Advances in the role and mechanism of BAG3 in dilated cardiomyopathy
The B cell lymphoma 2–associated anthanogene (BAG3) is an anti-apoptotic co-chaperone protein. Previous reports suggest that mutations in BAG3 are associated with dilated cardiomyopathy. This review aims to summarize the current understanding of the relationship between BAG3 mutations and dilated ca...
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| Veröffentlicht in: | Heart failure reviews 2021, Vol.26 (1), p.183-194 |
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| creator | Liu, Leiling Sun, Kaijun Zhang, Xiaojun Tang, Ying Xu, Danyan |
| description | The B cell lymphoma 2–associated anthanogene (BAG3) is an anti-apoptotic co-chaperone protein. Previous reports suggest that mutations in BAG3 are associated with dilated cardiomyopathy. This review aims to summarize the current understanding of the relationship between BAG3 mutations and dilated cardiomyopathy, primarily focusing on the role and protective mechanism of BAG3 in cardiomyocytes from individuals with dilated cardiomyopathy. The results of published studies show that BAG3 is critically important for reducing cardiomyocyte apoptosis, maintaining protein homeostasis, regulating mitochondrial stability, modulating myocardial contraction, and reducing cardiac arrhythmia, which suggests an indispensable protective mechanism of BAG3 in dilated cardiomyopathy. The significant role of BAG3 in protecting cardiomyocytes provides a new direction for the diagnosis and treatment of dilated cardiomyopathy. However, further research is required to explore the molecular mechanisms that regulate BAG3 expression, to identify a novel therapy for patients with dilated cardiomyopathy. |
| doi_str_mv | 10.1007/s10741-019-09899-7 |
| format | Article |
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Previous reports suggest that mutations in BAG3 are associated with dilated cardiomyopathy. This review aims to summarize the current understanding of the relationship between BAG3 mutations and dilated cardiomyopathy, primarily focusing on the role and protective mechanism of BAG3 in cardiomyocytes from individuals with dilated cardiomyopathy. The results of published studies show that BAG3 is critically important for reducing cardiomyocyte apoptosis, maintaining protein homeostasis, regulating mitochondrial stability, modulating myocardial contraction, and reducing cardiac arrhythmia, which suggests an indispensable protective mechanism of BAG3 in dilated cardiomyopathy. The significant role of BAG3 in protecting cardiomyocytes provides a new direction for the diagnosis and treatment of dilated cardiomyopathy. However, further research is required to explore the molecular mechanisms that regulate BAG3 expression, to identify a novel therapy for patients with dilated cardiomyopathy.</description><identifier>ISSN: 1382-4147</identifier><identifier>EISSN: 1573-7322</identifier><identifier>DOI: 10.1007/s10741-019-09899-7</identifier><identifier>PMID: 31808029</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; Apoptosis ; Apoptosis Regulatory Proteins - genetics ; Arrhythmia ; Bcl-2 protein ; Cardiology ; Cardiomyocytes ; Cardiomyopathy ; Cardiomyopathy, Dilated - genetics ; Contraction ; Dilated cardiomyopathy ; Homeostasis ; Humans ; Medicine ; Medicine & Public Health ; Mitochondria ; Molecular modelling ; Mutation ; Myocytes, Cardiac - metabolism</subject><ispartof>Heart failure reviews, 2021, Vol.26 (1), p.183-194</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-55c646b6395c1cc967f3593b04615e79d5be8f3045058ecf79b676d57028eca83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10741-019-09899-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10741-019-09899-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31808029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Leiling</creatorcontrib><creatorcontrib>Sun, Kaijun</creatorcontrib><creatorcontrib>Zhang, Xiaojun</creatorcontrib><creatorcontrib>Tang, Ying</creatorcontrib><creatorcontrib>Xu, Danyan</creatorcontrib><title>Advances in the role and mechanism of BAG3 in dilated cardiomyopathy</title><title>Heart failure reviews</title><addtitle>Heart Fail Rev</addtitle><addtitle>Heart Fail Rev</addtitle><description>The B cell lymphoma 2–associated anthanogene (BAG3) is an anti-apoptotic co-chaperone protein. Previous reports suggest that mutations in BAG3 are associated with dilated cardiomyopathy. This review aims to summarize the current understanding of the relationship between BAG3 mutations and dilated cardiomyopathy, primarily focusing on the role and protective mechanism of BAG3 in cardiomyocytes from individuals with dilated cardiomyopathy. The results of published studies show that BAG3 is critically important for reducing cardiomyocyte apoptosis, maintaining protein homeostasis, regulating mitochondrial stability, modulating myocardial contraction, and reducing cardiac arrhythmia, which suggests an indispensable protective mechanism of BAG3 in dilated cardiomyopathy. The significant role of BAG3 in protecting cardiomyocytes provides a new direction for the diagnosis and treatment of dilated cardiomyopathy. However, further research is required to explore the molecular mechanisms that regulate BAG3 expression, to identify a novel therapy for patients with dilated cardiomyopathy.