review of Literature</title><title>World neurosurgery</title><addtitle>World Neurosurg</addtitle><description>Epstein-Barr virus–associated smooth muscle tumors (SMTs) are rare neoplasms that have been found to develop in immunocompromised patients. Three distinct groups of affected patients have been described: (1) human immunodeficiency virus–infected patients, (2) post-transplant patients, and (3) patients with congenital immunodeficiency. The tumors can develop anywhere in the body, with 17 reported cases occurring in the spinal canal, all in patients with human immunodeficiency virus infection.
We report the first case of Epstein-Barr virus–associated SMT affecting the spinal canal in a post–bone marrow transplant adult patient. Interestingly, unlike other reported cases, the patient described here had not been receiving immunosuppressive therapy in the 2 years prior to diagnosis of the tumor.
Despite the growing number of case reports, this diagnosis presents a challenge, as the pathophysiology and optimal treatment regimens are not well understood. Results of a literature review of Epstein-Barr virus–associated SMT of the spine as well as a discussion of the presentation, management, and prognosis of this condition is presented here.</description><subject>Bone marrow transplant</subject><subject>Decompression, Surgical</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - immunology</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Lymphoma, Large B-Cell, Diffuse - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Optic Neuritis - drug therapy</subject><subject>Smooth muscle tumor</subject><subject>Smooth Muscle Tumor - diagnostic imaging</subject><subject>Smooth Muscle Tumor - immunology</subject><subject>Smooth Muscle Tumor - surgery</subject><subject>Smooth Muscle Tumor - virology</subject><subject>Spinal Fusion</subject><subject>Spinal Neoplasms - diagnostic imaging</subject><subject>Spinal Neoplasms - immunology</subject><subject>Spinal Neoplasms - surgery</subject><subject>Spinal Neoplasms - virology</subject><subject>Spine</subject><subject>Thoracic Vertebrae</subject><issn>1878-8750</issn><issn>1878-8769</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1uFDEQhS0EIlHIBVggL9l0x2VPd9uIzWQUfqSJkMjA1nLsasWj6XZjuzNih8QRuGFOgkcTsqQ29RbvPVV9hLwGVgOD9mJb70eca85A1QA1tOwZOQXZyUp2rXr-pBt2Qs5T2rIyAhayEy_JiQDJlFTylPy-mlJGP1aXJkb63cc5Pfz6s0wpWG8yOnozhJDv6PWc7A7pZh5CpKGn-Q7pzeRHpMs-Y6SXocjr0hH2dBPNmKadGfM7ujIJ6VecQszUjK7Ie4_7Q8Pal5zJc8RX5EVvdgnPH_cZ-fbharP6VK2_fPy8Wq4rK5o2V1xKZyVvjGEAwvDG9kYK1946a7lUogNUwnFsO1ROLJqFVaAkx4Xjwpry_Rl5e-ydYvgxY8p68MnirlyKYU6aC867pqDpipUfrTaGlCL2eop-MPGnBqYP_PVWH_jrA38NoAv_Enrz2D_fDuieIv9oF8P7owHLl4VD1Ml6HC06H9Fm7YL_X_9f_bSYcw</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Calafiore, Rebecca</creator><creator>Mouchtouris, Nikolaos</creator><creator>Flomenberg, Neal</creator><creator>Harrop, James S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1567-1942</orcidid><orcidid>https://orcid.org/0000-0001-9495-9391</orcidid></search><sort><creationdate>202003</creationdate><title>Epstein-Barr Virus–Associated Smooth Muscle Tumor of the Spine After Bone Marrow Transplant: Case Report and Review of Literature</title><author>Calafiore, Rebecca ; Mouchtouris, Nikolaos ; Flomenberg, Neal ; Harrop, James S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-288dc825aa0113a25cfa83d6bdcc289371e93d2e67e9d3454c91982e4d23ca003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bone marrow transplant</topic><topic>Decompression, Surgical</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - immunology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Lymphoma, Large B-Cell, Diffuse - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Optic Neuritis - drug therapy</topic><topic>Smooth muscle tumor</topic><topic>Smooth Muscle Tumor - diagnostic imaging</topic><topic>Smooth Muscle Tumor - immunology</topic><topic>Smooth Muscle Tumor - surgery</topic><topic>Smooth Muscle Tumor - virology</topic><topic>Spinal Fusion</topic><topic>Spinal Neoplasms - diagnostic imaging</topic><topic>Spinal Neoplasms - immunology</topic><topic>Spinal Neoplasms - surgery</topic><topic>Spinal Neoplasms - virology</topic><topic>Spine</topic><topic>Thoracic Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calafiore, Rebecca</creatorcontrib><creatorcontrib>Mouchtouris, Nikolaos</creatorcontrib><creatorcontrib>Flomenberg, Neal</creatorcontrib><creatorcontrib>Harrop, James S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>World neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calafiore, Rebecca</au><au>Mouchtouris, Nikolaos</au><au>Flomenberg, Neal</au><au>Harrop, James S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epstein-Barr Virus–Associated Smooth Muscle Tumor of the Spine After Bone Marrow Transplant: Case Report and Review of Literature</atitle><jtitle>World neurosurgery</jtitle><addtitle>World Neurosurg</addtitle><date>2020-03</date><risdate>2020</risdate><volume>135</volume><spage>192</spage><epage>196</epage><pages>192-196</pages><issn>1878-8750</issn><eissn>1878-8769</eissn><abstract>Epstein-Barr virus–associated smooth muscle tumors (SMTs) are rare neoplasms that have been found to develop in immunocompromised patients. Three distinct groups of affected patients have been described: (1) human immunodeficiency virus–infected patients, (2) post-transplant patients, and (3) patients with congenital immunodeficiency. The tumors can develop anywhere in the body, with 17 reported cases occurring in the spinal canal, all in patients with human immunodeficiency virus infection.
We report the first case of Epstein-Barr virus–associated SMT affecting the spinal canal in a post–bone marrow transplant adult patient. Interestingly, unlike other reported cases, the patient described here had not been receiving immunosuppressive therapy in the 2 years prior to diagnosis of the tumor.
Despite the growing number of case reports, this diagnosis presents a challenge, as the pathophysiology and optimal treatment regimens are not well understood. Results of a literature review of Epstein-Barr virus–associated SMT of the spine as well as a discussion of the presentation, management, and prognosis of this condition is presented here.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31809898</pmid><doi>10.1016/j.wneu.2019.11.160</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-1567-1942</orcidid><orcidid>https://orcid.org/0000-0001-9495-9391</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1878-8750 |
| ispartof | World neurosurgery, 2020-03, Vol.135, p.192-196 |
| issn | 1878-8750 1878-8769 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2322751807 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Bone marrow transplant Decompression, Surgical Epstein-Barr virus Epstein-Barr Virus Infections - immunology Hematopoietic Stem Cell Transplantation Humans Immunocompromised Host Immunosuppressive Agents - adverse effects Lymphoma, Large B-Cell, Diffuse - therapy Male Middle Aged Optic Neuritis - drug therapy Smooth muscle tumor Smooth Muscle Tumor - diagnostic imaging Smooth Muscle Tumor - immunology Smooth Muscle Tumor - surgery Smooth Muscle Tumor - virology Spinal Fusion Spinal Neoplasms - diagnostic imaging Spinal Neoplasms - immunology Spinal Neoplasms - surgery Spinal Neoplasms - virology Spine Thoracic Vertebrae |
| title | Epstein-Barr Virus–Associated Smooth Muscle Tumor of the Spine After Bone Marrow Transplant: Case Report and Review of Literature |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T18%3A03%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Epstein-Barr%20Virus%E2%80%93Associated%20Smooth%20Muscle%20Tumor%20of%20the%20Spine%20After%20Bone%20Marrow%20Transplant:%20Case%20Report%20and%20Review%20of%20Literature&rft.jtitle=World%20neurosurgery&rft.au=Calafiore,%20Rebecca&rft.date=2020-03&rft.volume=135&rft.spage=192&rft.epage=196&rft.pages=192-196&rft.issn=1878-8750&rft.eissn=1878-8769&rft_id=info:doi/10.1016/j.wneu.2019.11.160&rft_dat=%3Cproquest_cross%3E2322751807%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2322751807&rft_id=info:pmid/31809898&rft_els_id=S1878875019330104&rfr_iscdi=true |