Roux-en-Y Gastric Bypass as a Treatment for Barrett’s Esophagus after Sleeve Gastrectomy
Background Laparoscopic sleeve gastrectomy (SG) is the most frequently performed bariatric procedure today. While an increasing number of long-term studies report the occurrence of Barrett’s esophagus (BE) after SG, its treatment has not been studied, yet. Objectives The aim of this study was to eva...
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| Veröffentlicht in: | Obesity surgery 2020-04, Vol.30 (4), p.1273-1279 |
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| creator | Felsenreich, Daniel M. Langer, Felix B. Bichler, Christoph Eilenberg, Magdalena Jedamzik, Julia Kristo, Ivan Vock, Natalie Gensthaler, Lisa Rabl, Charlotte Todoroff, Alexander Prager, Gerhard |
| description | Background
Laparoscopic sleeve gastrectomy (SG) is the most frequently performed bariatric procedure today. While an increasing number of long-term studies report the occurrence of Barrett’s esophagus (BE) after SG, its treatment has not been studied, yet.
Objectives
The aim of this study was to evaluate Roux-en-Y gastric bypass (RYGB) as treatment for BE and reflux after SG.
Setting
University hospital setting, Austria
Methods
This multi-center study includes all patients (
n
= 10) that were converted to RYGB due to BE after SG in Austria. The mean interval between SG and RYGB was 42.7 months. The follow-up after RYGB in this study was 33.4 months. Gastroscopy, 24 h pH-metry, and manometry were performed and patients were asked to complete the BAROS and GIQLI questionnaires.
Results
Weight and BMI at the time of SG was 120.8 kg and 45.1 kg/m
2
. Eight patients (80.0%) went into remission of BE after the conversion to RYGB. Two patients had RYGB combined with hiatoplasty. The mean acid exposure time in 24 h decreased from 36.8 to 3.8% and the mean DeMeester score from 110.0 to 16.3. Patients scored 5.1 on average in the BAROS after conversion from SG to RYGB which denotes a very good outcome.
Conclusions
RYGB is an effective therapy for patients with BE and reflux after SG. Its outcomes in the current study were BE remission in the majority of cases as well as a decrease in reflux activity. Further studies with larger cohorts are necessary to confirm these findings. |
| doi_str_mv | 10.1007/s11695-019-04292-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2322739175</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2322739175</sourcerecordid><originalsourceid>FETCH-LOGICAL-c485t-44800fa328db68c1355f26300ee36b68e6d06011bc1c5671caabd8ccb2ce6dd23</originalsourceid><addsrcrecordid>eNp9kMFO3DAQhq2qqGyBF-ihitQLF5cZO7GdY0FAKyFVovQAF8txJnTRJtnaDmJvvEZfjyfBNLSVekCyZHnmm3-sj7F3CB8RQB9ERFVXHLDmUIpacP2KLVCDeXqa12wBtQJuaiG32dsYbwAEKiHesG2JBgxivWBX5-N0x2ngl8WpiyksfXG4WbsYC5dPcRHIpZ6GVHRjKA5dCJTSw_2vWBzHcf3DXU-Z6hKF4tuK6JbmEPJp7De7bKtzq0h7z_cO-35yfHH0mZ99Pf1y9OmM-9JUiZelAeicFKZtlPEoq6oTSgIQSZUrpFpQgNh49JXS6J1rWuN9I3xutULusP05dx3GnxPFZPtl9LRauYHGKVohhdCyRl1l9MN_6M04hSH_LlO6zquNLjMlZsqHMcZAnV2HZe_CxiLYJ_N2Nm-zefvbvNV56P1z9NT01P4d-aM6A3IGYm4N1xT-7X4h9hER_o6d</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2379355874</pqid></control><display><type>article</type><title>Roux-en-Y Gastric Bypass as a Treatment for Barrett’s Esophagus after Sleeve Gastrectomy</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Felsenreich, Daniel M. ; Langer, Felix B. ; Bichler, Christoph ; Eilenberg, Magdalena ; Jedamzik, Julia ; Kristo, Ivan ; Vock, Natalie ; Gensthaler, Lisa ; Rabl, Charlotte ; Todoroff, Alexander ; Prager, Gerhard</creator><creatorcontrib>Felsenreich, Daniel M. ; Langer, Felix B. ; Bichler, Christoph ; Eilenberg, Magdalena ; Jedamzik, Julia ; Kristo, Ivan ; Vock, Natalie ; Gensthaler, Lisa ; Rabl, Charlotte ; Todoroff, Alexander ; Prager, Gerhard</creatorcontrib><description>Background
Laparoscopic sleeve gastrectomy (SG) is the most frequently performed bariatric procedure today. While an increasing number of long-term studies report the occurrence of Barrett’s esophagus (BE) after SG, its treatment has not been studied, yet.