</description><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Apoptosis</subject><subject>Apoptosis Regulatory Proteins - genetics</subject><subject>Arrhythmia</subject><subject>Bcl-2 protein</subject><subject>Cardiology</subject><subject>Cardiomyocytes</subject><subject>Cardiomyopathy</subject><subject>Cardiomyopathy, Dilated - genetics</subject><subject>Contraction</subject><subject>Dilated cardiomyopathy</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mitochondria</subject><subject>Molecular modelling</subject><subject>Mutation</subject><subject>Myocytes, Cardiac - metabolism</subject><issn>1382-4147</issn><issn>1573-7322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwBxiQJRaWwPkrjsdSoCBVYoHZchyHpspHsVOk_ntcUkBiYPJZfu4934PQOYFrAiBvAgHJSQJEJaAypRJ5gMZESJZIRulhrFlGE064HKGTEFYAwBWHYzRiJIMMqBqju2nxYVrrAq5a3C8d9l3tsGkL3Di7NG0VGtyV-HY6ZzuiqGrTuwJb44uqa7bd2vTL7Sk6Kk0d3Nn-nKDXh_uX2WOyeJ4_zaaLxDKa9okQNuVpnjIlLLFWpbJkQrEceEqEk6oQuctKBlyAyJwtpcpTmRZCAo1Xk7EJuhpy175737jQ66YK1tW1aV23CZrGtSWnLNuhl3_QVbfxbfydplwyFiMJixQdKOu7ELwr9dpXjfFbTUDvHOvBsY6O9ZdjLWPTxT56kzeu-Gn5lhoBNgAhPrVvzv_O_if2E0pOhDQ</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Liu, Leiling</creator><creator>Sun, Kaijun</creator><creator>Zhang, Xiaojun</creator><creator>Tang, Ying</creator><creator>Xu, Danyan</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>2021</creationdate><title>Advances in the role and mechanism of BAG3 in dilated cardiomyopathy</title><author>Liu, Leiling ; Sun, Kaijun ; Zhang, Xiaojun ; Tang, Ying ; Xu, Danyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-55c646b6395c1cc967f3593b04615e79d5be8f3045058ecf79b676d57028eca83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>Apoptosis</topic><topic>Apoptosis Regulatory Proteins - genetics</topic><topic>Arrhythmia</topic><topic>Bcl-2 protein</topic><topic>Cardiology</topic><topic>Cardiomyocytes</topic><topic>Cardiomyopathy</topic><topic>Cardiomyopathy, Dilated - genetics</topic><topic>Contraction</topic><topic>Dilated cardiomyopathy</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mitochondria</topic><topic>Molecular modelling</topic><topic>Mutation</topic><topic>Myocytes, Cardiac - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Leiling</creatorcontrib><creatorcontrib>Sun, Kaijun</creatorcontrib><creatorcontrib>Zhang, Xiaojun</creatorcontrib><creatorcontrib>Tang, Ying</creatorcontrib><creatorcontrib>Xu, Danyan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart failure reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Leiling</au><au>Sun, Kaijun</au><au>Zhang, Xiaojun</au><au>Tang, Ying</au><au>Xu, Danyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advances in the role and mechanism of BAG3 in dilated cardiomyopathy</atitle><jtitle>Heart failure reviews</jtitle><stitle>Heart Fail Rev</stitle><addtitle>Heart Fail Rev</addtitle><date>2021</date><risdate>2021</risdate><volume>26</volume><issue>1</issue><spage>183</spage><epage>194</epage><pages>183-194</pages><issn>1382-4147</issn><eissn>1573-7322</eissn><abstract>The B cell lymphoma 2–associated anthanogene (BAG3) is an anti-apoptotic co-chaperone protein. Previous reports suggest that mutations in BAG3 are associated with dilated cardiomyopathy. This review aims to summarize the current understanding of the relationship between BAG3 mutations and dilated cardiomyopathy, primarily focusing on the role and protective mechanism of BAG3 in cardiomyocytes from individuals with dilated cardiomyopathy. The results of published studies show that BAG3 is critically important for reducing cardiomyocyte apoptosis, maintaining protein homeostasis, regulating mitochondrial stability, modulating myocardial contraction, and reducing cardiac arrhythmia, which suggests an indispensable protective mechanism of BAG3 in dilated cardiomyopathy. The significant role of BAG3 in protecting cardiomyocytes provides a new direction for the diagnosis and treatment of dilated cardiomyopathy. However, further research is required to explore the molecular mechanisms that regulate BAG3 expression, to identify a novel therapy for patients with dilated cardiomyopathy.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31808029</pmid><doi>10.1007/s10741-019-09899-7</doi><tpages>12</tpages></addata></record> |
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| subjects | Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Apoptosis Apoptosis Regulatory Proteins - genetics Arrhythmia Bcl-2 protein Cardiology Cardiomyocytes Cardiomyopathy Cardiomyopathy, Dilated - genetics Contraction Dilated cardiomyopathy Homeostasis Humans Medicine Medicine & Public Health Mitochondria Molecular modelling Mutation Myocytes, Cardiac - metabolism |
| title | Advances in the role and mechanism of BAG3 in dilated cardiomyopathy |
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