Obesity and leptin influence vitamin D metabolism and action in human marrow stromal cells

•MSCs from obese women had elevated expression of CYP27A1 and vitamin D receptor.•Leptin stimulated osteoblastogenesis of and vitamin d-related genes in hMSCs.•There are links between obesity and vitamin D metabolism in human MSCs.•There are links between obesity and osteoblastogenesis in human MSCs...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2020-04, Vol.198, p.105564-105564, Article 105564
Hauptverfasser:	Li, Jing, Gao, Yuan, Yu, Tao, Lange, Jeffrey K., LeBoff, Meryl S., Gorska, Anna, Luu, Simon, Zhou, Shuanhu, Glowacki, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D Body fat Body mass index Bone marrow Bone mineral density Bone surgery Cell differentiation Human MSCs Hydroxylase Leptin Metabolism Metabolites Obesity Osteoblastogenesis Osteoblasts Stromal cells Vitamin D Vitamin D receptors Vitamin D3
Online-Zugang:	Volltext
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