Objectives
The aim of this study was to evaluate Roux-en-Y gastric bypass (RYGB) as treatment for BE and reflux after SG.
Setting
University hospital setting, Austria
Methods
This multi-center study includes all patients (
n
= 10) that were converted to RYGB due to BE after SG in Austria. The mean interval between SG and RYGB was 42.7 months. The follow-up after RYGB in this study was 33.4 months. Gastroscopy, 24 h pH-metry, and manometry were performed and patients were asked to complete the BAROS and GIQLI questionnaires.
Results
Weight and BMI at the time of SG was 120.8 kg and 45.1 kg/m
2
. Eight patients (80.0%) went into remission of BE after the conversion to RYGB. Two patients had RYGB combined with hiatoplasty. The mean acid exposure time in 24 h decreased from 36.8 to 3.8% and the mean DeMeester score from 110.0 to 16.3. Patients scored 5.1 on average in the BAROS after conversion from SG to RYGB which denotes a very good outcome.
Conclusions
RYGB is an effective therapy for patients with BE and reflux after SG. Its outcomes in the current study were BE remission in the majority of cases as well as a decrease in reflux activity. Further studies with larger cohorts are necessary to confirm these findings.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-019-04292-7</identifier><identifier>PMID: 31808119</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Austria ; Barrett Esophagus - etiology ; Barrett Esophagus - surgery ; Esophagus ; Gastrectomy ; Gastric Bypass - adverse effects ; Gastrointestinal surgery ; Humans ; Medicine ; Medicine & Public Health ; Obesity, Morbid - surgery ; Original Contributions ; Reoperation ; Retrospective Studies ; Surgery ; Treatment Outcome ; Weight Loss</subject><ispartof>Obesity surgery, 2020-04, Vol.30 (4), p.1273-1279</ispartof><rights>The Author(s) 2020</rights><rights>Obesity Surgery is a copyright of Springer, (2020). All Rights Reserved. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-44800fa328db68c1355f26300ee36b68e6d06011bc1c5671caabd8ccb2ce6dd23</citedby><cites>FETCH-LOGICAL-c485t-44800fa328db68c1355f26300ee36b68e6d06011bc1c5671caabd8ccb2ce6dd23</cites><orcidid>0000-0003-0257-4844</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-019-04292-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-019-04292-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31808119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Felsenreich, Daniel M.</creatorcontrib><creatorcontrib>Langer, Felix B.</creatorcontrib><creatorcontrib>Bichler, Christoph</creatorcontrib><creatorcontrib>Eilenberg, Magdalena</creatorcontrib><creatorcontrib>Jedamzik, Julia</creatorcontrib><creatorcontrib>Kristo, Ivan</creatorcontrib><creatorcontrib>Vock, Natalie</creatorcontrib><creatorcontrib>Gensthaler, Lisa</creatorcontrib><creatorcontrib>Rabl, Charlotte</creatorcontrib><creatorcontrib>Todoroff, Alexander</creatorcontrib><creatorcontrib>Prager, Gerhard</creatorcontrib><title>Roux-en-Y Gastric Bypass as a Treatment for Barrett’s Esophagus after Sleeve Gastrectomy</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
Laparoscopic sleeve gastrectomy (SG) is the most frequently performed bariatric procedure today. While an increasing number of long-term studies report the occurrence of Barrett’s esophagus (BE) after SG, its treatment has not been studied, yet.
