FoxO3 reverses 5-fluorouracil resistance in human colorectal cancer cells by inhibiting the Nrf2/TR1 signaling pathway

5-fluorouracil (5-FU) is widely used in chemotherapy for colorectal cancer (CRC), but a high rate of chemoresistance reduces its effectiveness in clinical treatment. We found remarkably decreased expression of forkhead box 3 (FoxO3) protein, a tumor inhibitor, in 5-FU-resistant SW620 and HCT-8 (SW62...

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Veröffentlicht in:	Cancer letters 2020-02, Vol.470, p.29-42
Hauptverfasser:	Liu, Chao, Zhao, Yan, Wang, Jianing, Yang, Yan, Zhang, Yan, Qu, Xinliang, Peng, Sishi, Yao, Zhaoying, Zhao, Shuli, He, Bangshun, Mi, Qiongyu, Zhu, Yubing, Liu, Xiuting, Zou, Jianjun, Zhang, Xu, Du, Qianming
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Cancer therapies Cell cycle Chemoresistance Chemotherapy Colorectal cancer Colorectal cancer cells Colorectal carcinoma Drug resistance Forkhead protein FoxO3 FOXO3 protein Intracellular Intracellular signalling Kinases Membranes Nrf2 NRF2 protein Plasmids Proteins Reactive oxygen species Reductase Reductases Signal transduction Thioredoxin Transcription factors
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