Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate
A glassy carbon electrode (GCE) was modified with cerium-doped ZnO nanoflowers (Ce-ZnO/GCE) to obtain a sensor for direct simultaneous detection of the cancer drugs epirubicin and methotrexate. XRD, SEM and EDX techniques were used to characterize their morphology and structure. Electrochemical impe...
Gespeichert in:
| Veröffentlicht in: | Mikrochimica acta (1966) 2020-01, Vol.187 (1), p.24-24, Article 24 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 24 |
|---|---|
| container_issue | 1 |
| container_start_page | 24 |
| container_title | Mikrochimica acta (1966) |
| container_volume | 187 |
| creator | Jandaghi, Nezhat Jahani, Shohreh Foroughi, Mohammad Mehdi Kazemipour, Maryam Ansari, Mehdi |
| description | A glassy carbon electrode (GCE) was modified with cerium-doped ZnO nanoflowers (Ce-ZnO/GCE) to obtain a sensor for direct simultaneous detection of the cancer drugs epirubicin and methotrexate. XRD, SEM and EDX techniques were used to characterize their morphology and structure. Electrochemical impedance spectroscopy was applied to characterize the electrochemical features of the modified GCE. The experimental conditions were optimized. Diffusion coefficients and heterogeneous rate constants were determined for the oxidation of epirubicin. The differential pulse voltammetric response to epirubicin has a peak near 0.7 V (vs. Ag/AgCl at a scan rate of 50 mV s
−1
) and is linear in the 0.01 to 600 μM concentration range, and the detection limit is 2.3 nM (S/
N
= 5). The differential pulse voltammetric response to methotrexate has a peak near 0.75 V (vs. Ag/AgCl and the same scan rate) and is linear in the 0.01 to 500 μM concentration range, and the detection limit is 6.3 nM (S/
N
= 5). The method was applied to the simultaneous determination of epirubicin and methotrexate in pharmaceutical injections and in spiked diluted blood specimens.
Graphical abstract
Schematic of an electrochemical sensor based on Ce-doped ZnO nano-flowers modified glassy carbon electrode for detecting epirubicin |
| doi_str_mv | 10.1007/s00604-019-4016-2 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2322743328</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A715057554</galeid><sourcerecordid>A715057554</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-ca0eec67620f2b004f813014da930199458b60bb116068b51f145df9fff59b393</originalsourceid><addsrcrecordid>eNp9kc-KFDEQxoMo7uzoA3iRgBcvWSvd6fT0cRn8s7CwF714Cel0ZSZLd9ImaXQfxPc1Ta-CIJJAUcnvK6rqI-QVhysO0L5LABIEA94xAVyy6gnZcVFL1kBbPyU7gEqyWrbVBblM6R6At7ISz8lFzQ_QdrzbkZ9HjG6Z2BBmHKgdw3eMLJ31mn31d9RrH5iJDynrcXQZE9Xl0oQ-OX-iJkxz8OgztSHS5KZlzNpjWBLFEU2OwZxxckaPdMCMcXJeZxc8DZbi7OLSO-M81X6gE-ZzyBF_6IwvyDOrx4QvH-OefPnw_vPxE7u9-3hzvL5lRrRtZkYDopFlKLBVDyDsgdfAxaC7ErpONIdeQt9zLkEe-oZbLprBdtbapuvrrt6Tt1vdOYZvC6asJpcMjuM2g6rqqmpFXVeHgr7Z0JMeUTlvS6_arLi6bnkDTds0olBX_6DKGdYtlE1ZV97_EvBNYGJIKaJVc3STjg-Kg1pNVpvJqsyjVpNLT3vy-rHrpZ9w-KP47WoBqg1I5cufMKr7sERfNvmfqr8AjyezwQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2322743328</pqid></control><display><type>article</type><title>Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Jandaghi, Nezhat ; Jahani, Shohreh ; Foroughi, Mohammad Mehdi ; Kazemipour, Maryam ; Ansari, Mehdi</creator><creatorcontrib>Jandaghi, Nezhat ; Jahani, Shohreh ; Foroughi, Mohammad Mehdi ; Kazemipour, Maryam ; Ansari, Mehdi</creatorcontrib><description>A glassy carbon electrode (GCE) was modified with cerium-doped ZnO nanoflowers (Ce-ZnO/GCE) to obtain a sensor for direct simultaneous detection of the cancer drugs epirubicin and methotrexate. XRD, SEM and EDX techniques were used to characterize their morphology and structure. Electrochemical impedance spectroscopy was applied to characterize the electrochemical features of the modified GCE. The experimental conditions were optimized. Diffusion coefficients and heterogeneous rate constants were determined for the oxidation of epirubicin. The differential pulse voltammetric response to epirubicin has a peak near 0.7 V (vs. Ag/AgCl at a scan rate of 50 mV s