Objectives
The aim of this study was to evaluate Roux-en-Y gastric bypass (RYGB) as treatment for BE and reflux after SG.
Setting
University hospital setting, Austria
Methods
This multi-center study includes all patients (
n
= 10) that were converted to RYGB due to BE after SG in Austria. The mean interval between SG and RYGB was 42.7 months. The follow-up after RYGB in this study was 33.4 months. Gastroscopy, 24 h pH-metry, and manometry were performed and patients were asked to complete the BAROS and GIQLI questionnaires.
Results
Weight and BMI at the time of SG was 120.8 kg and 45.1 kg/m
2
. Eight patients (80.0%) went into remission of BE after the conversion to RYGB. Two patients had RYGB combined with hiatoplasty. The mean acid exposure time in 24 h decreased from 36.8 to 3.8% and the mean DeMeester score from 110.0 to 16.3. Patients scored 5.1 on average in the BAROS after conversion from SG to RYGB which denotes a very good outcome.
Conclusions
RYGB is an effective therapy for patients with BE and reflux after SG. Its outcomes in the current study were BE remission in the majority of cases as well as a decrease in reflux activity. Further studies with larger cohorts are necessary to confirm these findings.</description><subject>Austria</subject><subject>Barrett Esophagus - etiology</subject><subject>Barrett Esophagus - surgery</subject><subject>Esophagus</subject><subject>Gastrectomy</subject><subject>Gastric Bypass - adverse effects</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Contributions</subject><subject>Reoperation</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Weight Loss</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kMFO3DAQhq2qqGyBF-ihitQLF5cZO7GdY0FAKyFVovQAF8txJnTRJtnaDmJvvEZfjyfBNLSVekCyZHnmm3-sj7F3CB8RQB9ERFVXHLDmUIpacP2KLVCDeXqa12wBtQJuaiG32dsYbwAEKiHesG2JBgxivWBX5-N0x2ngl8WpiyksfXG4WbsYC5dPcRHIpZ6GVHRjKA5dCJTSw_2vWBzHcf3DXU-Z6hKF4tuK6JbmEPJp7De7bKtzq0h7z_cO-35yfHH0mZ99Pf1y9OmM-9JUiZelAeicFKZtlPEoq6oTSgIQSZUrpFpQgNh49JXS6J1rWuN9I3xutULusP05dx3GnxPFZPtl9LRauYHGKVohhdCyRl1l9MN_6M04hSH_LlO6zquNLjMlZsqHMcZAnV2HZe_CxiLYJ_N2Nm-zefvbvNV56P1z9NT01P4d-aM6A3IGYm4N1xT-7X4h9hER_o6d</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Felsenreich, Daniel M.</creator><creator>Langer, Felix B.</creator><creator>Bichler, Christoph</creator><creator>Eilenberg, Magdalena</creator><creator>Jedamzik, Julia</creator><creator>Kristo, Ivan</creator><creator>Vock, Natalie</creator><creator>Gensthaler, Lisa</creator><creator>Rabl, Charlotte</creator><creator>Todoroff, Alexander</creator><creator>Prager, Gerhard</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0257-4844</orcidid></search><sort><creationdate>20200401</creationdate><title>Roux-en-Y Gastric Bypass as a Treatment for Barrett’s Esophagus after Sleeve Gastrectomy</title><author>Felsenreich, Daniel M. ; Langer, Felix B. ; Bichler, Christoph ; Eilenberg, Magdalena ; Jedamzik, Julia ; Kristo, Ivan ; Vock, Natalie ; Gensthaler, Lisa ; Rabl, Charlotte ; Todoroff, Alexander ; Prager, Gerhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-44800fa328db68c1355f26300ee36b68e6d06011bc1c5671caabd8ccb2ce6dd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Austria</topic><topic>Barrett Esophagus - etiology</topic><topic>Barrett Esophagus - surgery</topic><topic>Esophagus</topic><topic>Gastrectomy</topic><topic>Gastric Bypass - adverse effects</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Contributions</topic><topic>Reoperation</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Felsenreich, Daniel M.