Ruthenium-catalyzed meta-C-H bond alkylation of aryl 2-pyridyl ketones

The first example of meta-selective CAr-H bond functionalization of aryl 2-pyridyl ketones has been developed using [Ru(p-cymene)Cl2]2 as the catalyst and alkyl bromide as the coupling reagent. This development provides an efficient strategy for modifying the meta-position of aryl 2-pyridyl ketone s...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2020-01, Vol.56 (2), p.293-296
Hauptverfasser:	Li, Gang, Jia, Chunqi, Cai, Xiaofeng, Zhong, Lei, Zou, Lei, Cui, Xiuling
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Aromatic compounds Coupling (molecular) Hydrogen bonds Ketones Reagents Ruthenium
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description	The first example of meta-selective CAr-H bond functionalization of aryl 2-pyridyl ketones has been developed using [Ru(p-cymene)Cl2]2 as the catalyst and alkyl bromide as the coupling reagent. This development provides an efficient strategy for modifying the meta-position of aryl 2-pyridyl ketone skeletons, which are found in various functional molecules.
doi_str_mv	10.1039/c9cc08624b
format	Article
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source	Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects	Alkylation Aromatic compounds Coupling (molecular) Hydrogen bonds Ketones Reagents Ruthenium
title	Ruthenium-catalyzed meta-C-H bond alkylation of aryl 2-pyridyl ketones
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