−1
) and is linear in the 0.01 to 600 μM concentration range, and the detection limit is 2.3 nM (S/
N
= 5). The differential pulse voltammetric response to methotrexate has a peak near 0.75 V (vs. Ag/AgCl and the same scan rate) and is linear in the 0.01 to 500 μM concentration range, and the detection limit is 6.3 nM (S/
N
= 5). The method was applied to the simultaneous determination of epirubicin and methotrexate in pharmaceutical injections and in spiked diluted blood specimens.
Graphical abstract
Schematic of an electrochemical sensor based on Ce-doped ZnO nano-flowers modified glassy carbon electrode for detecting epirubicin</description><identifier>ISSN: 0026-3672</identifier><identifier>EISSN: 1436-5073</identifier><identifier>DOI: 10.1007/s00604-019-4016-2</identifier><identifier>PMID: 31807919</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Analytical Chemistry ; Cerium ; Cerium - chemistry ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Electric properties ; Electrochemistry - methods ; Electrodes ; Epirubicin - analysis ; Epirubicin - blood ; Epirubicin - chemistry ; Epirubicin - urine ; Humans ; Hydrogen-Ion Concentration ; Limit of Detection ; Methotrexate ; Methotrexate - analysis ; Methotrexate - blood ; Methotrexate - chemistry ; Methotrexate - urine ; Microengineering ; Nanochemistry ; Nanoparticles - chemistry ; Nanotechnology ; Original Paper ; Sensors ; Time Factors ; Zinc oxide ; Zinc Oxide - chemistry</subject><ispartof>Mikrochimica acta (1966), 2020-01, Vol.187 (1), p.24-24, Article 24</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2019</rights><rights>COPYRIGHT 2020 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-ca0eec67620f2b004f813014da930199458b60bb116068b51f145df9fff59b393</citedby><cites>FETCH-LOGICAL-c477t-ca0eec67620f2b004f813014da930199458b60bb116068b51f145df9fff59b393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00604-019-4016-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00604-019-4016-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31807919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jandaghi, Nezhat</creatorcontrib><creatorcontrib>Jahani, Shohreh</creatorcontrib><creatorcontrib>Foroughi, Mohammad Mehdi</creatorcontrib><creatorcontrib>Kazemipour, Maryam</creatorcontrib><creatorcontrib>Ansari, Mehdi</creatorcontrib><title>Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate</title><title>Mikrochimica acta (1966)</title><addtitle>Microchim Acta</addtitle><addtitle>Mikrochim Acta</addtitle><description>A glassy carbon electrode (GCE) was modified with cerium-doped ZnO nanoflowers (Ce-ZnO/GCE) to obtain a sensor for direct simultaneous detection of the cancer drugs epirubicin and methotrexate. XRD, SEM and EDX techniques were used to characterize their morphology and structure. Electrochemical impedance spectroscopy was applied to characterize the electrochemical features of the modified GCE. The experimental conditions were optimized. Diffusion coefficients and heterogeneous rate constants were determined for the oxidation of epirubicin. The differential pulse voltammetric response to epirubicin has a peak near 0.7 V (vs. Ag/AgCl at a scan rate of 50 mV s
−1
) and is linear in the 0.01 to 600 μM concentration range, and the detection limit is 2.3 nM (S/
N
= 5). The differential pulse voltammetric response to methotrexate has a peak near 0.75 V (vs. Ag/AgCl and the same scan rate) and is linear in the 0.01 to 500 μM concentration range, and the detection limit is 6.3 nM (S/
N
= 5). The method was applied to the simultaneous determination of epirubicin and methotrexate in pharmaceutical injections and in spiked diluted blood specimens.