</creatorcontrib><creatorcontrib>Langer, Felix B.</creatorcontrib><creatorcontrib>Bichler, Christoph</creatorcontrib><creatorcontrib>Eilenberg, Magdalena</creatorcontrib><creatorcontrib>Jedamzik, Julia</creatorcontrib><creatorcontrib>Kristo, Ivan</creatorcontrib><creatorcontrib>Vock, Natalie</creatorcontrib><creatorcontrib>Gensthaler, Lisa</creatorcontrib><creatorcontrib>Rabl, Charlotte</creatorcontrib><creatorcontrib>Todoroff, Alexander</creatorcontrib><creatorcontrib>Prager, Gerhard</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Felsenreich, Daniel M.</au><au>Langer, Felix B.</au><au>Bichler, Christoph</au><au>Eilenberg, Magdalena</au><au>Jedamzik, Julia</au><au>Kristo, Ivan</au><au>Vock, Natalie</au><au>Gensthaler, Lisa</au><au>Rabl, Charlotte</au><au>Todoroff, Alexander</au><au>Prager, Gerhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Roux-en-Y Gastric Bypass as a Treatment for Barrett’s Esophagus after Sleeve Gastrectomy</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>30</volume><issue>4</issue><spage>1273</spage><epage>1279</epage><pages>1273-1279</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
Laparoscopic sleeve gastrectomy (SG) is the most frequently performed bariatric procedure today. While an increasing number of long-term studies report the occurrence of Barrett’s esophagus (BE) after SG, its treatment has not been studied, yet.
Objectives
The aim of this study was to evaluate Roux-en-Y gastric bypass (RYGB) as treatment for BE and reflux after SG.
Setting
University hospital setting, Austria
Methods
This multi-center study includes all patients (
n
= 10) that were converted to RYGB due to BE after SG in Austria. The mean interval between SG and RYGB was 42.7 months. The follow-up after RYGB in this study was 33.4 months. Gastroscopy, 24 h pH-metry, and manometry were performed and patients were asked to complete the BAROS and GIQLI questionnaires.
Results
Weight and BMI at the time of SG was 120.8 kg and 45.1 kg/m
2
. Eight patients (80.0%) went into remission of BE after the conversion to RYGB. Two patients had RYGB combined with hiatoplasty. The mean acid exposure time in 24 h decreased from 36.8 to 3.8% and the mean DeMeester score from 110.0 to 16.3. Patients scored 5.1 on average in the BAROS after conversion from SG to RYGB which denotes a very good outcome.
Conclusions
RYGB is an effective therapy for patients with BE and reflux after SG. Its outcomes in the current study were BE remission in the majority of cases as well as a decrease in reflux activity. Further studies with larger cohorts are necessary to confirm these findings.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31808119</pmid><doi>10.1007/s11695-019-04292-7</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0257-4844</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity surgery, 2020-04, Vol.30 (4), p.1273-1279 |
| issn | 0960-8923 1708-0428 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Austria Barrett Esophagus - etiology Barrett Esophagus - surgery Esophagus Gastrectomy Gastric Bypass - adverse effects Gastrointestinal surgery Humans Medicine Medicine & Public Health Obesity, Morbid - surgery Original Contributions Reoperation Retrospective Studies Surgery Treatment Outcome Weight Loss |
| title | Roux-en-Y Gastric Bypass as a Treatment for Barrett’s Esophagus after Sleeve Gastrectomy |
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