Graphical abstract
Schematic of an electrochemical sensor based on Ce-doped ZnO nano-flowers modified glassy carbon electrode for detecting epirubicin</description><subject>Analytical Chemistry</subject><subject>Cerium</subject><subject>Cerium - chemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Electric properties</subject><subject>Electrochemistry - methods</subject><subject>Electrodes</subject><subject>Epirubicin - analysis</subject><subject>Epirubicin - blood</subject><subject>Epirubicin - chemistry</subject><subject>Epirubicin - urine</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Limit of Detection</subject><subject>Methotrexate</subject><subject>Methotrexate - analysis</subject><subject>Methotrexate - blood</subject><subject>Methotrexate - chemistry</subject><subject>Methotrexate - urine</subject><subject>Microengineering</subject><subject>Nanochemistry</subject><subject>Nanoparticles - chemistry</subject><subject>Nanotechnology</subject><subject>Original Paper</subject><subject>Sensors</subject><subject>Time Factors</subject><subject>Zinc oxide</subject><subject>Zinc Oxide - chemistry</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-KFDEQxoMo7uzoA3iRgBcvWSvd6fT0cRn8s7CwF714Cel0ZSZLd9ImaXQfxPc1Ta-CIJJAUcnvK6rqI-QVhysO0L5LABIEA94xAVyy6gnZcVFL1kBbPyU7gEqyWrbVBblM6R6At7ISz8lFzQ_QdrzbkZ9HjG6Z2BBmHKgdw3eMLJ31mn31d9RrH5iJDynrcXQZE9Xl0oQ-OX-iJkxz8OgztSHS5KZlzNpjWBLFEU2OwZxxckaPdMCMcXJeZxc8DZbi7OLSO-M81X6gE-ZzyBF_6IwvyDOrx4QvH-OefPnw_vPxE7u9-3hzvL5lRrRtZkYDopFlKLBVDyDsgdfAxaC7ErpONIdeQt9zLkEe-oZbLprBdtbapuvrrt6Tt1vdOYZvC6asJpcMjuM2g6rqqmpFXVeHgr7Z0JMeUTlvS6_arLi6bnkDTds0olBX_6DKGdYtlE1ZV97_EvBNYGJIKaJVc3STjg-Kg1pNVpvJqsyjVpNLT3vy-rHrpZ9w-KP47WoBqg1I5cufMKr7sERfNvmfqr8AjyezwQ</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Jandaghi, Nezhat</creator><creator>Jahani, Shohreh</creator><creator>Foroughi, Mohammad Mehdi</creator><creator>Kazemipour, Maryam</creator><creator>Ansari, Mehdi</creator><general>Springer Vienna</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200101</creationdate><title>Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate</title><author>Jandaghi, Nezhat ; Jahani, Shohreh ; Foroughi, Mohammad Mehdi ; Kazemipour, Maryam ; Ansari, Mehdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-ca0eec67620f2b004f813014da930199458b60bb116068b51f145df9fff59b393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analytical Chemistry</topic><topic>Cerium</topic><topic>Cerium - chemistry</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Electric properties</topic><topic>Electrochemistry - methods</topic><topic>Electrodes</topic><topic>Epirubicin - analysis</topic><topic>Epirubicin - blood</topic><topic>Epirubicin - chemistry</topic><topic>Epirubicin - urine</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Limit of Detection</topic><topic>Methotrexate</topic><topic>Methotrexate - analysis</topic><topic>Methotrexate - blood</topic><topic>Methotrexate - chemistry</topic><topic>Methotrexate - urine</topic><topic>Microengineering</topic><topic>Nanochemistry</topic><topic>Nanoparticles - chemistry</topic><topic>Nanotechnology</topic><topic>Original Paper</topic><topic>Sensors</topic><topic>Time Factors</topic><topic>Zinc oxide</topic><topic>Zinc Oxide - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jandaghi, Nezhat</creatorcontrib><creatorcontrib>Jahani, Shohreh</creatorcontrib><creatorcontrib>Foroughi, Mohammad Mehdi</creatorcontrib><creatorcontrib>Kazemipour, Maryam</creatorcontrib><creatorcontrib>Ansari, Mehdi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jandaghi, Nezhat</au><au>Jahani, Shohreh</au><au>Foroughi, Mohammad Mehdi</au><au>Kazemipour, Maryam</au><au>Ansari, Mehdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><addtitle>Mikrochim Acta</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>187</volume><issue>1</issue><spage>24</spage><epage>24</epage><pages>24-24</pages><artnum>24</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>A glassy carbon electrode (GCE) was modified with cerium-doped ZnO nanoflowers (Ce-ZnO/GCE) to obtain a sensor for direct simultaneous detection of the cancer drugs epirubicin and methotrexate. XRD, SEM and EDX techniques were used to characterize their morphology and structure. Electrochemical impedance spectroscopy was applied to characterize the electrochemical features of the modified GCE. The experimental conditions were optimized. Diffusion coefficients and heterogeneous rate constants were determined for the oxidation of epirubicin. The differential pulse voltammetric response to epirubicin has a peak near 0.7 V (vs. Ag/AgCl at a scan rate of 50 mV s
−1
) and is linear in the 0.01 to 600 μM concentration range, and the detection limit is 2.3 nM (S/
N
= 5). The differential pulse voltammetric response to methotrexate has a peak near 0.75 V (vs. Ag/AgCl and the same scan rate) and is linear in the 0.01 to 500 μM concentration range, and the detection limit is 6.3 nM (S/
N
= 5). The method was applied to the simultaneous determination of epirubicin and methotrexate in pharmaceutical injections and in spiked diluted blood specimens.
Graphical abstract
Schematic of an electrochemical sensor based on Ce-doped ZnO nano-flowers modified glassy carbon electrode for detecting epirubicin</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>31807919</pmid><doi>10.1007/s00604-019-4016-2</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0026-3672 |
| ispartof | Mikrochimica acta (1966), 2020-01, Vol.187 (1), p.24-24, Article 24 |
| issn | 0026-3672 1436-5073 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2322743328 |
| source | MEDLINE; SpringerLink (Online service) |
| subjects | Analytical Chemistry Cerium Cerium - chemistry Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Electric properties Electrochemistry - methods Electrodes Epirubicin - analysis Epirubicin - blood Epirubicin - chemistry Epirubicin - urine Humans Hydrogen-Ion Concentration Limit of Detection Methotrexate Methotrexate - analysis Methotrexate - blood Methotrexate - chemistry Methotrexate - urine Microengineering Nanochemistry Nanoparticles - chemistry Nanotechnology Original Paper Sensors Time Factors Zinc oxide Zinc Oxide - chemistry |
| title | Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T08%3A15%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cerium-doped%20flower-shaped%20ZnO%20nano-crystallites%20as%20a%20sensing%20component%20for%20simultaneous%20electrochemical%20determination%20of%20epirubicin%20and%20methotrexate&rft.jtitle=Mikrochimica%20acta%20(1966)&rft.au=Jandaghi,%20Nezhat&rft.date=2020-01-01&rft.volume=187&rft.issue=1&rft.spage=24&rft.epage=24&rft.pages=24-24&rft.artnum=24&rft.issn=0026-3672&rft.eissn=1436-5073&rft_id=info:doi/10.1007/s00604-019-4016-2&rft_dat=%3Cgale_proqu%3EA715057554%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2322743328&rft_id=info:pmid/31807919&rft_galeid=A715057554&rfr_iscdi=true |